Characteristics of body lotion from chitosan and alginate (Sargassum sp.) nanoparticles

Karakteristik produk body lotion dari nanopartikel kitosan dan alginat (Sargassum sp.)

Authors

DOI:

https://doi.org/10.17844/em1wpf70

Keywords:

antioxidant activity, degree of deacetylation, nanoparticle formula, viscosity, zeta potential

Abstract

Chitosan and alginate have great potential in the cosmetics industry; therefore, both were processed into chitosan alginate nanoparticles and added to body lotion formulas to increase their effectiveness. This study aimed to investigate the effect of chitosan alginate nanoparticles on the characteristics and antioxidant activity of body lotions. Body lotion formulas with additional concentrations of 0, 1, 2, and 3 g of chitosan alginate nanoparticles. This study used a completely randomized design (CRD) with chitosan alginate nanoparticle concentrations of 0, 1, 2, and 3 g. The body lotion appeared homogeneous, with no clumped particles. The characteristics of body lotion with the addition of chitosan-alginate nanoparticles are viscosity of 4596.73-6931.77 cps, spreadability of 52.4-68.9 cm, and pH value of 6.00-6.98 which are in accordance with body lotion standards. The antioxidant activity was 19.82-21.59 µM Fe². The addition of chitosan-alginate nanoparticles with particle sizes of 100-500 nm to body lotion increased the antioxidant activity.

References

Abdullah, A., Nurjanah, N., & Irma Suryani Nasution, A. (2021). Karakteristik fraksi aktif biopigmen fukosantin rumput laut cokelat sebagai antioksidan dan uv-protector. Jurnal Pengolahan Hasil Perikanan Indonesia, 24(1), 131–147. https://doi.org/10.17844/jphpi.v24i1.35411

Adhikari, H. S., & Yadav, P. N. (2018). Anticancer activity of chitosan, chitosan derivatives, and their mechanism of action. International Journal of Biomaterials, Hindawi, 1, 1–29. https://doi.org/10. 1155/2018/2952085

Akhtar, F., Rizvi, M. M. A., & Kar, S. K. (2012). Oral delivery of curcumin bound to chitosan nanoparticles cured Plasmodium yoelii infected mice. Biotechnology Advances, 30(1), 310–320. https://doi.org/10.1016/j.biotechadv.2011.05.009

Al-Momani, R. M., Arabeyyat, Z. H., Malkawi, E. E., & Al-Zibdah, M. K. (2022). Formulation and evaluation of herbal antioxidant face cream using extract of the marine seaweed Sargassum spp. (Phaeophyceae). Journal of Research in Pharmacy, 26(4), 828–833. https://doi.org/10.29228/jrp. 180

Al-Rooqi, M. M., Hassan, M. M., Moussa, Z., Obaid, R. J., Suman, N. H., Wagner, M. H., Natto, S. S. A., & Ahmed, S. A. (2022). Advancement of chitin and chitosan as promising biomaterials. Journal of Saudi Chemical Society, 26(6), 1-12. https://doi.org/10.1016/j.jscs.2022.101561

Alshawwa, S. Z., Kassem, A. A., Farid, R. M., Mostafa, S. K., & Labib, G. S. (2022). Nanocarrier drug delivery systems: characterization, limitations, future perspectives and implementation of artificial intelligence. Pharmaceutics, 14(4), 1-26. https://doi.org/10.3390/pharmaceutics14040883

Altammar, K. A. (2023). A review on nanoparticles: characteristics, synthesis, applications, and challenges. Frontiers in Microbiology, 14(4), 1–20. https://doi.org/10.3389/fmicb.2023.1155622

Alves, D. C. da S., Healy, B., Pinto, L. A. de A., Cadaval, T. R. S., & Breslin, C. B. (2021). Recent developments in chitosan-based adsorbents for the removal of pollutants from aqueous environments. Molecules, 26(3), 1-45. https://doi.org/10.3390/molecules26030594

Andriamanantoanina, H., & Rinaudo, M. (2010). Characterization of the alginates from five madagascan brown algae. Carbohydrate Polymers, 82(3), 555–560. https://doi.org/10.1016/j.carbpol.2010.05. 002

Ayoka, T. O., Ezema, B. O., Eze, C. N., & Nnadi, C. O. (2022). Antioxidants for the prevention and treatment of non-communicable diseases. Journal of Exploratory Research in Pharmacology, 7(3), 179–189. https://doi.org/10.14218/jerp.2022.00028

Badawy, M. E. I., & Rabea, E. I. (2016). Synthesis and antimicrobial activity of n -(6-carboxyl cyclohex-3-ene carbonyl) chitosan with different degrees of substitution. International Journal of Carbohydrate Chemistry, 2016(1), 1–10. https://doi.org/10.1155/2016/6046232

Basmal, J., Prasetyo, A., & Farida, Y. (2007). Pengaruh suhu eterifikasi terhadap kualitas dan kuantitas kitosan larut air yang dibuat dari cangkang rajungan. Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan, 2(2). https://doi.org/10.15578/jpbkp.v2i2. 453

Benzie, I. F. F., & Szeto, Y. T. (1999). Total antioxidant capacity of teas by the ferric reducing/antioxidant power assay. Journal of Agricultural and Food Chemistry, 47(2), 633–636. https://doi.org/10.1021/jf9807768

Bhattacharjee, S. (2016). DLS and zeta potential - what they are and what they are not? Journal of Controlled Release, 235, 337–351. https://doi.org/10.1016/j.jconrel.2016.06.017

Bilal, M., & Iqbal, H. M. N. (2020). New insights on unique features and role of nanostructured materials in cosmetics. Cosmetics, 7(2), 1–16. https://doi.org/10.3390/cosmetics7020024

Czechowska-Biskup, R., Jarosińska, D., Rokita, B., Ulański, P., & Rosiak, J. M. (2012). Determination of degree of deacetylation of chitosan - Comparision of methods. Progress on Chemistry and Application of Chitin and Its Derivatives, 17, 5–20.

[BSN] Badan Standardisasi Nasional. (1996). SNI 16-4399-1996: Sediaan Tabir Surya. Badan Standardisasi Nasional.

[BSN] Badan Standardisasi Nasional. (2010). SNI 2354.1:2010: Cara uji kimia - Bagian 1 : Penentuan kadar abu dan abu tak larut dalam asam pada produk perikanan. Badan Standardisasi Nasional.

[BSN] Badan Standardisasi Nasional. (2013). SNI 7949:2013: Kitosan - Syarat mutu dan pengolahan. Badan Standardisasi Nasional.

[BSN] Badan Standardisasi Nasional. (2015a). SNI 2354.2:2015: Cara uji kimia – Bagian 2: Pengujian kadar air pada produk perikanan. Badan Standardisasi Nasional.

[BSN] Badan Standardisasi Nasional. (2015b). SNI 2346:2015: Pedoman pengujian sensori pada produk perikanan. Badan Standardisasi Nasional.

[BSN] Badan Standardisasi Nasional. (2019). SNI 6989.11-2019: Air dan Air Limbah – Bagian 11: Cara uji derajat keasaman (pH) dengan menggunakan alat pH meter. Badan Standardisasi Nasional.

Cakasana, N., Suprijanto, J., & Sabdono, A. (2014). Aktivitas antioksidan kitosan yang diproduksi dari cangkang kerang simping (Amusium sp.). Journal of Marine Research, 3(4), 395–404. http://ejournal-s1.undip.ac.id/index.php/jmr

Canama, G. J. C., Delco, M. C. L., Talandron, R. A., & Tan, N. P. (2023). Synthesis of chitosan-silver nanocomposite and its evaluation as an antibacterial coating for mobile phone glass protectors. American Chemical Society Omega, 8(20), 17699–17711. https://doi.org/10.1021/acsomega.3c00191

Carrouel, F., Viennot, S., Ottolenghi, L., Gaillard, C., & Bourgeois, D. (2020). Nanoparticles as anti-microbial, anti-inflammatory, and remineralizing agents in oral care cosmetics: A review of the current situation. Nanomaterials, 10(1) 1-32. https://doi.org/10.3390/nano10010140

Crini, G. (2019). Historical review on chitin and chitosan biopolymers. Environmental Chemistry Letters, 17(4), 1623–1643. https://doi.org/10.1007/s10311-019-00901-0

D’Orazio, J., Jarrett, S., Amaro-Ortiz, A., & Scott, T. (2013). UV radiation and the skin. International Journal of Molecular Sciences, 14(6), 12222–12248. https://doi.org/10.3390/ijms140612222

Damayanti, H., Wikarsa, S., & Jafar, G. (2019). Formulasi nanoemulgel ekstrak kulit manggis (Garcinia mangostana L .). Jurnal Riset Kefarmasian Indonesia, 1(3), 166-176. https://doi.org/10.33759/jrki.v1i3..53

Danaei, M., Dehghankhold, M., Ataei, S., Hasanzadeh Davarani, F., Javanmard, R., Dokhani, A., Khorasani, S., & Mozafari, M. R. (2018). Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems. Pharmaceutics, 10(2), 1–17. https://doi.org/10.3390/pharmaceutics10020057

Diharningrum, I. M., & Husni, A. (2018). Metode ekstraksi jalur asam dan kalsium alginat berpengaruh pada mutu alginat rumput laut cokelat Sargassum hystrix J. Agardh. Jurnal Pengolahan Hasil Perikanan Indonesia, 21(3), 532–542. https://doi.org/10.17844/jphpi.v21i3.24737

Dominica, D., & Handayani, D. (2019). Formulasi dan evaluasi sediaan lotion dari ekstrak daun lengkeng (Dimocarpus longan) sebagai antioksidan. Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 6(1), 6–11.

Erungan, A. C., Purwaningsih, S., & Anita, S. B. (2019). Aplikasi karaginan dalam pembuatan skin lotion - application of carrageenan in making of skin lotion. Jurnal Pengolahan Hasil Perikanan Indonesia, 12(2), 128–143. https://doi.org/10.17844/jphpi.v12i2.873

Fatullayeva, S., Tagiyev, D., Zeynalov, N., Mammadova, S., & Aliyeva, E. (2022). Recent advances of chitosan-based polymers in biomedical applications and environmental protection. Journal of Polymer Research, 29(259), 1-19. https://doi.org/10.1007/s10965-022-03121-3

Fransiska, D., Darmawan, M., Sinurat, E., Sedayu, B. B., Wardhana, Y. W., Herdiana, Y., & Setiana, G. P. (2021). Characteristics of oil in water (o/w) type lotions incorporated with kappa/iota carrageenan. IOP Conference Series: Earth and Environmental Science, 715(1). https://doi.org /10.1088/1755-1315/715/1/012050

Fytianos, G., Rahdar, A., & Kyzas, G. Z. (2020). Nanomaterials in cosmetics: recent updates. Nanomaterials, 10(5), 1–16. https://doi.org/10.3390/nano10050979

Gonçalves, C., Ferreira, N., & Lourenço, L. (2021). Production of low molecular weight chitosan and chitooligosaccharides (COS): A review. Polymers, 13(15), 1–23. https://doi.org/10.3390/polym1315 2466

Guo, D., Xie, G., & Luo, J. (2014). Mechanical properties of nanoparticles: basics and applications. Journal of Physics D: Applied Physics, 47(1), 1-25. https://doi.org/10.1088/0022-3727/47/1/013001

Haerani, A., Chaerunisa, A. Y., & Subranas, A. (2018). Artikel tinjauan: antioksidan untuk kulit. Farmaka, 16, 135–151. https://doi.org/10.24198/jf.v16i1

Hamed, I., Özogul, F., & Regenstein, J. M. (2016). Industrial applications of crustacean by-products (chitin, chitosan, and chitooligosaccharides): A review. Trends in Food Science and Technology, 48, 40–50. https://doi.org/10.1016/j.tifs.2015.11.007

Hartono, D., Sulasmi, A., Oktaviani, A. D., Ismanur, R. P., & Sipahutar, Y. H. (2021). Fortifikasi natrium alginat dan ekstrak lavender terhadap formulasi skin lotion. Prosiding Simposium Nasional Kelautan dan Perikanan, 8, 103–110.

Hoan, N. X., Anh, L. T., Ha, H. T., & Cuong, D. X. (2023). Antioxidant activities, anticancer activity, physico-chemistry characteristics, and acute toxicity of alginate/lignin polymer. Molecules, 28(5181), 1-16. https://doi.org/https://doi.org/10.3390/ molecules28135181

Hussain, M., Iman, M., & Maji, T. K. (2013). Determination of degree of deacetylation of chitosan and their effect on the release behavior of essential oil from chitosan and chitosan-gelatin complex. International Journal of Advanced Engineering Applications, 2(4), 4–12.

Imtihani, H. N., & Permatasari, S. N. (2020). Synthesis and characterization of chitosan from whiteleg shrimp waste (Litopenaeus vannamei). Simbiosa, 9(2), 129–137. http://dx.doi.org/10.33373/sim-bio.v9i2.2699

Jayanudin, J., Lestari, A. Z., & Nurbayanti, F. (2014). Pengaruh suhu dan rasio pelarut ekstraksi terhadap rendemen dan viskositas natrium alginat dari rumput laut cokelat (Sargassum sp.). Jurnal Integrasi Proses, 5, 51–55. http://dx.doi.org/10.36055/jip.v5i1.35

Kamisyah, S., Sapar, A., Brilliantoro, R., & Sayekti, E. (2020). Isolasi dan karakteristik alginat dari rumput laut (Sargassum polycystum) asal perairan Singkawang Kalimantan Barat. Jurnal Kimia Khatulistiwa, 8(3), 62–71.

Khajouei, R. A., Tounsi, L., Shahabi, N., Patel, A. K., & Abdelkafi, S. (2022). Properties and applications of alginate. Properties and Applications of Alginate, 20(364), 1–181. https://doi.org/10.5772/ intechopen.94635

Kok, J. M. L., & Wong, C. L. (2018). Physicochemical properties of edible alginate film from Malaysian Sargassum polycystum C. Agardh. Sustainable Chemistry and Pharmacy, 9(3) 87–94. https://doi.org/10.1016/j.scp.2018.07.001

Komi, D. E., & Hamblin, M. R. (2016). Chitin and chitosan: production and application of versatile biomedical nanomaterials. HHS Public Access, 4(3), 411–427. https://doi.org/10.2307/4145104

Kulka, K., & Sionkowska, A. (2023). Chitosan based materials in cosmetic applications: a review. Molecules, 28(4), 1-21. https://doi.org/10.3390/molecules28041817

Kumar, A., Choudhary, A., Kaur, H., Guha, S., Mehta, S., & Husen, A. (2022). Potential applications of engineered nanoparticles in plant disease management: a critical update. Chemosphere, 295, 133798. https://doi.org/https://doi.org/10.1016/j.chemosphere.2022.133798

Langit, N. T. P., Ridlo, A., & Subagiyo, S. (2019). Pengaruh konsentrasi alginat dengan gliserol sebagai plasticizer terhadap sifat fisik dan mekanik bioplastik. Journal of Marine Research, 8(3), 314–321. https://doi.org/10.14710/jmr.v8i3.25256

Lee, M. K., Ryu, H., Lee, J. Y., Jeong, H. H., Baek, J., Van, J. Y., Kim, M. J., Jung, W. K., & Lee, B. (2022). Potential beneficial effects of Sargassum spp. in skin aging. Marine Drugs, 20(8), 1–17. https://doi.org/10.3390/md20080540

Letocha, A., Miastkowska, M., & Sikora, E. (2022). Preparation and characteristics of alginate microparticles for food, pharmaceutical and cosmetic applications. Polymers, 14(18), 1-32. https://doi.org/10.3390/polym14183834

Letsiou, S., Koldiri, E., Beloukas, A., Rallis, E., & Kefala, V. (2024). Deciphering the effects of different types of sunlight radiation on skin function: a review. Cosmetics, 11(3), 1-19. https://doi.org/10.3390/ cosmetics11030080

Maharani, A. A., Husni, A., & Ekantari, N. (2017). Karakteristik natrium alginat rumput laut cokelat (Sargassum fluitans) dengan metode ekstraksi yang berbeda. Jurnal Pengolahan Hasil Perikanan Indonesia, 20(3), 478–487. https://doi.org/10.17844/jphpi.v20i3.19768

Melo, F. M., Mathur, A., Murugappan, S., Sharma, A., Tanwar, K., Dua, K., Singh, S. K., Mazzola, P. G., Yadav, D. N., Rengan, A. K., Veiga, F., & Santos, A. C. P. (2023). Inorganic nanoparticles in dermopharmaceutical and cosmetic products: properties, formulation development, toxicity, and regulatory issues. European Journal of Pharmaceutics and Biopharmaceutics, 192(9), 25–40. https://doi.org/10.1016/j.ejpb.2023.09.011

Mihranyan, A., Ferraz, N., & Strømme, M. (2012). Current status and future prospects of nanotechnology in cosmetics. Progress in Materials Science, 57(5), 875–910. https://doi.org/10.1016/j.pmatsci.2011. 10.001

Muhammad, M., Mohammad, S., Ketut, S. I., & Rahmatang. (2023). Environmental-friendly extraction methods to produce bioactive compounds in seaweed. Research Journal of Chemistry and Environment, 27(11), 114–121. https://doi.org/10.25303/2711rjce1140121

Nadia, L. M. H., Suptijah, P.-, & Ibrahim, B. (2014). Production and characterization chitosan nano from black tiger shrimpwith ionic gelation methods. Jurnal Pengolahan Hasil Perikanan Indonesia, 17(2), 119–126. https://doi.org/10.17844/jphpi.v17i2.8700

Natalia, D. A., Dharmayanti, N., & Dewi, F. R. (2021). The production of chitosan from crab shell (Portunus sp.) at room temperature. Jurnal Pengolahan Hasil Perikanan Indonesia, 24(3), 301–309. https://doi.org/10.17844/jphpi.v24i3.36635

Niculescu, A. G., & Grumezescu, A. M. (2022). Applications of chitosan-alginate-based nanoparticles- an up-to-date review. Nanomaterials, 12(2), 1-23. https://doi.org/10.3390/nano12020186

Nuryadin, D. F. ., Setyaningsih, I., & Hardiningtyas, S. D. (2020). Depolimerisasi kitosan menggunakan sinar ultraviolet dan katalis asam klorida. Jurnal Pengolahan Hasil Perikanan Indonesia, 23(3), 412–422. https://doi.org/10.17844/jphpi.v23i3.31656

Pakidi, C. S., & Suwoyo, H. S. (2016). Potensi dan pemanfaatan bahan aktif alga coklat. Octopus: Jurnal Ilmu Perikana, 5(2), 488–498.

Permadi, A., Afifah, R. A., Apriani, D. A. K., & Ariyani, F. (2022). Water soluble chitosan from green mussel (Perna viridis) shells and its use as fat-absorber in cookies. Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology, 17(3), 168–176. https://doi.org/10.15578/squalen.731

Permatasari, A. A. A. P., Rosiana, I. W., Wiradana, P. A., Lestari, M. D., Widiastuti, N. K., Kurniawan, S. B., & Widhiantara, I. G. (2022). Extraction and characterization of sodium alginate from three brown algae collected from Sanur Coastal Waters, Bali as biopolymer agent. Biodiversitas, 23(3), 1655–1663. https://doi.org/10.13057/biodiv/d230357

Pradhan, B., Bhuyan, P. P., Patra, S., Nayak, R., Behera, P. K., Behera, C., Behera, A. K., Ki, J.-S., & Jena, M. (2022). Beneficial effects of seaweeds and seaweed-derived bioactive compounds: Current evidence and future prospective. Biocatalysis and Agricultural Biotechnology, 39(2022), 1-10. https://doi.org/https://doi.org/10.1016/j.bcab.2021.102242

Pratasik, M. C. M., Yamlean, P. V. Y., & Wiyono, W. I. (2019). Formulasi dan uji stabilitas fisik sediaan krim ekstrak etanol daun sesewanua (Clerodendron squamatum Vahl.). Pharmacon, 8(2), 261-267. https://doi.org/10.35799/pha.8.2019.29289

Purwaningsih, S., Salamah, E., & Budiarti, T. A. (2014). Formulasi skin lotion dengan penambahan karagenan dan antioksidan alami dari Rhizopora mucronata Lamk. Jurnal Akuatika, 5(1), 55–62.

Rahmawanty, D., Annisa, N., & Sari, D. I. (2020). Formulation of cosmetic (ontioxidant lotion) from bangkal (Nauclea subdita (Korth.) Steud.). Prosiding Seminar Nasional Lingkungan Lahan Basah, 5(2), 25–29.

Raj, S., Jose, S., Sumod, U. S., & Sabitha, M. (2012). Nanotechnology in cosmetics: Opportunities and challenges. Journal of Pharmacy and Bioallied Sciences, 4(3), 186–193. https://doi.org/10.4103/ 0975-7406.99016

Reddy, M. R., & Gubbiyappa, K. S. (2022). Formulation development, optimization and characterization of Pemigatinib-loaded supersaturable self-nanoemulsifying drug delivery systems. Future Journal of Pharmaceutical Sciences, 8(1), 1-20. https://doi.org/10.1186/s43094-022-00434-4

Safitri, C. I., & Jubaidah, L. (2019). Formulasi dan uji mutu fisik sediaan lotion ekstrak kulit buah jagung (Zea mays L.). Jurnal Insan Farmasi Indonesia, 2(2), 175–184. https://doi.org/10.36387/ jifi.v2i2.394

Salsabila, N., Indratmoko, S., & O, A. T. N. L. (2020). Pengembangan hand & body lotion nanopartikel kitosan dan Spirulina Sp sebagai antioksidan. Jurnal Ilmiah JOPHUS : Journal of Pharmacy UMUS, 2(01), 11–20. https://doi.org/10.46772/jophus.v2i01.268

Salvioni, L., Morelli, L., Ochoa, E., Labra, M., Fiandra, L., Palugan, L., Prosperi, D., & Colombo, M. (2021). The emerging role of nanotechnology in skincare. Advances in Colloid and Interface Science, 293, 1-23. https://doi.org/10.1016/j.cis.2021.102437

Santos, A. C., Morais, F., Simões, A., Pereira, I., Sequeira, J. A. D., Pereira-Silva, M., Veiga, F., & Ribeiro, A. (2019). Nanotechnology for the development of new cosmetic formulations. Expert Opinion on Drug Delivery, Taylor & Francais, 16(4), 313–330. https://doi.org/10.1080/17425247 .2019.1585426

Santoso, J., Adiputra, K. C., Soerdirga, L. C., & Tarman, K. (2020). Effect of acetic acid hydrolysis on the characteristics of water soluble chitosan. IOP Conference Series: Earth and Environmental Science, 414(2020), 1-8. https://doi.org/10.1088/1755-1315/414/1/012021

Shang, Y., Hasan, K., Ahammed, G. J., Li, M., & Yin, H. (2019). Applications of nanotechnology in plant growth and crop protection: a review. Molecules, MDPI, 24(2558), 1–24. https://doi.org/ doi:10.3390/molecules24142558

Sipahutar, Y. H., Albaar, N., Purnamasari, H. B., Kristiany, M. G., & Prabowo, D. H. G. (2019). Seaweed extract (Sargassum polycystum) as a preservative on sunscreen cream with the addition of seaweed porridge. IOP Conference Series: Earth and Environmental Science, 278(2019), 1-8. https://doi.org/10.1088/ 1755-1315/278/1/012072

Sudianto, Heri Suseno, S., & Suptijah, P. (2020). Optimasi produksi kitosan larut air menggunakan metode hidrolisis bertekanan. Jurnal Pengolahan Hasil Perikanan Indonesia, 23(3), 441–446. https://doi.org/10.17844/jphpi.v23i3.30022

Sugiono, S., Masruri, M., Estiasih, T., & Widjanarko, S. B. (2019). Optimization of extrusion-assisted extraction parameters and characterization of alginate from brown algae (Sargassum cristaefolium). Journal of Food Science and Technology, 56(8), 3687–3696. https://doi.org/10.1007/s13197-019-03829-z

Sulasmi, A., Hartono, D., Oktaviani, A. D., Ismanur, R. P., & Sipahutar, Y. H. (2020). Formulasi skin lotion dengan penambahan natrium alginat dan ekstrak lavender. Prosiding Seminar Nasional Tahunan XVII Hasil Penelitian Perikanan dan Kelautan,Departemen Perikanan, Fakultas Pertanian, Universitas Gajah Mada Tahun 2020, 17, 414–420.

Sumandiarsa, I. K., Bengen, D. G., Santoso, J., & Januar, H. I. (2020). Nutritional composition and alginate characteristics of Sargassum polycystum (C. Agardh, 1824) growth in Sebesi island coastal, Lampung-Indonesia. IOP Conference Series: Earth and Environmental Science, 584(1), 0–12. https://doi.org/10.1088/1755-1315/584/1/012016

Sumandiarsa, I. K., Hamida, N., Santoso, J., & Tarman, K. (2022). Antioxidant activities from different parts of Sargassum polycystum thalli through ultrasound- assisted extraction (UAE) method. Omni-Akuatika, 18(2), 79–89. https://doi.org/http://dx.doi.org/10.20884/1.oa.2022.18.2.907

Tanasale, M. F. J. D. P., Bijang, C. M., & Rumpakwara, E. (2019). Preparation of chitosan with various molecular weight and its effect on depolymerization of chitosan with hydrogen peroxide using conventional technique. International Journal of ChemTech Research, 12(01), 112–120. https://doi.org/10.20902/ijctr.2019.120113

Tungtong, S., Okonogi, S., Chowwanapoonpohn, S., Phutdhawong, W., & Yotsawimonwat, S. (2012). Solubility, viscosity and rheological properties of water-soluble chitosan derivatives. Maejo International Journal of Science and Technology, 6(2), 315–322. https://doi.org/10.14456/mijst.2012.24

United States Pharmacopeial Convention. (2020). Food chemicals codex (12th ed.). The United States Pharmacopeial Convention.

Wu, Y., Tao, Q., Xie, J., Lu, L., Xie, X., Zhang, Y., & Jin, Y. (2023). Advances in nanogels for topical drug delivery in ocular diseases. Gels, MDPI, 9(4), 1-21. https://doi.org/10.3390/gels9040292

Xie, C., Lee, Z. J., Ye, S., Barrow, C. J., Dunshea, F. R., & Suleria, H. A. R. (2024). A review on seaweeds and seaweed-derived polysaccharides: nutrition, chemistry, bioactivities, and applications. Food Reviews International, 40(5), 1312–1347. https://doi.org/10.1080/87559129. 2023.2212055

Yadav, J., Jasrotia, P., Kashyap, P. L., Bhardwaj, A. K., Kumar, S., Singh, M., & Singh, G. P. (2020). Nanopesticides: Current status and scope for their application in agriculture. Plant Protection Science, 58(1), 1–17. https://doi.org/10.17221/102/2020-PPS

Yadav, M., Kaushik, B., Rao, G. K., Srivastava, C. M., & Vaya, D. (2023). Advances and challenges in the use of chitosan and its derivatives in biomedical fields: a review. Carbohydrate Polymer Technologies and Applications, 5(6), 1-22. https://doi.org/10.1016/j.carpta.2023.100323

You, C., Han, C., Wang, X., Zheng, Y., Li, Q., Hu, X., & Sun, H. (2012). The progress of silver nanoparticles in the antibacterial mechanism, clinical application and cytotoxicity. Molecular Biology Reports, 39(9), 9193–9201. https://doi.org/10.1007/s11033-012-1792-8

Yusharani, M. S., Stenley, Harmami, Ulfin, I., & Ni’Mah, Y. L. (2019). Synthesis of water-soluble chitosan from squid pens waste as raw material for capsule shell: Temperature deacetylation and reaction time. IOP Conference Series: Materials Science and Engineering, 509(2019), 1-11. https://doi.org/10.1088/1757-899X/509/1/012070

Downloads

Published

2025-12-03

How to Cite

Sipahutar, Y. H., Prayudi, A. ., Handoko, Y. P. ., Lisandry, M. ., Sayuti, M. ., Siregar, A. N. ., Samanta, P. N. ., & Sitorus, P. P. R. . (2025). Characteristics of body lotion from chitosan and alginate (Sargassum sp.) nanoparticles: Karakteristik produk body lotion dari nanopartikel kitosan dan alginat (Sargassum sp.). Jurnal Pengolahan Hasil Perikanan Indonesia, 28(11). https://doi.org/10.17844/em1wpf70