The study aimed to analyze the correlation between Blood Glucose levels (BG) and Short-Term Memory scores (STM) among primary school children in Bogor, as controlled by Socioeconomic Status (SES), BMI-for-age (BAZ), Hemoglobin (Hb), folate, and vitamin B12 levels. It was a cross-sectional study applied for 915 students of the 4th–5th grades from 16 primary schools in the suburban area of the Cijeruk district. Morning blood samples were drawn from venous puncture of the inner arm. The specimens were then transported to laboratories to analyze the BG (hexokinase methods), Hb (non-cyanide Hb), as well as folate, and vitamin B12 using Liquid Chromatography and Mass Spectrometry. The STM was obtained through an object recall test performed by trained psychologists. The actual body weight and height were measured to determine BAZ. The characteristics of subjects and their SES were collected through interviews and structured questionnaires. Mann-Whitney and Chi-square tests were performed to compare differences between variables that were grouped by genders. Correlations between predictors and predicted variables were analyzed using simple logistic regression for the bivariates analysis and a binary logistic regression test for the multivariate analysis. There were significant differences in BAZ, BG, and STM between boys and girls (p<0.05). Most of the subject's BAZ was normal (85.2%). About 50.9% of subjects had normal Hb, 99.8% had folate deficiency, 47.8% had normal vitamin B12 level, and 54.9% had good STM score. There was no significant correlation between BAZ, Hb, folate, and vitamin B12 level with STM (p≥0.05), respectively. There was a significant positive correlation between BG and STM (p<0.05; OR=1.583; 95% CI:1.067−2.348) after being controlled by BAZ, subject’s characteristic, and SES. In conclusion, optimum blood glucose level improved the STM in primary school children. Therefore, provision of balanced diet, more especially breakfast, for school children is highly important.
Asperholm M, Hogman N, Rafi J, Herlitz A. 2019. What did you do yesterday? A meta-analysis of sex differences in episodic memory. Psychol Bull 145(8):785−821. https://doi.org/10.1037/bul0000197
Bozkaya IO, Yarali N, Kizilgün M, Ozkan S, Tunc B. 2017. Relationship between the levels of holotranscobalamin and vitamin B12 in children. Indian J Hematol Blood Transfus 33(4):537−540. https://doi.org/10.1007/s12288-017-0789-9
[BPS] Badan Pusat Statistik-Statisticts of Bogor Regency. 2019. Bogor Regency in Figure 2019. West Java (ID): BPS-Statisticts of Bogor Regency.
Brenhouse HC, Andersen SL. 2011. Developmental trajectories during adolescence in males and females: A cross-species understanding of underlying brain changes. Neurosci Biobehav Rev 35(8):1687−1703. https://doi.org/10.1016/j.neubiorev.2011.04.013
Burkhalter TM, Hillman CH. 2011. A narrative review of physical activity, nutrition, and obesity to cognition and scholastic performance across the human lifespan. Adv Nutr 2(2):201S−206S. https://doi.org/10.3945/an.111.000331
Gur RC, Gur RE. 2017. Complementarity of sex differences in brain and behaviour: From laterality to multimodal neuroimaging. J Neurosci Res 95(1−2):189−199. https://doi.org/10.1002/jnr.23830
Haile D, Nigatu D, Gashaw K, Demelash H. 2016. Height for age z score and cognitive function are associated with academic performance among school children aged 8−11 years old. Arch Public Health 74(1):1−7. https://doi.org/10.1186/s13690-016-0129-9
Hosmer Jr DW, Lemeshow S, Sturdivant RX. 2013. Applied Logistic Regression, 3rd ed. New York (USA): John Wiley & Sons.
Ibda F. 2015. Perkembangan kognitif: Teori jean piaget. Intelektualita 3(1):27−38.
Khan KM, Jialal I. 2021. Folic Acid Deficiency. In: StatPearls. Treasure Island (USA): StatPearls Publishing.
Kustiyah L, Syarief H, Hardinsyah, Rimbawan, Suradijono SHR. 2005. Kajian pengaruh intervensi makanan kudapan terhadap peningkatan kadar glukosa darah dan daya ingat siswa sekolah dasar. [Dissertation]. Bogor (ID): IPB University.
Kvestad I, Taneja S, Upadhyay RP, Hysing M, Bhandari N, Strand TA. 2020. Vitamin B12, folate, and cognition in 6- to 9-Year-Olds: A randomized controlled trial. Pediatrics 145(3):e20192316. https://doi.org/10.1542/peds.2019-2316
LaMorte WW, Sullivan L. 2021. Confounding and effect measure modification. Epidemiology and biostatistics. https://sphweb.bumc.bu.edu/otlt/mph-modules/bs/bs704-ep713_confounding-em/bs704-ep713_confounding-em_print.html [Accessed 26th November 2021].
Lipina JL, Segretin MS. 2015. Strengths and weakness of neuroscientific investigations of childhood poverty: Future directions. Front Hum Neurosci 9(53):1−11. https://doi.org/10.3389/fnhum.2015.00053
Lubis Z, Hardinsyah, Syarief H, Jalal F, Muhilal. 2008. Pengaruh pemberian suplemen vitamin B12 terhadap vitamin B12 serum, hemoglobin, dan daya ingat anak prasekolah. [Dissertation]. Bogor (ID): IPB University.
Nimgampalle M, Chakravarthy H, Devanathan V. 2021. Chapter 8 - Glucose metabolism in the brain: An update. Recent Developments in Applied Microbiology and Biochemistry 2:77−88. https://doi.org/10.1016/B978-0-12-821406-0.00008-4
Ong LC, Chandran V, Lim YY, Chen AH, Poh BK. 2010. Factors associated with poor academic achievement among urban primary school children in Malaysia. Singapore Med J 51(3):247−252.
Piccolo LDR, Arteche AX, Fonseca RP, Grassi-Oliveira R, Salles JF. 2016. Influence of family socioeconomic status on IQ, language, memory and executive functions of Brazilian children. Psicol: Reflex Crit 29(1). https://doi.org/10.1186/s41155-016-0016-x
Podila SK. 2019. Concentration, memory and gender-a case study on high school students. International Journal of Scientific Research in Science and Technology 6(2):756−760. https://doi.org/10.32628/IJSRST1962161
Rauh-Pfeiffer A, Handel U, Demmelmair H, Peissner W, Niesser M, Moretti D, Martens V, Wiseman S, Weichert J, Heene M et al. 2014. Three-month B vitamin supplementation in pre-school children affects folate status and homocysteine, but not cognitive performance. Eur J Nutr 53(7):1445−1456. https://doi.org/10.1007/s00394-013-0647-y
Roalf DR, Gur RE, Ruparel K, Calkins ME, Satterthwaite TD, Bilker WB, Hakonarson H, Harris LJ, Gur RC. 2014. Within-individual variability in neurocognitive performance: Age- and sex-related differences in children and youths from ages 8 to 21. Neuropsychology 28(4):506−518. https://doi.org/10.1037/neu0000067
Robinson EB, Kirby A, Ruparel K, Yang J, McGrath L, Anttila V, Neale BM, Merikangas K, Lehner T, Sleiman PM et al. 2015. The genetic architecture of pediatric cognitive abilities in the Philadelphia Neurodevelopmental Cohort. Mol Psychiatry 20:454-458. https://doi.org/10.1038/mp.2014.65
Schneider ALC, Jonassaint C, Sharrett AR, Mosley TH, Astor BC, Selvin E, Coresh J, Gottesman RF. 2015. Hemoglobin, anemia, and cognitive function: The atherosclerosis risk in communities study. J Gerontol A Biol Sci Med Sci 71(6): 772−779. https://doi.org/10.1093/gerona/glv158
Shaffer DR, Kipp K. 2013. Developmental Psychology: Childhood and Adolescence. Belmont (USA): Wadsworth, Cengage Learning.
Slotnick SD. 2017. Cognitive Neuroscience of Memory. Cambridge (UK): Cambridge University Press.
Smith MA, Riby LM, van Eekelen JAM, Foster JK. 2011. Glucose enhancement of human memory: A comprehensive research review of the glucose memory facilitation effect. Neurosci Biobehav Rev 35(3): 770−783. https://doi.org/10.1016/j.neubiorev.2010.09.008
Spets DS, Slotnick SD. 2019. Similar patterns of cortical activity in females and males during item memory. Brain Cogn 35:p.103581. https://doi.org/10.1016/j.bandc.2019.103581
Sunehag AL, Haymond MW. 2004. Hypoglycemia in infants and children. In Pediatric Endocrinology: Mechanisms, Manifestations, and Management. Philadelphia (USA): Lippincott Williams & Wilkins
Sünram-Lea SI, Owen L. 2017. The impact of diet-based glycaemic response and glucose regulation on cognition: Evidence across the lifespan Proc Nutr Soc 76(4):466−477. https://doi.org/10.1017/S0029665117000829
Tang Z, Zhang N, Liu A, Luan D, Zhao Y, Song C, Ma G. 2017. The effects of breakfast on short-term cognitive function among Chinese white-collar workers: protocol for a three-phase crossover study. BMC Public Health 17(1):1−8. https://doi.org/10.1186/s12889-017-4017-1
Van De Rest O, van Hooijdonk LW, Doets E, Schiepers OJ, Eilander A, De Groot LC. 2012. B Vitamins and n-3 fatty acids for brain development and function: Review of human studies. Ann Nutr Metab 60(4):272−292. https://doi.org/10.1159/000337945
Van der Zwaluw NL, Dhonukshe-Rutten RA, van Wijngaarden JP, Brouwer-Brolsma EM, van de Rest O, In't Veld PH, Enneman AW, van Dijk SC, Ham AC, Swart KM et al. 2014. Results of 2-year vitamin B treatment on cognitive performance: Secondary data from an RCT. Neurology 83(23):2158−2166. https://doi.org/10.1212/WNL.0000000000001050
Veldwijk J, Scholtens S, Hornstra G, Bemelmans WJ. 2011. Body mass index and cognitive ability of young children. Obes Facts 4(4):264−269. https://doi.org/10.1159/000331015
[WHO] World Health Organization, 2011. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity (No. WHO/NMH/NHD/MNM/11.1). Geneva (CH): World Health Organization.