Golden Berry (Physalis peruviana) Juice for Reduction of Blood Glucose and Amelioration of Insulin Resistance in Diabetic Rats
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Issue
Vol. 15 No. 1 (2020)
Published
28 March 2020
Keywords:
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blood glucose, golden berry juice, insulin resistance, type-2 diabetes mellitus
Abstract
The study aimed to gather evidence on the potential of golden berry (GB) juice in improving blood glucose level, insulin level, and insulin resistance in type-2 diabetes mellitus (T2DM) in comparison to quercetin supplement in animal model. This study used true experimental pre-post-test study with control group design. Twenty five Wistar male rats were divided into five groups: healthy group (K-), T2DM positive control group (K+), T2DM group with 1 ml/200 g BW/day of GB juice (X1), T2DM group with 5 ml/200 g BW/day of GB juice (X2), and T2DM group with 6 mg/200 g BW/day of quercetin (X3). The T2DM rasts were obtained from healthy rats induced by high-fat feed and Streptozotocin (STZ). The result showed that various dosages of GB juice (X1 and X2) were able to lower blood glucose level (-79.15; -110.44; -108.20) and HOMA-IR (-2.40; -2.92; -3.02). In addition, it was also able to increase insulin level (0.26; 1.99; 1.42) compared to (K+) group (p<0.05). In conclusion, GB juice was able to lower blood glucose level, insulin resistance, and increase insulin level in T2DM rats. The GB juice dosage of 1 ml/200 g BW/day and 5 ml/200 g BW/day were better in lowering the blood glucose level and improving insulin resistance compared to quercetin supplement.
References
Alkhalidy H, Moore W, Zhang Y, McMillan R, Wang A, Ali M, Suh KS, Zhen W, Cheng Z, Jia Z et al. 2015. Small molecule kaempferol promotes insulin sensitivity and preserved pancreatic β-cell mass in middle-aged obese diabetic mice. J Diabetes Res 20015:1–14. http://dx.doi.org/10.1155/2015/532984.
Al-numair KS, Chandramohan G, Veeramani C, Alsaif MA. 2015. Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats. Redox Rep 20(5):198–209. https://doi.org/10.1179/1351000214Y.0000000117.
Anhe FF, Desjardins Y, Pilon G, Dudonne S, Genovese MI, Lajolo FM, Marette A. 2013. Polyphenols and type 2 diabetes : A prospective review. Pharma Nutrition 1(4):105–114. http://dx.doi.org/10.1016/j.phanu.201307.004.
Anjani PP, Damayanthi E, Rimbawan R, Handharyani, E. 2018. Potential of okra (Abelmoschus esculentus L.) extract to reduce blood glucose and malondialdehyde (MDA) liver in streptozotocin-induced diabetic rats. J Gizi Pangan 13(1):47–54. http://dx.doi.org/10.25182/jgp.2018.13.1.47-54.
Antony PJ, Gandhi GR, Stanlin A, Balakrishna K, Toppo E, Sivasankaran K, Ignacimuthu S, Al-Dhabi NA. 2017. Myoinositol ameliorates high-fat diet and streptozotocin-induced diabetes in rats through promoting insulin receptor signaling. Biomed Pharmacother 88:1098–1113. https://doi.org/10.1016/j.biopha.2017.01.170
Chikezie PC, Ojiako OA, Ogbuji AC. 2015. Oxidative stress in diabetes mellitus. Int J Biol Chem 9(3):92–109. doi: 10.3923/ijbc.2015.92.109.
Chis IC, Coseriu A, Simedrea R, Orors A, Nagy AL, Clichici S. 2015. In vivo effects of quercetin in association with moderate exercise training in improving streptozotocin-induced aortic tissue injuries. Molecules 20(12):21770–2178. https://doi.org/10.3390/molecules201219802.
Choi H, Jeong SM, Huh GH, Kim JI. 2015. Quercetin ameliorates insulin sensitivity and liver steatosis partly by increasing adiponectin expression in ob/ob mice. Food Sci Biotechnol 24(1):273–279. https://doi.org/10.1007/s10068-015-0036-9.
Esteghamati A, Ashraf H, Khalilzadeh O, Zandieh A, Nakhjavani M, Rashidi A, Haghazali M, Asgari F. 2010. Optimal cut-off of homeostasis model assessment of insulin resistance (HOMA-IR) for the diagnosis of metabolic syndrome : Third national surveillance of risk factors of non- communicable diseases in Iran (SuRFNCD-2007). Nutr Metab 7(26):1–8.
https://doi.org/10.1186/1743-7075-7-26.
Garcia-bailo B, El-Sohemy A, Badawi A. 2011. Vitamins D, C, and E in the prevention of type 2 diabetes mellitus: Modulation of inflammation and oxidative stress. Biologics 2011(5):7–19. doi:10.2147/BTT.S14417.
Ghasemi A, Khalfi S, Jedi S. 2014. Streptozotocin-nicotinamide-induced rat model of type 2 diabetes. Hung Acta Physiol 101(4):408–420. https://doi.org/10.1556/APhysiol.101.2014.4.2
Gheibi S, Kashfi K, Ghasemi A. 2017. A practical guide for induction of type-2 diabetes in rat: Incorporating a high-fat diet and streptozotocin. Biomed Pharmacother 95:605–613. http://dx.doi.org/10.1016/j.biopha.2017.08.098.
Hassan AI, Ghoneim MAM. 2013. A possible inhibitory effect of physalis (Physalis pubescens L.) on diabetes in male rats. World Appl Sci J 21(5):681–688. doi:10.5829/idosi.wasj.2013.21.5.7220.
[IDF] International Diabetes Federation, 2017. IDF Diabetes Atlas. https://www.idf.org/e-library/epidemiology-research/diabetes-atlas/134-idf-diabetes-atlas-8th-edition.html [Accessed 17th March 2018].
Kahn SE, Cooper ME, Prato SD. 2014. Pathophysiology and treatment of type 2 diabetes: Perspectives on the past, present and future. The Lancet 383(9922):1068–1083. https://doi.org/10.1016/S0140-6736(13)62154-6.
Larson AJ, Symons JD, Jalili T. 2012. Therapeutic potential of quercetin to decrease blood pressure: Review of Efficacy and mechanisms. American Society for Nutrition Adv Nutr 3(1):39–46. https://doi.org/10.3945/an.111.001271
Luo C, Yang H, Tang C, Yao G, Kong L, He H, Zhou Y. 2015. Kaempferol alleviates insulin resistance via hepatic IKK / NF- κB signal in type 2 diabetic rats. Int Immunopharmacol 28(1):744–750. http://dx.doi.org/10.1016/j.intimp.2015.07.018.
Puente LA, Pinto-Munoz CA, Castro ES, Cortes M. 2011. Physalis peruviana Linnaeus, the multiple properties of a highly functional fruit: A review. Food Rres Int 44(7):1733–1740. http://dx.doi.org/10.1016/j.foodres.2010.09.034.
Qatanani M, Lazar MA. 2007. Mechanisms of obesity-associated insulin resistance: Many choices on the menu. Genes Dev 21(12):1443–1455. doi:10.1101/gad.1550907.
Ramadan MF, Moersel JT. 2006. Impact of enzymatic treatment on chemical composition, physicochemical properties and radical scavenging activity of goldenberry (Physalis peruviana L.) juice. J Sci Food Agric 87(3):452–460. doi:10.1002/jsfa.2728.
Sah SP, Singh B, Choudhary S, Kumar A . 2016. Animal models of insulin resistance: A review. Pharmacol Rep 68(6):1165–1177. https://doi.org/10.1016/j.pharep.2016.07.010.
Sathyadevi M, Suchithra ER, Subramanian S. 2014. Physalis peruviana Linn. fruit extract improves insulin sensitivity and ameliorates hyperglycemia in high-fat diet low dose STZ-induced type 2 diabetic rats. J Pharm Res 8(4):625–632.
[WHO] World Health Organization. 2000. General guidelines for methodologies on research and evaluation of traditional medicine. World Health Organization Geneva. http://apps.who.int/iris/bitstream/10665/66783/1/WHO_EDM_TRM_2000.1.pdf [Accessed 24th November 2017].
Zuloaga KL, Krasnow SM, Zhu X, Zhang W, Jouihan SA, Shangraw RE, Alkayed NJ, Marks DL. 2014. Mecha-nism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke. Plos One 9(5):1-9. https://doi.org/10.1371/journal.pone.0097529.
Al-numair KS, Chandramohan G, Veeramani C, Alsaif MA. 2015. Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats. Redox Rep 20(5):198–209. https://doi.org/10.1179/1351000214Y.0000000117.
Anhe FF, Desjardins Y, Pilon G, Dudonne S, Genovese MI, Lajolo FM, Marette A. 2013. Polyphenols and type 2 diabetes : A prospective review. Pharma Nutrition 1(4):105–114. http://dx.doi.org/10.1016/j.phanu.201307.004.
Anjani PP, Damayanthi E, Rimbawan R, Handharyani, E. 2018. Potential of okra (Abelmoschus esculentus L.) extract to reduce blood glucose and malondialdehyde (MDA) liver in streptozotocin-induced diabetic rats. J Gizi Pangan 13(1):47–54. http://dx.doi.org/10.25182/jgp.2018.13.1.47-54.
Antony PJ, Gandhi GR, Stanlin A, Balakrishna K, Toppo E, Sivasankaran K, Ignacimuthu S, Al-Dhabi NA. 2017. Myoinositol ameliorates high-fat diet and streptozotocin-induced diabetes in rats through promoting insulin receptor signaling. Biomed Pharmacother 88:1098–1113. https://doi.org/10.1016/j.biopha.2017.01.170
Chikezie PC, Ojiako OA, Ogbuji AC. 2015. Oxidative stress in diabetes mellitus. Int J Biol Chem 9(3):92–109. doi: 10.3923/ijbc.2015.92.109.
Chis IC, Coseriu A, Simedrea R, Orors A, Nagy AL, Clichici S. 2015. In vivo effects of quercetin in association with moderate exercise training in improving streptozotocin-induced aortic tissue injuries. Molecules 20(12):21770–2178. https://doi.org/10.3390/molecules201219802.
Choi H, Jeong SM, Huh GH, Kim JI. 2015. Quercetin ameliorates insulin sensitivity and liver steatosis partly by increasing adiponectin expression in ob/ob mice. Food Sci Biotechnol 24(1):273–279. https://doi.org/10.1007/s10068-015-0036-9.
Esteghamati A, Ashraf H, Khalilzadeh O, Zandieh A, Nakhjavani M, Rashidi A, Haghazali M, Asgari F. 2010. Optimal cut-off of homeostasis model assessment of insulin resistance (HOMA-IR) for the diagnosis of metabolic syndrome : Third national surveillance of risk factors of non- communicable diseases in Iran (SuRFNCD-2007). Nutr Metab 7(26):1–8.
https://doi.org/10.1186/1743-7075-7-26.
Garcia-bailo B, El-Sohemy A, Badawi A. 2011. Vitamins D, C, and E in the prevention of type 2 diabetes mellitus: Modulation of inflammation and oxidative stress. Biologics 2011(5):7–19. doi:10.2147/BTT.S14417.
Ghasemi A, Khalfi S, Jedi S. 2014. Streptozotocin-nicotinamide-induced rat model of type 2 diabetes. Hung Acta Physiol 101(4):408–420. https://doi.org/10.1556/APhysiol.101.2014.4.2
Gheibi S, Kashfi K, Ghasemi A. 2017. A practical guide for induction of type-2 diabetes in rat: Incorporating a high-fat diet and streptozotocin. Biomed Pharmacother 95:605–613. http://dx.doi.org/10.1016/j.biopha.2017.08.098.
Hassan AI, Ghoneim MAM. 2013. A possible inhibitory effect of physalis (Physalis pubescens L.) on diabetes in male rats. World Appl Sci J 21(5):681–688. doi:10.5829/idosi.wasj.2013.21.5.7220.
[IDF] International Diabetes Federation, 2017. IDF Diabetes Atlas. https://www.idf.org/e-library/epidemiology-research/diabetes-atlas/134-idf-diabetes-atlas-8th-edition.html [Accessed 17th March 2018].
Kahn SE, Cooper ME, Prato SD. 2014. Pathophysiology and treatment of type 2 diabetes: Perspectives on the past, present and future. The Lancet 383(9922):1068–1083. https://doi.org/10.1016/S0140-6736(13)62154-6.
Larson AJ, Symons JD, Jalili T. 2012. Therapeutic potential of quercetin to decrease blood pressure: Review of Efficacy and mechanisms. American Society for Nutrition Adv Nutr 3(1):39–46. https://doi.org/10.3945/an.111.001271
Luo C, Yang H, Tang C, Yao G, Kong L, He H, Zhou Y. 2015. Kaempferol alleviates insulin resistance via hepatic IKK / NF- κB signal in type 2 diabetic rats. Int Immunopharmacol 28(1):744–750. http://dx.doi.org/10.1016/j.intimp.2015.07.018.
Puente LA, Pinto-Munoz CA, Castro ES, Cortes M. 2011. Physalis peruviana Linnaeus, the multiple properties of a highly functional fruit: A review. Food Rres Int 44(7):1733–1740. http://dx.doi.org/10.1016/j.foodres.2010.09.034.
Qatanani M, Lazar MA. 2007. Mechanisms of obesity-associated insulin resistance: Many choices on the menu. Genes Dev 21(12):1443–1455. doi:10.1101/gad.1550907.
Ramadan MF, Moersel JT. 2006. Impact of enzymatic treatment on chemical composition, physicochemical properties and radical scavenging activity of goldenberry (Physalis peruviana L.) juice. J Sci Food Agric 87(3):452–460. doi:10.1002/jsfa.2728.
Sah SP, Singh B, Choudhary S, Kumar A . 2016. Animal models of insulin resistance: A review. Pharmacol Rep 68(6):1165–1177. https://doi.org/10.1016/j.pharep.2016.07.010.
Sathyadevi M, Suchithra ER, Subramanian S. 2014. Physalis peruviana Linn. fruit extract improves insulin sensitivity and ameliorates hyperglycemia in high-fat diet low dose STZ-induced type 2 diabetic rats. J Pharm Res 8(4):625–632.
[WHO] World Health Organization. 2000. General guidelines for methodologies on research and evaluation of traditional medicine. World Health Organization Geneva. http://apps.who.int/iris/bitstream/10665/66783/1/WHO_EDM_TRM_2000.1.pdf [Accessed 24th November 2017].
Zuloaga KL, Krasnow SM, Zhu X, Zhang W, Jouihan SA, Shangraw RE, Alkayed NJ, Marks DL. 2014. Mecha-nism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke. Plos One 9(5):1-9. https://doi.org/10.1371/journal.pone.0097529.
Authors
KinasihL. S., DjamiatunK., & Al-BaarriA. N. (2020). Golden Berry (Physalis peruviana) Juice for Reduction of Blood Glucose and Amelioration of Insulin Resistance in Diabetic Rats. Jurnal Gizi Dan Pangan, 15(1), 37-44. https://doi.org/10.25182/jgp.2020.15.1.37-44
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