Fructose Intake Related with Serum Uric Acid Level in Young Adults
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Issue
Vol. 14 No. 3 (2019)
Accepted
26 November 2019
Published
26 November 2019
Keywords:
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blood pressure, fructose intake, uric acid
Abstract
This study aimed to clarify the correlation of fructose intake with uric acid level and blood pressure in young adults. This study used a cross-sectional design, conducted in Padang, West Sumatera province of Indonesia in 2014. The subjects consist of 109 students of Medical Faculty of Andalas University, aged 18–23 years old, were randomly selected to participate. Data on fructose intake were obtained using food frequency questionnaire. Uric acid levels was determined by the enzymatic colorimetric method. Resting blood pressure was measured twice using a sphygmomanometer. Data were analyzed using Rank-Spearman correlation test. The median of fructose intake was 74.3 g (min 23.4–max 160.2). The median of systolic blood pressure was 117 mmHg (min 100–max 145) and median of diastolic blood pressure was 70 mmHg (min 60–max 90). The mean uric acid levels was 5.2±1.56 mg/dl and 25% of the male subject had high uric acid levels. Fructose intake had no significant correlation with SBP (r=0.026; p=0.851) nor with DBP (r=0.051; p=0.712). However, there was a strong correlation between fructose intake with uric acid level (r=0.660; p<0.001). The study found that fructose intake shows a strong correlation with uric acid level but not with blood pressure in young adult.
References
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Angelopoulos TJ, Lowndes J, Sinnett S, Rippe JM. 2015. Fructose containing sugars do not raise blood pressure or uric acid at normal levels of human consumption. J Clin Hypertens 17(2):87–94.
Barone S, Fussell SL, Singh AK, Lucas F, Xu J, Kim CK, Wu X, Yu Y, Amlal H, Seidler U et al. 2009. Slc2a5 (Glut5) is essensial for the absorption of fructose in the intestine and generation of fructose-induced hypertension. J Biol Chem 284(8):5056–5066.
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Brown CM, Dullo AG, Yepuri G, Montani JP. 2008. Fructose ingestion acutely elevates blood pressure in healthy young human. Am J Physiol Regul Integr Comp Physiol. 294(3):730–737.
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, et al. 2003. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of High Blood Pressure. Hypertension 42(6):1206–1252.
Choi HK, Curhan G. 2008. Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study. BMJ 336(7639):309–312.
Choi JWJ, Ford ES, Gao X, Choi HK. 2008. Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: The third national health and nutrition examination survey. Arthritis Care and Research 59(1):109–116.
Doran KS, Mills KT, Liu Y, He J. 2018. Trends in prevalence and control of hypertension according to the 2017 american college of cardiology/american heart association guideline. J Am Heart Assoc 7(11):e008888.
Desmawati D. 2017. Pengaruh asupan tinggi fruktosa terhadap tekanan darah. Majalah Kedokteran Andalas 40(1):31–39.
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Dhingra R, Sullivan L, Jacques PF, Wang TJ, Fox CS, Meigs JB, DAgostino RB, Gaziano JM, Vasan RS. 2007. Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation 116(5):480–488.
Febriyani NMPS, Hardinsyah, Briawan D. 2012. Minuman berkalori dan kontribusinya terhadap tota asupan energi remaja dandewasa. J Gizi Pangan 7(1):35–42.
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Jalal DI, Smits G, Johnson RJ, Chonchol M. 2010. Increased fructose associates with elevated blood pressure. J Am Soc Nephrol 21(9):1543–1549.
Kotsis V, Stabouli S, Papakatsika S, Rizos Z, Parati G. 2010. Mechanisms of obesity induced hypertension. Hypertension Res 33(5):386–393.
Lin WT, Huang HL, Huang MC, Chan TF, Ciou SY, Lee CY, Chiu YW, Duh TH, Lin PL, Wang TN et al. 2013. Effects on uric acid, body mass index, and blood pressure in adolescents of consuming beverages sweetened with high-fructose corn syrup. Int J Obes 37(4): 532–539.
[MoH] Ministry of Health. 2007. Indonesian Basic Health Research 2007. Jakarta: Ministry of Health Indonesia.
[MoH] Ministry of Health. 2018. Indonesian Basic Health Research 2018. Jakarta: Ministry of Health Indonesia.
Nguyen S, Choi HK, Lustig RH, Hsu CY. 2009. Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr 154(6):807–813.
Nyby MD, Abedi K, Smutko V, Eslami P, Tuck ML. 2007. Vascular angiotensin type 1 receptor expression is associated with vascular dysfunction, oxidative stress and inflammation in fructose-fed rats. Hypertens Res 30(5):451–457.
Perez-Poso S, Schold J, Nakagawa T, Sanchez-Lozada L, Johnson R, Lillo JL. 2010. Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. Int J Obes 34(3):454–461.
Rizkalla SW. 2010. Health implications of fructose consumption: A review of recent data. Nutr Metab 7(82). doi:10.1186/1743-7075-7-82.
Rho YH, Zhu Y, Choi HK. 2011. The epidemiology of uric acid and fructose. Seminars in Nephrology 31(5):410–419.
Sun ZS, Flickinger BD, Williamson-Hughes PS, Empie MW. 2010. Lack of association between dietary fructose and hyperuricemia risk in adults. Nutr Metab 7(16):1–12.
Tappy L, Kim-Anne L. 2010. Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev 90(1):23–40.
Wang DD, Sievenpiper JL, de-Souza RJ, Chiavaroli L, Ha V, Cozma AI, Mirrahimi A, Yu ME, Carleton AJ, Buono MD et al. 2012. The Effect of fructose intake on serum uric acid vary among controlled dietary trials. J Nutr 142(5):916–923.
[WHO] World Health Organization. 2012. Overweight and obesity. World Health Organization. https://www.who.int/gho/ncd/risk_factors/overweight/en/ [Accessed 12 April 2017].
Angelopoulos TJ, Lowndes J, Sinnett S, Rippe JM. 2015. Fructose containing sugars do not raise blood pressure or uric acid at normal levels of human consumption. J Clin Hypertens 17(2):87–94.
Barone S, Fussell SL, Singh AK, Lucas F, Xu J, Kim CK, Wu X, Yu Y, Amlal H, Seidler U et al. 2009. Slc2a5 (Glut5) is essensial for the absorption of fructose in the intestine and generation of fructose-induced hypertension. J Biol Chem 284(8):5056–5066.
Bray GA, Nielsen SJ, Popkin BM. 2004. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 79 (4):537–43
Brown CM, Dullo AG, Yepuri G, Montani JP. 2008. Fructose ingestion acutely elevates blood pressure in healthy young human. Am J Physiol Regul Integr Comp Physiol. 294(3):730–737.
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, et al. 2003. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of High Blood Pressure. Hypertension 42(6):1206–1252.
Choi HK, Curhan G. 2008. Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study. BMJ 336(7639):309–312.
Choi JWJ, Ford ES, Gao X, Choi HK. 2008. Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: The third national health and nutrition examination survey. Arthritis Care and Research 59(1):109–116.
Doran KS, Mills KT, Liu Y, He J. 2018. Trends in prevalence and control of hypertension according to the 2017 american college of cardiology/american heart association guideline. J Am Heart Assoc 7(11):e008888.
Desmawati D. 2017. Pengaruh asupan tinggi fruktosa terhadap tekanan darah. Majalah Kedokteran Andalas 40(1):31–39.
Desmawati D, Lestari Y, Fasrini UU, Sulastri D. 2019. Correlation nutritional status with uric acid level in Minangkabau men ethnicity . Int J Res Med Sci. 7(1):131–134. DOI:http://dx.doi.org/10.18203/23206012.ijrms20185367.
Dhingra R, Sullivan L, Jacques PF, Wang TJ, Fox CS, Meigs JB, DAgostino RB, Gaziano JM, Vasan RS. 2007. Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation 116(5):480–488.
Febriyani NMPS, Hardinsyah, Briawan D. 2012. Minuman berkalori dan kontribusinya terhadap tota asupan energi remaja dandewasa. J Gizi Pangan 7(1):35–42.
Gee M, Mahan LK, Escott-Stump S.2008. Weight management, in Krause's food & nutrition therapy. Canada: Saunders Elsevier.
Jalal DI, Smits G, Johnson RJ, Chonchol M. 2010. Increased fructose associates with elevated blood pressure. J Am Soc Nephrol 21(9):1543–1549.
Kotsis V, Stabouli S, Papakatsika S, Rizos Z, Parati G. 2010. Mechanisms of obesity induced hypertension. Hypertension Res 33(5):386–393.
Lin WT, Huang HL, Huang MC, Chan TF, Ciou SY, Lee CY, Chiu YW, Duh TH, Lin PL, Wang TN et al. 2013. Effects on uric acid, body mass index, and blood pressure in adolescents of consuming beverages sweetened with high-fructose corn syrup. Int J Obes 37(4): 532–539.
[MoH] Ministry of Health. 2007. Indonesian Basic Health Research 2007. Jakarta: Ministry of Health Indonesia.
[MoH] Ministry of Health. 2018. Indonesian Basic Health Research 2018. Jakarta: Ministry of Health Indonesia.
Nguyen S, Choi HK, Lustig RH, Hsu CY. 2009. Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr 154(6):807–813.
Nyby MD, Abedi K, Smutko V, Eslami P, Tuck ML. 2007. Vascular angiotensin type 1 receptor expression is associated with vascular dysfunction, oxidative stress and inflammation in fructose-fed rats. Hypertens Res 30(5):451–457.
Perez-Poso S, Schold J, Nakagawa T, Sanchez-Lozada L, Johnson R, Lillo JL. 2010. Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. Int J Obes 34(3):454–461.
Rizkalla SW. 2010. Health implications of fructose consumption: A review of recent data. Nutr Metab 7(82). doi:10.1186/1743-7075-7-82.
Rho YH, Zhu Y, Choi HK. 2011. The epidemiology of uric acid and fructose. Seminars in Nephrology 31(5):410–419.
Sun ZS, Flickinger BD, Williamson-Hughes PS, Empie MW. 2010. Lack of association between dietary fructose and hyperuricemia risk in adults. Nutr Metab 7(16):1–12.
Tappy L, Kim-Anne L. 2010. Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev 90(1):23–40.
Wang DD, Sievenpiper JL, de-Souza RJ, Chiavaroli L, Ha V, Cozma AI, Mirrahimi A, Yu ME, Carleton AJ, Buono MD et al. 2012. The Effect of fructose intake on serum uric acid vary among controlled dietary trials. J Nutr 142(5):916–923.
[WHO] World Health Organization. 2012. Overweight and obesity. World Health Organization. https://www.who.int/gho/ncd/risk_factors/overweight/en/ [Accessed 12 April 2017].
Authors
DesmawatiD., FasriniU. U., AfrianiN., & SulastriD. (2019). Fructose Intake Related with Serum Uric Acid Level in Young Adults. Jurnal Gizi Dan Pangan, 14(3), 135-140. https://doi.org/10.25182/jgp.2019.14.3.135-140
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