In Vitro α-Glucosidase Inhibition and Antioxidant Activity of Mulberry (Morus Alba L.) Leaf Ethanolic Extract

  • Hasim Muhamad Danuri Department of Biochemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, Indonesia
  • Widia Ayu Lestari Department of Biochemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, Indonesia
  • Uci Sugiman Department of Biochemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, Indonesia
  • Didah Nur Faridah Department of Food Science and Technology, Faculty of Agricultural Engineering and Technology, IPB University, Bogor 16680, Indonesia 3 and Southeast Asian Food & Agriculture Science & Technology (SEAFAST) Center, IPB University, Bogor 16680, Indonesia
Keywords: α-glucosidase, antioxidant, mulberry, thiobarbituric acid

Abstract

This present work aimed to investigate the in vitro antioxidant activity and α-glucosidase inhibitory effect of mulberry leaf ethanolic extract. Antioxidant analysis was performed using Thiobarbituric Acid (TBA) assay at concentrations of 125, 200, 500, and 1,000 ppm. The results showed that the optimum incubation time was four days and the extracts could reduce the formation of MDA, i.e. 41.21%, 45.33%, 44.19%, and 36.00%, respectively. This suggests that concentration of 200 ppm was found as the best treatment. In addition, the result showed that ethanolic extract of mulberry leaf also showed inhibition against α-glucosidase with the IC50 of 309.82 µg/ml.

Downloads

Download data is not yet available.

Author Biography

Hasim Muhamad Danuri, Department of Biochemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, Indonesia

biochemistry and toxicology

Published
2020-03-28
How to Cite
Danuri, H. M., Lestari, W. A., Sugiman, U., & Faridah, D. N. (2020). In Vitro α-Glucosidase Inhibition and Antioxidant Activity of Mulberry (Morus Alba L.) Leaf Ethanolic Extract. Jurnal Gizi Dan Pangan, 15(1), 45-52. https://doi.org/10.25182/jgp.2020.15.1.45-52
Section
Articles