Daun dan Biji Srikaya (Annona squamosa L.) dan Potensinya sebagai Antikanker
Keywords:
Annona squamosa, antikanker, srikaya
Abstract
Srikaya (Annona squamosa) secara tradisional sudah lama digunakan untuk mengobati berbagai penyakit. Potensi senyawa-senyawa dalam srikaya sebagai antikanker membuat daun dan biji srikaya sering digunakan sebagai obyek penelitian. Tulisan ini memuat beberapa hasil penelitian daun dan biji srikaya sebagai antikanker baik secara in vitro maupun in vivo. Penelusuran kepustakaan menggunakan peramban Google Scholar, Scopus, PubMed, ScienceDirect, dan SpringerLink. Srikaya memiliki senyawa yang berpotensi seperti diterpene, alkaloid, acetogenin, siklopeptida, flavonoid, tannin, dan saponin sebagai kandidat antikanker. Daun dan biji srikaya terbukti memiliki aktivitas antikanker Studi lebih lanjut tentang mekanisme aktivitas antikanker terhadap setiap senyawa yang berperan sebagai antikanker sangat penting dilakukan agar dapat dijadikan sebagai rerefensi yang utuh dalam penerapan ilmu farmasi, biomedis ataupun pertanian.
References
[1] Siegel, R.L., Miller, K.D., Fuchs, H.E. & Jemal, A. (2021). Cancer statistics, 2021. CA Cancer J. Clin., 71(1), 7-33.
[2] Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A. & Bray F. (2023). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 71(3), 209-249.
[3] Bray, F., Ferlay J., Soerjomataram, I, Siegel, R.I., Torre, L.A. & Jemal, A. (2018). Global cancer statistic 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 68(6), 394-424.
[4] Delon, C., Brown, K.F., Payne, N.W.S., Kotrotsios, Y., Vernon, S. & Shelton, J. (2022). Differences in cancer incidence by broad ethnic group in England, 2013-2017. British Journal of Cancer, 126, 1765-1773.
[5] Sulistyoningrum, E., Rachmani, E.P.N., Baroroh, H.N. & Rujito, L. (2017). Annona muricata leaves extract reduce proliferative indexes and improve histological changes in rat’s breast cancer. J. Appl. Pharm. Sci., 7(1), 149-155.
[6] Kennedy, L.B. & Salama, A.K.S. (2020). A review of cancer immunotheraphy toxicity. CA Cancer J. Clin., 70(2),86-104.
[7] Drasar, P.B. & Khripach, V.A. (2019). Growing importance of natural products research. Molecules, 25(1), 6.
[8] Batubara, I. & Prastya, M.E. (2020). Potential use of Indonesian medicinal plants for cosmetics and oral health: a review. Jurnal Kimia Valensi, 6(1), 120-134.
[9] Ma, C., Chen, Y., Chen, J., Li, X. & Chen, Y. (2017). A review on Annona squamosa L.: phytochemicals and biological activities. Am. J. Chin. Med., 45(5), 933-964.
[10] Abd-Elghany, A.A., Ahmed, S.M., Masoud, M.A., Atia, T., Waggiallah, H.A., El-Sakhawy, M.A. & Mohamad E.A. (2022). Annona squamosa L. extract-loaded noisome and its anti-ehrlich ascites’ carcinoma activity. ACS Omega, 7(43), 38436-38447.
[11] Kumar, M., Changan, S., Tomar, M., Prajapati, U., Saurabh, V., Hasan, M., Sasi, M., Maheswari, C., Singh, S., Dhumal, S., Radha, Takur, M., Punia, S., Satankar, V., Amarowicz, R. & Mekhemar, M. (2021). Custard apple (Annona squamosa L.) leaves: nutritional, composition, phytochemical profile, and health-promoting biological activities. Biomolecules, 11, 614.
[12] Kusumardiyani, S., Wandasari, F. & Wirasutisna, K.R. 2012. Telaah fitokimia daun srikaya (Annona squamosa L.) yang berasal dari dua lokasi tumbuh. Acta Pharmaceutica Indonesia, 37(1), 9-13.
[13] Taufika, R., Nugroho, S.A. & Nuraisyah, A. (2021). Efektivitas campuran ekstrak daun srikaya (Annona squamosa L.) dan rimpang kunyit (Curcuma domestica Val.) pada moratalitas larva spodoptera litura F. (Lepidoptera: Nuctuidae). Jurnal Ilmu Pertanian Indonesia, 26(1), 32-41.
[14] Devar, A. & Joseph, S.M. (2021). Anticancer potential of Annona genus: a detailed review. Journal of the Indian Chemical Society, 98, 100231.
[15] Tansil, A.Y.M., Nangoy, E., Posangi, J., Bara, R.A. (2016). Uji daya hambat ekstrak etanol daun srikaya (Annona squamosa) terhadap pertumbuhan bakteri Eschericia coli dan Staphylococcus aureus. Jurnal e-Biomedik (eBm), 4(2).
[16] Sun, L.R., Zhu, H., Gan, L.S., Mo, J.X., Fenf, F. & Zhou, C.X. (2012). Constituents from the bark of Annona squamosa and their anti-tumor activity. China J. Chin. Mater. Med., 37, 2100-2104.
[17] Pedro, N., Cautain, B., Melguizo, A., Vicente, F., Genilloud, O., Pelaez, F. & Tormo, J.R. (2013). Mitochondrial complex I inhibitors acetogenins, induce HepG2 cell death through the induction of the complete apoptotic mitochondrial pathway. J. Bioenerg. Biomembr., 45(1-2), 153-164.
[18] Ramadhani, D., Maharani, R., Gazzali, A.M. & Muchtaridi, M. (2022). Cyclic peptides for the treatment of cancers: a review. Molecules, 27(14),4428.
[19] Meira, C.S., Guimaraes, T.S., da Silva, T.B., Menezes, L.R., Costa, E.V. & Soares, M.B. (2015). Chemical composition of essential oil from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalaria and trypanocidal activities. J. Essent. Oil Res., 27,160-168.
[20] Reddy, C.R., Reddy, M.D. & Dilipkumar, U. (2014). Total synthesis of a pyrolle lactone alkaloid, longanlactine. European J. Org. Chem., 2014(28), 1183-1189.
[21] Safira, A., Widayani, P., An-Najaaty, D., Rani, C.A.M., Septiani, M., Putra, Y.A.S., Solikhah, T.I., KHairullah, A.R. & Raharjo, H.M. (2022). A review of an important plants: Annona squamosa leaf. Pharmacogn J. 14(2), 456-463.
[22] Fadholly, A., Proboningrat A., Iskandar, R.P.D., Rantam, F.A. & Sudjarwo, S.A. (2018). In vitro anticancer activity Annona squamosa extract nanoparticle on WiDr cells. J. Adv. Pharm. Technol. Reseacrh, 10, 149-154
[23] Fadholly, A., Ansori, A.N.M., Proboningrat, A., Nugraha, A.P., Iskandar, R.P.D., Rantam. F.A. & Sudjarwo, S.A. (2019). Apoptosis of HeLa cells via caspase-3 expression induced by chitosan-based nanoparticles of Annona squamosa leaf extract: in vitro study. Indian Journal of Pharmaceutical Education and Research, 54(2), 416-421.
[24] Vivek R., Thangnam, R., Muthuchelian, K., Gunasekaran, P., Kaveri & Kannan, S. (2012). Green biosynthesis of silver nanoparticles from Annona squamosa leaf extract and it’s in vitro cytotoxic effect on MCF-7 cell. Process Biochem., 47, 2405-2410.
[25] Ruddaraju, L.K., Vijaykumar, P.P.N., Pammi, S.V.M., Swamy, P.V. & Murthy, K.V.R. (2019). Synergetic antibacterial and anticarcinogenic effects of Annona squamosa leaf extract mediated silver nanoparticles. Mater. Sci. Semicond. Process., 100, 301-309.
[26] Agrawal, R.C., Snehal, S. & Maheshwari, S.K. (2018). Chemopreventive potential of Annona squamosa leaves extract in swiss albino mice. Int. J. Mod. Biol. Res., 1, 1-8.
[27] Vikas, B., Anil, S. &Remani, P. (2019). Cytotoxicity profiling of Annona squamosa on MCF-7 cell-line. J. Pharmacogn. Phytotherapy, 8, 147-154.
[28] Chen, Y., Chen, J.W., Zhau, J.H., Wang, Y., Wang, S.L. & Li, X. (2013). Antitumor activity and toxicity relationship of annonaceous acetogenins. Food Chem. Toxicol. 58, 394-400.
[29] Ma, C, Wang, Q., Shi, Y., Li, Y., Wang X., Li, X., Chen, Y. & Chen, J. (2017). Three new antitumor annonaceous acetogenins from seeds of Annonaa squamosa. Nat. Prod. Res., 31, 2085-2090.
[30] Al-Ghazali, A.M. (2019). Anti-cancer activity of new benzyl isoquinoline alkaloid from Saudi plant Annona squamosa. BMC Chem., 13.
[31] Chen, Y., Chen, J.W., Wang, Y., Xu, S.S. & Li, X. (2012) Six cytotoxic annonaceous acetogenins from Annona squamosa seeds. Food Chem., 135, 960-966.
[32] Miao, Y., Xu, X., Yuan, F., Shi, Y., Chen, Y., Chen, J. & Li, X. Four cytotoxic annonaceous acetogenins from seeds of Annona squamosa. Nat. Prod. Res., 30, 1273-1279.
[33] Chen, Y., Shiy, Y., Ma, C., Wang, X., Li, Y., Miao, Y., Chen, J. & Li, X. (2016). Antitumor activity of Annona squamosa seed oil. J. Ethnopharmacol.,193, 362-267.
[2] Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A. & Bray F. (2023). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 71(3), 209-249.
[3] Bray, F., Ferlay J., Soerjomataram, I, Siegel, R.I., Torre, L.A. & Jemal, A. (2018). Global cancer statistic 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 68(6), 394-424.
[4] Delon, C., Brown, K.F., Payne, N.W.S., Kotrotsios, Y., Vernon, S. & Shelton, J. (2022). Differences in cancer incidence by broad ethnic group in England, 2013-2017. British Journal of Cancer, 126, 1765-1773.
[5] Sulistyoningrum, E., Rachmani, E.P.N., Baroroh, H.N. & Rujito, L. (2017). Annona muricata leaves extract reduce proliferative indexes and improve histological changes in rat’s breast cancer. J. Appl. Pharm. Sci., 7(1), 149-155.
[6] Kennedy, L.B. & Salama, A.K.S. (2020). A review of cancer immunotheraphy toxicity. CA Cancer J. Clin., 70(2),86-104.
[7] Drasar, P.B. & Khripach, V.A. (2019). Growing importance of natural products research. Molecules, 25(1), 6.
[8] Batubara, I. & Prastya, M.E. (2020). Potential use of Indonesian medicinal plants for cosmetics and oral health: a review. Jurnal Kimia Valensi, 6(1), 120-134.
[9] Ma, C., Chen, Y., Chen, J., Li, X. & Chen, Y. (2017). A review on Annona squamosa L.: phytochemicals and biological activities. Am. J. Chin. Med., 45(5), 933-964.
[10] Abd-Elghany, A.A., Ahmed, S.M., Masoud, M.A., Atia, T., Waggiallah, H.A., El-Sakhawy, M.A. & Mohamad E.A. (2022). Annona squamosa L. extract-loaded noisome and its anti-ehrlich ascites’ carcinoma activity. ACS Omega, 7(43), 38436-38447.
[11] Kumar, M., Changan, S., Tomar, M., Prajapati, U., Saurabh, V., Hasan, M., Sasi, M., Maheswari, C., Singh, S., Dhumal, S., Radha, Takur, M., Punia, S., Satankar, V., Amarowicz, R. & Mekhemar, M. (2021). Custard apple (Annona squamosa L.) leaves: nutritional, composition, phytochemical profile, and health-promoting biological activities. Biomolecules, 11, 614.
[12] Kusumardiyani, S., Wandasari, F. & Wirasutisna, K.R. 2012. Telaah fitokimia daun srikaya (Annona squamosa L.) yang berasal dari dua lokasi tumbuh. Acta Pharmaceutica Indonesia, 37(1), 9-13.
[13] Taufika, R., Nugroho, S.A. & Nuraisyah, A. (2021). Efektivitas campuran ekstrak daun srikaya (Annona squamosa L.) dan rimpang kunyit (Curcuma domestica Val.) pada moratalitas larva spodoptera litura F. (Lepidoptera: Nuctuidae). Jurnal Ilmu Pertanian Indonesia, 26(1), 32-41.
[14] Devar, A. & Joseph, S.M. (2021). Anticancer potential of Annona genus: a detailed review. Journal of the Indian Chemical Society, 98, 100231.
[15] Tansil, A.Y.M., Nangoy, E., Posangi, J., Bara, R.A. (2016). Uji daya hambat ekstrak etanol daun srikaya (Annona squamosa) terhadap pertumbuhan bakteri Eschericia coli dan Staphylococcus aureus. Jurnal e-Biomedik (eBm), 4(2).
[16] Sun, L.R., Zhu, H., Gan, L.S., Mo, J.X., Fenf, F. & Zhou, C.X. (2012). Constituents from the bark of Annona squamosa and their anti-tumor activity. China J. Chin. Mater. Med., 37, 2100-2104.
[17] Pedro, N., Cautain, B., Melguizo, A., Vicente, F., Genilloud, O., Pelaez, F. & Tormo, J.R. (2013). Mitochondrial complex I inhibitors acetogenins, induce HepG2 cell death through the induction of the complete apoptotic mitochondrial pathway. J. Bioenerg. Biomembr., 45(1-2), 153-164.
[18] Ramadhani, D., Maharani, R., Gazzali, A.M. & Muchtaridi, M. (2022). Cyclic peptides for the treatment of cancers: a review. Molecules, 27(14),4428.
[19] Meira, C.S., Guimaraes, T.S., da Silva, T.B., Menezes, L.R., Costa, E.V. & Soares, M.B. (2015). Chemical composition of essential oil from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalaria and trypanocidal activities. J. Essent. Oil Res., 27,160-168.
[20] Reddy, C.R., Reddy, M.D. & Dilipkumar, U. (2014). Total synthesis of a pyrolle lactone alkaloid, longanlactine. European J. Org. Chem., 2014(28), 1183-1189.
[21] Safira, A., Widayani, P., An-Najaaty, D., Rani, C.A.M., Septiani, M., Putra, Y.A.S., Solikhah, T.I., KHairullah, A.R. & Raharjo, H.M. (2022). A review of an important plants: Annona squamosa leaf. Pharmacogn J. 14(2), 456-463.
[22] Fadholly, A., Proboningrat A., Iskandar, R.P.D., Rantam, F.A. & Sudjarwo, S.A. (2018). In vitro anticancer activity Annona squamosa extract nanoparticle on WiDr cells. J. Adv. Pharm. Technol. Reseacrh, 10, 149-154
[23] Fadholly, A., Ansori, A.N.M., Proboningrat, A., Nugraha, A.P., Iskandar, R.P.D., Rantam. F.A. & Sudjarwo, S.A. (2019). Apoptosis of HeLa cells via caspase-3 expression induced by chitosan-based nanoparticles of Annona squamosa leaf extract: in vitro study. Indian Journal of Pharmaceutical Education and Research, 54(2), 416-421.
[24] Vivek R., Thangnam, R., Muthuchelian, K., Gunasekaran, P., Kaveri & Kannan, S. (2012). Green biosynthesis of silver nanoparticles from Annona squamosa leaf extract and it’s in vitro cytotoxic effect on MCF-7 cell. Process Biochem., 47, 2405-2410.
[25] Ruddaraju, L.K., Vijaykumar, P.P.N., Pammi, S.V.M., Swamy, P.V. & Murthy, K.V.R. (2019). Synergetic antibacterial and anticarcinogenic effects of Annona squamosa leaf extract mediated silver nanoparticles. Mater. Sci. Semicond. Process., 100, 301-309.
[26] Agrawal, R.C., Snehal, S. & Maheshwari, S.K. (2018). Chemopreventive potential of Annona squamosa leaves extract in swiss albino mice. Int. J. Mod. Biol. Res., 1, 1-8.
[27] Vikas, B., Anil, S. &Remani, P. (2019). Cytotoxicity profiling of Annona squamosa on MCF-7 cell-line. J. Pharmacogn. Phytotherapy, 8, 147-154.
[28] Chen, Y., Chen, J.W., Zhau, J.H., Wang, Y., Wang, S.L. & Li, X. (2013). Antitumor activity and toxicity relationship of annonaceous acetogenins. Food Chem. Toxicol. 58, 394-400.
[29] Ma, C, Wang, Q., Shi, Y., Li, Y., Wang X., Li, X., Chen, Y. & Chen, J. (2017). Three new antitumor annonaceous acetogenins from seeds of Annonaa squamosa. Nat. Prod. Res., 31, 2085-2090.
[30] Al-Ghazali, A.M. (2019). Anti-cancer activity of new benzyl isoquinoline alkaloid from Saudi plant Annona squamosa. BMC Chem., 13.
[31] Chen, Y., Chen, J.W., Wang, Y., Xu, S.S. & Li, X. (2012) Six cytotoxic annonaceous acetogenins from Annona squamosa seeds. Food Chem., 135, 960-966.
[32] Miao, Y., Xu, X., Yuan, F., Shi, Y., Chen, Y., Chen, J. & Li, X. Four cytotoxic annonaceous acetogenins from seeds of Annona squamosa. Nat. Prod. Res., 30, 1273-1279.
[33] Chen, Y., Shiy, Y., Ma, C., Wang, X., Li, Y., Miao, Y., Chen, J. & Li, X. (2016). Antitumor activity of Annona squamosa seed oil. J. Ethnopharmacol.,193, 362-267.
Published
2023-03-10
How to Cite
FadhollyA. (2023). Daun dan Biji Srikaya (Annona squamosa L.) dan Potensinya sebagai Antikanker. Jurnal Veteriner Dan Biomedis, 1(1), 45-50. https://doi.org/10.29244/jvetbiomed.1.1.45-50.
Section
Articles
Copyright (c) 2023 Amaq Fadholly
This work is licensed under a Creative Commons Attribution 4.0 International License.
