Effects of Leadtree Seed (Leucaena leucocephala) Extract in Inhibiting the Increase of Postprandial Blood Glucose Level in Alloxan-induced Diabetic Rats

  • Ibnu Wadud Pujangga Bachelor Study Program of Medical Science, UPN Veteran Jakarta, Jakarta 12450, Indonesia
  • Dorlina Nainggolan Department of Pharmacology, Faculty of Medicine, UPN Veteran Jakarta, Jakarta 12450, Indonesia
  • Maria Selvester Thadeus Department of Anatomical Pathology, Faculty of Medicine, UPN Veteran Jakarta, Jakarta 12450, Indonesia
Keywords: diabetes mellitus, two hour postprandial blood glucose level, white leadtree seed extract

Abstract

This research aimed to add evidence on the effect of white leadtree seed extract (Leucaena leucocephala) on postprandial blood glucose level on white male alloxan induced diabetic rats. This research was an experiment with pretest-posttest control group design. The subjects of this research were 25 white male rats, Wistar strain was divided into 5 groups. Group I was the positive control, which was treated with Acarbose, group II was the negative control, and group III, group IV, and group V were treatment groups and were given white leadtree seed extract of 1.5 g/kg of BW, 3.5 g/kg of BW, and 7.8 g/kg of BW respectively. Blood glucose level was checked before and two hours after treatment. The statistical analysis used one-way ANOVA and Bonferroni post hoc test. The result showed that there were no significant differences between group III, group IV, and group V and the positive control group (p<0.05). The best result of inhibition of the increase in blood glucose level was found in 7.8 g/kg of BW (group V) dosage group with average difference of 186.4 mg/dl. In conclusion, white leadtree seed extract could decrease two hour postprandial blood glucose level in white male alloxan-induced diabetic rats and a dosage of 7.8 g/kg of BW was shown to be the most effective.

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Author Biography

Ibnu Wadud Pujangga, Bachelor Study Program of Medical Science, UPN Veteran Jakarta, Jakarta 12450, Indonesia
Fakultas Kedokteran UPNVJ
Published
2019-11-26
How to Cite
Pujangga, I. W., Nainggolan, D., & Thadeus, M. S. (2019). Effects of Leadtree Seed (Leucaena leucocephala) Extract in Inhibiting the Increase of Postprandial Blood Glucose Level in Alloxan-induced Diabetic Rats. Jurnal Gizi Dan Pangan, 14(3), 157-164. https://doi.org/10.25182/jgp.2019.14.3.157-164
Section
Articles