Prediction of insulin resistance in late adolescent based on anthropometric index

Addina Rizky Fitriyanti, Muhammad Sulchan, Kusmiyati Tjahjono, Sunarto Sunarto


The study aimed to evaluate the role of neck circumference for predicting insulin resistance in adolescent compared with waist circumference and waist hip ratio. A cross sectional study was conducted by measuring anthropometric parameters (neck circumference, waist circumference, hip circumference) and biochemical parameter (fasting plasma glucose, fasting insulin, and HOMA-IR) involving 80 late adolescents. Statistical analysis used in this study were Pearson and Spearman correlation, multivariate linear regression. Neck circumference positively correlated with fasting insulin and HOMA-IR in both gender, while neck circumference only positively correlated with fasting plasma glucose in men. In addition, multivariate linier regression showed that a higher regression coefficient of waist circumference associated with a higher risk of insulin resistance (fasting insulin (β=0.11; p<0.05), HOMA-IR (β=0.05; p<0.05)) compared to neck circumference and waist hip ratio. Neck circumference, waist circumference, and waist hip ratio is an anthropometry indicators that could be used to predict insulin resistance.  However, waist circumference is better than neck circumference and waist hip ratio for predicting insulin resistance in adolescent.


Caprio S, Perry R, Kursawe R. 2017. Adolescent obesity and insulin resistance: roles of ectopic fat accumulation and adipose inflammation. Gastroenterology 152(7):1638–1646.

Dahlan, MS. 2009. Analisis Penelitian Diagnostik. Penelitian Diagnostik. Jakarta: Salemba Medika.

Dai Y. Wan X, Li X, Jin E, Li X. 2016. Neck circumference and future cardiovascular events in a high-risk population-A prospective cohort study. Lipids in health and disease. 15(1):46.

Dewi M. 2007. Resistensi insulin terkait obesitas: mekanisme endokrin dan intrinsik sel. J.Gizi Pangan 2(2):49-54.

Ferretti RDL, Cintra IDP, Passos MAZ, Ferrari GLDM, Fisberg M. 2015. Elevated neck circumference and associated factors in adolescents. BMC Public Health 15(28):1-10.

Gomez-Arbelaez D, Camacho PA, Cohen, DD, Saavedra-Cortes S. Lopez-Lopez C, Lopez-Jaramillo P. 2016. Neck circumference as a predictor of metabolic syndrome, insulin resistance and low-grade systemic inflammation in children: the ACFIES study. BMC pediatrics 16(1):31.

Hatipoglu N, Mazicioglu MM, Kurtoglu S, Kendirci M. 2010. Neck circumference: an additional tool of screening overweight and obesity in childhood. Eur J Pediatr 169(6):733-739.

Hingorjo MR, Zehra S, Imran E, Qureshi MA. 2016. Neck circumference: a supplemental tool for the diagnosis of metabolic syndrome. JPMA 66(10):1221-1226.

Joshipura K, Muñoz-Torres F, Vergara J, Palacios C, Pérez, CM. 2016. Neck circumference may be a better alternative to standard anthropometric measures. J Diabetes Res 2016:1–8.

Junge J, Engel C, Vogel M, Naumann S, Löffler M, Thiery J, Kratzsch J, Kiess W, Körner A. 2017. Neck circumference is similarly predicting for impairment of glucose tolerance as classic anthropometric parameters among healthy and obese children and adolescents. J Pediatr Endocrinol Metab 30(6):643-650.

Kautzky-Willer, A, Harreiter J, Pacini G. 2016. Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus. Endocrine Reviews 37(3):278–316.

Kelishadi R, Heidari-Beni M, Qorbani M, Motamed-Gorji N, Motlagh ME, Ziaodini H, Taheri M, Ahadi Z, Aminaee T, Heshmat R. 2017. Association between neck and wrist circumferences and cardiometabolic risk in children and adolescents: The CASPIAN-V study. Nutrition 43:32-38.

Li HX, Zhang F, Zhao D, Xin Z, Shu-Qin G, Shu-Mei W, Jian-Jun Z, Wang J, Li Y, Guang-Ran Y, Jin-Kui Y. 2014. Neck circumference as a measure of neck fat and abdominal visceral fat in Chinese adults. BMC public health 14(1):311.

Luo Y, Ma X, Shen Y, Xu Y, Xiong Q, Zhang X, Xiao Y, Bao Y, Jia W. 2017. Neck circumference as an effective measure for identifying cardio-metabolic syndrome: a comparison with waist circumference. Endocrine, 55(3), pp.822-830.

Lysen LK, Israel DA, 2018. Nutrition in Weight Management, in Mahan L K and Raymond JL Krause’s Food and The Nutrition Care Process: 14th ed. Canada: Elsevier Inc

Ma C, Wang R, Liu Y, Lu Q, Liu X, Yin F. 2016. Diagnostic performance of body mass index to identify obesity as defined by body adiposity in children and adolescents: A systematic review and meta-analysis. Annals of Human Biology:1–7.
Meiliana A, Wijaya A. 2013. Perivascular Adipose Tissue and Cardiometabolic Disease. Indones Biomed J 5(1):13–24.

Namazi N, Larijani B, Surkan PJ, Azadbakht L. 2018. The association of neck circumference with risk of metabolic syndrome and its components in adults: A systematic review and meta-analysis. Nutr Metab Cardiovasc Dis 28(7):657-674.

Newbern D et al. 2014. Sex differences in biomarkers associated with insulin resistance in obese adolescents: metabolomic profiling and principal components analysis. Int J Clin Endocrinol Metab 99(12):4730–4739.

Jaksic, V.P., Grizelj, D., Livun, A., Boscic, D., Ajduk, M., Kusec, R. and Jaksic, O., 2018. Neck adipose tissue–tying ties in metabolic disorders. Horm Mol Biol Clin Investig 33(2).

Silva CDCD, Zambon MP, Vasques ACJ, Rodrigues AMDB, Camilo DF, Antonio MÂR, Cassani RSL, Geloneze B. 2014. Neck circumference as a new anthropometric indicator for prediction of insulin resistance and components of metabolic syndrome in adolescents: Brazilian Metabolic Syndrome Study. Revista Paulista de Pediatria 32(2): 221-229.

Stabe C, Vasques ACJ, Lima MMO, Tambascia MA, Pareja JC, Yamanaka A, Geloneze B. 2013. Neck circumference as a simple tool for identifying the metabolic syndrome and insulin resistance: results from the Brazilian Metabolic Syndrome Study. Clinical endocrinology 78(6):874-881.

Straznicky NE, Grima MT, Sari CI, Eikelis N, Nestel PJ, Dixon JB, Lambert GW, Schlaich MP, Phillips SE, Lambert EA . 2017. Neck circumference is associated with muscle sympathetic nerve activity in overweight and obese men but not women. Front Physiol 8:203.

Zhao L, Huang G, Xia F, Li Q, Han B, Chen Y, Chen C, Lin D, Wang N, Lu Y 2018. Neck circumference as an indicator of obesity in young adults. Lipids in Health and Disease 11(3):390–392.


Addina Rizky Fitriyanti (Primary Contact)
Muhammad Sulchan
Kusmiyati Tjahjono
Sunarto Sunarto
FitriyantiA. R., SulchanM., TjahjonoK., & SunartoS. (2019). Prediction of insulin resistance in late adolescent based on anthropometric index. Jurnal Gizi Dan Pangan, 14(2), 53-60.

Article Details

List of Cited By :

Crossref logo