Torbangun Leaves (Coleus amboinicus Lour) Powder Capsules Supplementation Improve Lipid Profile and Blood Pressure in Men with Hypercholesterol
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Issue
Vol. 13 No. 2 (2018)
Accepted
6 July 2018
Published
16 July 2018
Keywords:
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antioxidant, cholesterol, lipid profile, sistolic blood pressure, torbangun leaves
Abstract
The aim of this study was to analyze the effect of torbangun leaves powder capsules supplementation on lipid profile and blood pressure in men with hypercholesterol. This study was a single blind randomized control trial design with 26 male subjects. The inclusion criterias for subject were adults (age 25-55 years), blood total cholesterol levels ≥200 mg/dl, and signed the informed consent. Subjects were divided into two groups of one intervention (torbangun capsules) and one control (amylum) group. The intervention of 750 mg/day torbangun powder for the intervention group and 300 mg/day amylum for control group were administered for 28 days. The analysis of lipid profile results showed that the trygliseride, LDL, and HDL were not significantly affected by the torbangun intervention but it significantly decreased the total cholesterol level. The supplementation of torbangun capsules also decreased the sistolic blood pressure significantly. but not in diastolic pressure.
References
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Ardalan M, Rafieian-Kopaei M. 2014. Antioxidant supplementation in hypertension. J Renal Inj Prev 3(2):39-40.
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Baba S, Naomi O, Yoji K, Midori N, Akiko Y, Toshimi K, Kumiko F, Yuko M, Kazuo K. 2007. Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans. Am J Clin Nutr 85:709-717.
Baradaran A, Nasri H, Rafieian-Kopaei m. 2014. Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants. J Res Med Sci 19(4):358-367.
Batubara I, Kotsuka S, Yamauchi, Kuspradini H, Mitsunaga T, Darusman LK. 2012. Produksi TNF-α aktivitas penghambatan, fenolik, flavonoid, tanin, dan isi tanaman obat Indonesia yang dipilih. Research Journal of Medicinal Plant 6:406-415.
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Erejuwa OO, Sulaiman SA, Wahab MSA, Sirajudeen KN, Salleh MSM, Gurtu S. 2011. Differential responses to blood pressure and oxidative stress in streptozotocin-induced diabetic wistar kyoto rats and spontaneously hypertensive rats: effects of antioxidant (honey) treatment. Int J Mol Sci 12(3):1888-1907.
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Gengatharan A, Dykes GA, Choo WS. 2015. Betalains: Natural plant pigments with potential application in functional foods. Food Sci Technol Int 64:645-649.
Guo M, Liu Y, Gao Y, Shi D. 2014. Chinese herbal medicine on dyslipidemia: progress and perspective. ECAM 2014 (ID 163036). doi:10.1155/2014/163036.
Helmizar, Jalal F, Liputo I. 2010. Antioksidan dalam masakan minang dan potensi protektif terhadap risiko penyakit kardiovaskular. JAKA 4(1):13-20.
Herrera M, Rodriguez O, Torregrosa L, Vasquez M, Blanco E, Calderon L. 2016. Traditional use of plants as antihypertensive in Jipijapa, Manab & Iacute; Comparison with the literature. In Proceedings of the MOL2NET. International Conference on Multidisciplinary Sciences. 25 December 2016-25 January 2017; Sciforum Electronic Conference Series 2. doi:10.3390/mol2net-02-03890.
Hsieh PC, Huang GJ, Ho YL, Lin YH, Huang SS. 2010. Activities of antioxidants. α-glukosidase inhibitors and aldose reductase inhibitors of the aqueous extracts of four Flemingia species in Taiwan. Botanical Studies 51:293-302.
Hu FB, Manson JE, Willet WC. 2001. Types of dietary fat and risk of coronary heart disease. J Am Coll Nutr 20(1):5-19.
[Kemenkes RI] Kementrian Kesehatan Republik Indonesia. 2014. Situasi Kesehatan Jantung. Jakarta: Pusat Data dan Informasi Kesehatan Jantung Kemenkes. Jakarta: Kemenkes.
Lukacinova A, Mojzis J, Benacka R, Keller J, Maguth T, Kurila P, Vasko L, RaczO, Nistiar F. 2008. Preventive effects of flavonoids on Alloxan-induced diabetes mellitus in rats. J Acta Vet Brno 77(2):175-182.
Nadernejad N, Ahmadimoghadam A, Hosseinifard J, Pourseyedi S. 2012. Phenylalanin ammonialyase activity, total phenolic and flavonoid content in flowers, leaves, hulls, and kernels of three pistachio (Pistaciavera L.) cultivars. American-Eurasian J Agric Environ Sci 12(6):807-814.
Roshan DP, Naveen KM, Manjul PS, Anita S, Naheed WS, Gulzar A, Sudarshan KS. 2010. Antioxidant potential of leaves of Plectranthus amboinicus (Lour) Spreng. Der Pharmacia Lettre 2(4):240-245.
Smeltzer CS. Bare GB. 2001. Buku Ajar Keperawatan Medikal Bedah edisi 8. Jakarta: EGC.
Sharma SB, Nasir A, Prabhu KM, Murthy PS, Dev G. 2003. Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of eugenia jambolana in alloxan induced diabetic rabbits. J Ethnopharmacol 85(2):201-206.
Shenoy S, Kumar H, Thashma, Nayak V, Prabhu K, Pai P. 2012. Hepatoprotective activity of Plectranthus amboinicus against Paracetamol induced hepatotoxicity in rats. Int J of Pharm Sci 1(2):32-38.
Suryowati T, Rimbawan, Damanik R, Bintang M, Handharyani E. 2015. Antihyperlipidemic activity of Torbangun extract (Coleusam boinicuslour) on diabetic rats induced by streptozotocin. IOSR J Pharm Biol Sci 5(1):50-64.
Suryowati T, Rimbawan, Damanik R, Bintang M, Handharyani E. 2015. Identifikasi komponen kimia dan aktivitas antioksidan dalam tanaman Torbangun (Coleus amboinicus Lour). J Gizi Pangan 10(3):217-224.
Syam FM, Lubis Z, Siregar MA. 2013. Gambaran asupan zat gizi, status gizi, dan produktivitas kerja pada pekerja pabrik kelapa sawit Bagerpang Estate PT. PP. LONSUM 2013. GKRE 2(5):1-9.
Viswanathaswamy AHM, Koti BC, Gore A, Thippeswamy AHM, Kulkarni RV. 2011. Antihyperglycemic and antihyperlipidemi activity of plactranthusamboinicus on normal and alloxanindiced diabetic rats. Indian J Pharm Sci 73(2):139-145.
[WHO] World Health Organization. 2014. Global Status Report on Noncommunicable Disease 2014. available on http://apps.who.int/iris/bitstream/10665/148114/1/9789241564854_eng.pdf?ua= (accessed 4th of November 2016).
Yadav JP, Sushila S, Kalia AN, Dangi AS. 2008. Hypoglycemic and hypolipidemic activity of ethanolic extract of Salvadora oleoides in normal and alloxan induced diabetic rats. Indian J Pharm Sci 40:23-27.
Andriani E, Damanik R, Ekayanti I. 2012. Correlation of torbangun leaves (Coleus amboinicus Lour.) powder capsules suplementation on blood pressure and cholesterol. J Tek Ind Boga 3(1):14-22.
Ardalan M, Rafieian-Kopaei M. 2014. Antioxidant supplementation in hypertension. J Renal Inj Prev 3(2):39-40.
Assmann G, Gotto AM. 2004. HDL cholesterol and protective factors in atherosclerosis. Circulation 109:III-8-III-14. doi:10.1161/01.CIR.0000131512.50667.46.
Atef EAE. 2011. Quercetin protective action on oxidative stress, sorbitol, insulin resistance and β-cells function in experimental diabetic rats. Int J Pharm Stud Res 2(2):11-18.
Baba S, Naomi O, Yoji K, Midori N, Akiko Y, Toshimi K, Kumiko F, Yuko M, Kazuo K. 2007. Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans. Am J Clin Nutr 85:709-717.
Baradaran A, Nasri H, Rafieian-Kopaei m. 2014. Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants. J Res Med Sci 19(4):358-367.
Batubara I, Kotsuka S, Yamauchi, Kuspradini H, Mitsunaga T, Darusman LK. 2012. Produksi TNF-α aktivitas penghambatan, fenolik, flavonoid, tanin, dan isi tanaman obat Indonesia yang dipilih. Research Journal of Medicinal Plant 6:406-415.
Chang CLT, Lin Y, Arlene PB, Chen YC, Chiu SC, Yang WC. 2013. Herbal therapies for type 2 diabetes mellitus: chemistry, biology, and potential application of selected plants and compounds. Evid Based Complement Alternat Med 13(3):1-33. doi:10.1155/2013/378657.
Choi JW, Pai SH, Kim SK. 2002. Associations between total body fat and serum lipid concentrations in obese human adolescents. Annals of Clinical & Laboratory Science 32(3):271-278.
[Depkes RI] Departemen Kesehatan Republik Indonesia. 2007. Pedoman Pengendalian Penyakit Jantung dan Pembuluh Darah. Direktorat Jenderal Pengendalian Penyakit dan Penyehatan Lingkungan. Jakarta:Depkes RI.
Djohan TB. 2004. Penyakit Jantung Koroner dan Hipertensi. Medan: Universitas Sumatera Utara.
Erejuwa OO, Sulaiman SA, Wahab MSA, Sirajudeen KN, Salleh MSM, Gurtu S. 2011. Differential responses to blood pressure and oxidative stress in streptozotocin-induced diabetic wistar kyoto rats and spontaneously hypertensive rats: effects of antioxidant (honey) treatment. Int J Mol Sci 12(3):1888-1907.
Feryadi R, Sulastri D, Kadri H. 2014. Hubungan kadar profil lipid dengan kejadian hipertensi pada masyarakat etnik Minangkabau di kota Padang tahun 2012. J Kesehatan Andalas 3(2):206-211.
Fodor JG, Frohlich JJ, Genest JG, McPherson PR. 2000. Recommendations forthe management and treatment of dyslipidemia. CAMJ 162(10):1441-1447.
Gengatharan A, Dykes GA, Choo WS. 2015. Betalains: Natural plant pigments with potential application in functional foods. Food Sci Technol Int 64:645-649.
Guo M, Liu Y, Gao Y, Shi D. 2014. Chinese herbal medicine on dyslipidemia: progress and perspective. ECAM 2014 (ID 163036). doi:10.1155/2014/163036.
Helmizar, Jalal F, Liputo I. 2010. Antioksidan dalam masakan minang dan potensi protektif terhadap risiko penyakit kardiovaskular. JAKA 4(1):13-20.
Herrera M, Rodriguez O, Torregrosa L, Vasquez M, Blanco E, Calderon L. 2016. Traditional use of plants as antihypertensive in Jipijapa, Manab & Iacute; Comparison with the literature. In Proceedings of the MOL2NET. International Conference on Multidisciplinary Sciences. 25 December 2016-25 January 2017; Sciforum Electronic Conference Series 2. doi:10.3390/mol2net-02-03890.
Hsieh PC, Huang GJ, Ho YL, Lin YH, Huang SS. 2010. Activities of antioxidants. α-glukosidase inhibitors and aldose reductase inhibitors of the aqueous extracts of four Flemingia species in Taiwan. Botanical Studies 51:293-302.
Hu FB, Manson JE, Willet WC. 2001. Types of dietary fat and risk of coronary heart disease. J Am Coll Nutr 20(1):5-19.
[Kemenkes RI] Kementrian Kesehatan Republik Indonesia. 2014. Situasi Kesehatan Jantung. Jakarta: Pusat Data dan Informasi Kesehatan Jantung Kemenkes. Jakarta: Kemenkes.
Lukacinova A, Mojzis J, Benacka R, Keller J, Maguth T, Kurila P, Vasko L, RaczO, Nistiar F. 2008. Preventive effects of flavonoids on Alloxan-induced diabetes mellitus in rats. J Acta Vet Brno 77(2):175-182.
Nadernejad N, Ahmadimoghadam A, Hosseinifard J, Pourseyedi S. 2012. Phenylalanin ammonialyase activity, total phenolic and flavonoid content in flowers, leaves, hulls, and kernels of three pistachio (Pistaciavera L.) cultivars. American-Eurasian J Agric Environ Sci 12(6):807-814.
Roshan DP, Naveen KM, Manjul PS, Anita S, Naheed WS, Gulzar A, Sudarshan KS. 2010. Antioxidant potential of leaves of Plectranthus amboinicus (Lour) Spreng. Der Pharmacia Lettre 2(4):240-245.
Smeltzer CS. Bare GB. 2001. Buku Ajar Keperawatan Medikal Bedah edisi 8. Jakarta: EGC.
Sharma SB, Nasir A, Prabhu KM, Murthy PS, Dev G. 2003. Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of eugenia jambolana in alloxan induced diabetic rabbits. J Ethnopharmacol 85(2):201-206.
Shenoy S, Kumar H, Thashma, Nayak V, Prabhu K, Pai P. 2012. Hepatoprotective activity of Plectranthus amboinicus against Paracetamol induced hepatotoxicity in rats. Int J of Pharm Sci 1(2):32-38.
Suryowati T, Rimbawan, Damanik R, Bintang M, Handharyani E. 2015. Antihyperlipidemic activity of Torbangun extract (Coleusam boinicuslour) on diabetic rats induced by streptozotocin. IOSR J Pharm Biol Sci 5(1):50-64.
Suryowati T, Rimbawan, Damanik R, Bintang M, Handharyani E. 2015. Identifikasi komponen kimia dan aktivitas antioksidan dalam tanaman Torbangun (Coleus amboinicus Lour). J Gizi Pangan 10(3):217-224.
Syam FM, Lubis Z, Siregar MA. 2013. Gambaran asupan zat gizi, status gizi, dan produktivitas kerja pada pekerja pabrik kelapa sawit Bagerpang Estate PT. PP. LONSUM 2013. GKRE 2(5):1-9.
Viswanathaswamy AHM, Koti BC, Gore A, Thippeswamy AHM, Kulkarni RV. 2011. Antihyperglycemic and antihyperlipidemi activity of plactranthusamboinicus on normal and alloxanindiced diabetic rats. Indian J Pharm Sci 73(2):139-145.
[WHO] World Health Organization. 2014. Global Status Report on Noncommunicable Disease 2014. available on http://apps.who.int/iris/bitstream/10665/148114/1/9789241564854_eng.pdf?ua= (accessed 4th of November 2016).
Yadav JP, Sushila S, Kalia AN, Dangi AS. 2008. Hypoglycemic and hypolipidemic activity of ethanolic extract of Salvadora oleoides in normal and alloxan induced diabetic rats. Indian J Pharm Sci 40:23-27.
Authors
AmaliaN. R., DamanikM. R. M., & EkayantiI. (2018). Torbangun Leaves (Coleus amboinicus Lour) Powder Capsules Supplementation Improve Lipid Profile and Blood Pressure in Men with Hypercholesterol. Jurnal Gizi Dan Pangan, 13(2), 71-78. https://doi.org/10.25182/jgp.2018.13.2.71-78
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