Potential of okra (Abelmoschus esculentus L.) extract to reduce blood glucose and malondialdehyde (MDA) liver in streptozotocin-induced diabetic rats

  • Putri Puncak Anjani Department of Food and Science Technology, Brawijaya University, Malang 65145, Indonesia
  • Evy Damayanthi Department of Community Nutrition, Faculty of Human Ecology, Bogor Agricultural University, Bogor 16680, Indonesia
  • Rimbawan Rimbawan Department of Community Nutrition, Faculty of Human Ecology, Bogor Agricultural University, Bogor 16680, Indonesia
  • Ekowati Handharyani Department of Veterinary Clinic Reproduction and Pathology, Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor 16680, Indonesia
Keywords: blood glucose, diabetic rats, malondialdehyde, okra extract, streptozotocin

Abstract

The study aimed to analyze the potential of okra to reduction blood glucose and MDA liver in streptozotocin (STZ)-induced diabetic rats. Design experiment used in this study was pre and post test controlled group design. The first step of this study was analyzed bioactive compound of okra extract. The next step was administired orally of okra extract to control and diabetic rats induced by streptozotocin 50 mg/kgBW for 14 days. Sprague dawley rats were divided into six groups: normal control (N), diabetic control (DM), diabetic treated with green okra extract (GOE) with the dosage of 5 mg/kgBW quercetin and 10 mg/kgBW quercetin, diabetes treated with purple okra extract (POE) with the dosage of 5 mg/kgBW quercetin and 10 mg/kgBW quercetin. Blood glucose were measured each five days and malondialdehyde (MDA) liver in rats were measured in the end of intervention. The following results show that phenolic and quercetin of purple okra extract were higher (3.60%; 0.45 mg/g) than green okra extract (3.58%; 0.27 mg/g). Administration of GOE I, GOE II, POE I and POE II in diabetic rats showed significant (P<0.05) reduction in blood glucose level (115.25 mg/dl; 86 mg/dl; 180.75 mg/dl; 91 mg/dl) and improve level of MDA. These results suggest that intervention of okra extract based on quercetin compound show an antihyperglicemic potential and improve MDA level.

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Author Biography

Putri Puncak Anjani, Department of Food and Science Technology, Brawijaya University, Malang 65145, Indonesia
Putri Puncak Anjani
I151150011
Postgraduate Student of Community NutritionBogor agricultural University
Published
2018-03-28
How to Cite
Anjani, P. P., Damayanthi, E., Rimbawan, R., & Handharyani, E. (2018). Potential of okra (Abelmoschus esculentus L.) extract to reduce blood glucose and malondialdehyde (MDA) liver in streptozotocin-induced diabetic rats. Jurnal Gizi Dan Pangan, 13(1), 47-54. https://doi.org/10.25182/jgp.2018.13.1.47-54
Section
Articles