Effects of Leadtree Seed (Leucaena leucocephala) Extract in Inhibiting the Increase of Postprandial Blood Glucose Level in Alloxan-induced Diabetic Rats
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Issue
Vol. 14 No. 3 (2019)
Accepted
26 November 2019
Published
26 November 2019
Keywords:
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diabetes mellitus, two hour postprandial blood glucose level, white leadtree seed extract
Abstract
This research aimed to add evidence on the effect of white leadtree seed extract (Leucaena leucocephala) on postprandial blood glucose level on white male alloxan induced diabetic rats. This research was an experiment with pretest-posttest control group design. The subjects of this research were 25 white male rats, Wistar strain was divided into 5 groups. Group I was the positive control, which was treated with Acarbose, group II was the negative control, and group III, group IV, and group V were treatment groups and were given white leadtree seed extract of 1.5 g/kg of BW, 3.5 g/kg of BW, and 7.8 g/kg of BW respectively. Blood glucose level was checked before and two hours after treatment. The statistical analysis used one-way ANOVA and Bonferroni post hoc test. The result showed that there were no significant differences between group III, group IV, and group V and the positive control group (p<0.05). The best result of inhibition of the increase in blood glucose level was found in 7.8 g/kg of BW (group V) dosage group with average difference of 186.4 mg/dl. In conclusion, white leadtree seed extract could decrease two hour postprandial blood glucose level in white male alloxan-induced diabetic rats and a dosage of 7.8 g/kg of BW was shown to be the most effective.
References
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Nugraha DR, Yusuf AL. 2015. Efek antihiperglikemik ekstrak etanol dan ekstrak heksan biji petai cina (Leucaena glauca, Benth) pada tikus putih jantan diabetes yang diinduksi aloksan 2(1):1–10. https://docplayer.info/44924250-Efek-antihiperglikemikektsrak-etanol-dan-ekstrak-heksan-biji-petai-cina.html.
Parmawati RRPI. 2014. Efek ekstrak etanol pohon ciplukan (Physalis angulata L) terhadap penurunan konsentrasi gula darah tikus jantan galur wistar yang diinduksi dengan aloksan tetrahidrat [Skripsi]. Jakarta: Universitas Pembangunan Nasional Veteran Jakarta.
Seino Y, Fukushima M, Yabe D. 2010. GIP and GLP-1 the two incretin hormones: similarities and differences. J Diabetes Investig 1(1–2):8–23.
Shofiyullah M. 2015. Identifikasisenyawa aktif dan uji potensi antimalaria ekstrak etanol 80% batang widuri (Calotropis gigantea) pada hewan coba yang terinfeksi Plasmodium berghei [Undegraduate Prosiding] Penelitian Sivitas AkademikaUnisba (Kesehatan) (page 955–961), Gelombang 2 Tahun Akademik 2014-2015. Bandung: Universitas Islam Bandung.
Silvita SD, Sastramihardja SH, Rukanta D. 2015. Efek Pemberian Infusa Biji Petai China (Leucaena leucocephala) dalam Menurunkan Konsentrasi Glukosa Darah Puasa Pada Mencit Model Diabet
Suryanti AP, Artawan IK, Martriani NAT. 2016. Potensi Ektrak Kasar Biji Lamtoro Gung (Leucaena leucocephala) Untuk Menurunkan Glukosa Darah Tikus Putih. Prosiding Seminar Nasional MIPA 2016 (page 287–295), 30th July Bali: FMIPA Undiksha.
Utami M, Wowor MP, Mambo C. 2015. Uji efek pemberian ekstrak biji petai cina(Leucaena leucocephala L) terhadapkonsentrasi gula darah tikus wistar (Rattus norvegicus) yang diinduksialoksan. Jurnal e-Biomedik 3(1):363–367.
Willihnganz C. 2013. Basic Pharmacology for Nurses. Sixteen Edition. Canada: Elsevier.
[WHO] World Health Organization. 2016. Diabetes. http://www.who.int/mediacentrefactsheets/fs312/en/ [Acessed 18 Septem-ber 2016].
Yuriska A. 2009. Efek aloksan terhadap konsentrasi glukosa darah tikus wistar [Undergraduated Thesis]. Semarang: Universitas Diponegoro. Thesis]. Malang: UIN Maulana Malik Ibrahim.
Aravind SR, Saboo B, Sadikot S, Shah SN, Makkar BM, Kalra S, Kannampilly J, Kesavadev J, Ghoshal S, Zargar AH, et al. 2015. Consensus statement on management of post-prandial hyperglycemia in clinical practice in India. J Assoc Physicians India 63:45–58.
[Balitbangkes] Badan Penelitian dan Pengembangan Kesehatan. 2013. Riset Kesehatan Dasar. Jakarta: Kemenkes RI.
Ceriello A. 2005. Perspectives in diabetes postprandial hyperglycemia and diabetes complications: Is it time to treat?. Diabetes 54(1):1–7. https://doi.org/10.2337/diabetes.54.1.1
Ceriello A, Davidson J, Hanefeld M, Leiter L, Monnier L, Owens D, Tajima N, Tuomilehto J. 2006. Postprandial hyperglycaemia and cardiovascular complica-tions of diabetes: An update. Nutr Metab Cardiovasc Dis 16(7):453–456. doi.org/10.1016/j.numecd.2006.05.006.
Chahyono TB, Maulani A, Ridwan M, Syarifah AN, Adekayanti A, Widada H. 2012. Antidiabetic Drug Ethyl Acetate Fraction of Leucaena Leucocephala Seed Extract In Wistar Aloxan Induced. International Conference: Research and Application on Traditional Complementary and Alternative Medicine in Health Care (TCAM) (page 181–186), 22-23 June. Surakarta: Indonesia.
[Depkes RI] Departemen Kesehatan Republik Indonesia. 2013. Diabetes mellitus penyebab kematian nomor 6 di dunia: Kemenkes tawarkan solusi cerdik melalui posbindu. Departemen Kesehatan Republik Indonesia. http://www.depkes.go.id/article/view/2383/diabetes-melitus-penyebab-kematian-nomor-6-di-dunia-kemenkes-tawarkan-solusi-cerdik-melalui-posbindu.html [Acessed 9 May 2017]
Derosa G, Maffioli P. 2012. α-glucosidase inhibitors and their use in clinical practice. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506243/ [Acessed 7 March 2017].
Dijk JWV, Manders RJF, Hartgens F, Stehouwer CD, Praet SFE, Loon LJCV. 2011. Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients. Diabetes Res Clin Pract 93(1):31–37. https://doi.org/10.1016/j.diabres.2011.03.021
Efendi R, Damayanthi E, Kustiyah L, Kusomorini N. 2010. Pengendalian kadar glukosa darah oleh teh hijau dan atau teh daun murbei pada tikus diabetes. J Gizi Pangan 5(2):87–94.
Febrian T. 2017. Uji Efektivitas Kulit Buah Naga Merah (Hylocereus polyrhizus) untuk Menghambat Pembentukan Asam Urat pada Tikus Putih Jantan Galur Sprague-Dawley yang Diinduksi Kafein [undergraduate thesis]. Jakarta: Universitas Pembangunan Nasional Veteran Jakarta.
Fonseca V. 2003. Clinical significance of targeting postprandial and fasting hyperglycemia in managing type 2 diabetes mellitus. Curr Med Res Opin19(7):635–631.
[IDF] International Diabetes Federation. 2011. Diabetes Atlas. 5th Ed. Brussels (BE): International Diabetes Federation.
Jasaputra DK, Rahardja F, Christian E. 2014. Efek jus gel lidah buaya (Aloe vera L.) dalam menghambat penyerapan glukosa di saluran cerna pada manusia. Global Medical and Health Communication 2(1):1–5.
Kuppusamy UR, Arumugam B, Azaman N, Chai JW. 2014. Leucaena leucocephala fruit aqueous extract stimulates adipogenesis, lipolysis, and glucose uptake in primary rat adipocytes. Scientific World Journal 2014:1–8. http://dx.doi.org/10.1155/2014/737263
Kristanto H, Santoso MCKP. 2015. Prarencana pabrik na-cmc berbahan baku kulit singkong kapasitas na-cmc 5.921 ton/tahun [Undergraduate Thesis]. Surabaya: Universitas Katolik Widya Mandala.
Manaf A. 2010. Targeting postprandial hyperglycaemia: Evidence for cardio vascular benefits with acarbose intervention. Sub bagian Metabolik Endokrin Bagian Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Andalas. http://repository.unand.ac.id/86/1/Targeting_Postprandial_Hyperglycaemia.pdf.
Ndraha, S. 2014. Diabetes Melitus tipe 2 dan tatalaksana terkini. Medicinus 27(2):9–16.
Node K, Inoue T. 2009. Postprandial hyperglycemia as an etiological factor in vascular failure. Cardiovasc Diabetol 8(23):1–10.
Nugraha DR, Yusuf AL. 2015. Efek antihiperglikemik ekstrak etanol dan ekstrak heksan biji petai cina (Leucaena glauca, Benth) pada tikus putih jantan diabetes yang diinduksi aloksan 2(1):1–10. https://docplayer.info/44924250-Efek-antihiperglikemikektsrak-etanol-dan-ekstrak-heksan-biji-petai-cina.html.
Parmawati RRPI. 2014. Efek ekstrak etanol pohon ciplukan (Physalis angulata L) terhadap penurunan konsentrasi gula darah tikus jantan galur wistar yang diinduksi dengan aloksan tetrahidrat [Skripsi]. Jakarta: Universitas Pembangunan Nasional Veteran Jakarta.
Seino Y, Fukushima M, Yabe D. 2010. GIP and GLP-1 the two incretin hormones: similarities and differences. J Diabetes Investig 1(1–2):8–23.
Shofiyullah M. 2015. Identifikasisenyawa aktif dan uji potensi antimalaria ekstrak etanol 80% batang widuri (Calotropis gigantea) pada hewan coba yang terinfeksi Plasmodium berghei [Undegraduate Prosiding] Penelitian Sivitas AkademikaUnisba (Kesehatan) (page 955–961), Gelombang 2 Tahun Akademik 2014-2015. Bandung: Universitas Islam Bandung.
Silvita SD, Sastramihardja SH, Rukanta D. 2015. Efek Pemberian Infusa Biji Petai China (Leucaena leucocephala) dalam Menurunkan Konsentrasi Glukosa Darah Puasa Pada Mencit Model Diabet
Suryanti AP, Artawan IK, Martriani NAT. 2016. Potensi Ektrak Kasar Biji Lamtoro Gung (Leucaena leucocephala) Untuk Menurunkan Glukosa Darah Tikus Putih. Prosiding Seminar Nasional MIPA 2016 (page 287–295), 30th July Bali: FMIPA Undiksha.
Utami M, Wowor MP, Mambo C. 2015. Uji efek pemberian ekstrak biji petai cina(Leucaena leucocephala L) terhadapkonsentrasi gula darah tikus wistar (Rattus norvegicus) yang diinduksialoksan. Jurnal e-Biomedik 3(1):363–367.
Willihnganz C. 2013. Basic Pharmacology for Nurses. Sixteen Edition. Canada: Elsevier.
[WHO] World Health Organization. 2016. Diabetes. http://www.who.int/mediacentrefactsheets/fs312/en/ [Acessed 18 Septem-ber 2016].
Yuriska A. 2009. Efek aloksan terhadap konsentrasi glukosa darah tikus wistar [Undergraduated Thesis]. Semarang: Universitas Diponegoro. Thesis]. Malang: UIN Maulana Malik Ibrahim.
Authors
PujanggaI. W., NainggolanD., & ThadeusM. S. (2019). Effects of Leadtree Seed (Leucaena leucocephala) Extract in Inhibiting the Increase of Postprandial Blood Glucose Level in Alloxan-induced Diabetic Rats. Jurnal Gizi Dan Pangan, 14(3), 157-164. https://doi.org/10.25182/jgp.2019.14.3.157-164
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