Golden Berry (Physalis peruviana) Juice for Reduction of Blood Glucose and Amelioration of Insulin Resistance in Diabetic Rats

  • Larasati Sekar Kinasih Nutrition Science Study Program, Faculty of Medicine, Diponegoro University, Semarang 50244, Indonesia
  • Kis Djamiatun Biomedical Science Department, Faculty of Medicine, Diponegoro University, Semarang 50244, Indonesia
  • Ahmad Ni’matullah Al-Baarri Food Technology Department, Faculty of Animal and Agricultural Science, Diponegoro University, Semarang 50244, Indonesia http://orcid.org/0000-0002-1459-7069
Keywords: blood glucose, golden berry juice, insulin resistance, type-2 diabetes mellitus

Abstract

The study aimed to gather evidence on the potential of golden berry (GB) juice in improving blood glucose level, insulin level, and insulin resistance in type-2 diabetes mellitus (T2DM) in comparison to quercetin supplement in animal model. This study used true experimental pre-post-test study with control group design. Twenty five Wistar male rats were divided into five groups: healthy group (K-), T2DM positive control group (K+), T2DM group with 1 ml/200 g BW/day of GB juice (X1), T2DM group with 5 ml/200 g BW/day of GB juice (X2), and T2DM group with 6 mg/200 g BW/day of quercetin (X3). The T2DM rasts were obtained from healthy rats induced by high-fat feed and Streptozotocin (STZ). The result showed that various dosages of GB juice (X1 and X2) were able to lower blood glucose level (-79.15; -110.44; -108.20) and HOMA-IR (-2.40; -2.92; -3.02). In addition, it was also able to increase insulin level (0.26; 1.99; 1.42) compared to (K+) group (p<0.05). In conclusion, GB juice was able to lower blood glucose level, insulin resistance, and increase insulin level in T2DM rats. The GB juice dosage of 1 ml/200 g BW/day and 5 ml/200 g BW/day were better in lowering the blood glucose level and improving insulin resistance compared to quercetin supplement.

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Published
2020-03-28
How to Cite
Kinasih, L. S., Djamiatun, K., & Al-Baarri, A. N. (2020). Golden Berry (Physalis peruviana) Juice for Reduction of Blood Glucose and Amelioration of Insulin Resistance in Diabetic Rats. Jurnal Gizi Dan Pangan, 15(1), 37-44. https://doi.org/10.25182/jgp.2020.15.1.37-44
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Articles