Efficacy of propolis supplementation to accelerate healing process and body weight recovery of pulmonary tuberculosis patients
Article Sidebar
Issue
Vol. 13 No. 1 (2018)
Accepted
13 November 2017
Published
28 March 2018
Keywords:
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body weight, healing, liquid propolis, pulmonary Tb
Abstract
This study aimed to evaluate the pace of curing process and body weight recovery of pulmonary tuberculosis (Tb) patients receiving propolis supplementation. This study was a randomized controlled trial conducted on 50 pulmonary Tb patients that were assigned into three groups as follows: receiving standard-dose antituberculosis drugs (ATDs) + 20 drops of placebo propolis (P0); receiving standard-dose ATDs + 20 drops of propolis with concentration of 6% (P1); and receiving standard-dose ATDs + 20 drops of propolis with concentration of 30% (P2). The results showed that the mean time ratio needed for sputum smear conversion to negative present of acid resitant bacteria in P0, P1 and P2 groups were weeks 10, 8 and 5, respectively. In the second week, mean body weight of P0 and P1 groups decreased by 2.4% and 0.2%, respectively. In contrast, the mean body weight in P2 group increased by 1.5% (p<0.05; Mann-Whitney test). In the same week, mean body mass index (BMI) of P0 and P1 groups decreased by 1.6 and 0.1, respectively. Conversely, the mean BMI of P2 group increased by 0.3. The changes were significantly different (p<0.05). The results conclusively indicated that supplementation of 20 drops of propolis with a concentration of 30% as an adjuvant to standard ATDs for the treatment of pulmonary Tb patients was beneficial to accelerate treatment effect and body weight recovery.
References
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Moses AO, Emmanuel OO, Ganiyu AO, Fidelis AA, Dickson AO. 2009. Assessment of antioxidants and nutritional status of pulmonary tuberculosis patients in Nigeria. Eur J Gen Med 5(4):208-211
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Scazzocchio F, D’Auria FD, Alessandrini D, Pantanella F. 2006. Multifactorial Aspects of Antimicrobial of Propolis. Microbiological Research 161(4):327-333.
Scheller S, Dworniczak S, Waldemar-Klimmek K, Rajca M, Tomczyk A, Shani J. 1999. Synergism between ethanolic extract of propolis (EEP) and anti-tuberculosis drugs on growth of mycobacteria. Naturforsch C 54(7-8):549-53.
Semba RD, Bloem MW. 2001. Nutrition and Health in Developing Countries. New Jersey: Humana Press.
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Sultan KM, Alobaidy MW, Al-Jubouri AM, Naser AA, Al-Sabah HA. 2012. Assessment of body mass index and nutritional status in pulmonary tuberculosis patients. J Fac Med Baghdad 54:204-208.
Syamsudin, Dewi RM, Kusmardi. 2008. Immunomodulatory and in vivo Antiplasmodial Activities of Propolis Extracts. Global Journal of Pharmacology 2(3):37-40.
Toreti VC, Sato HH, Pastore GM, Park YK. 2013. Recent Progress of Propolis for Its Biological and Chemical Compositions and Its Botanical Origin. Hindawi Publishing Corporation, Evidence-Based Complementary and Alternative Medicine. Volume 2013, Article ID 697390, 13 pages.
Tungdim MG, Kapoor S. 2008. Tuberculosis treatment and nutritional status among the tribals of Northeast India. Acta Biol. Szeged 52:323-327.
Wahyunitisari MR, Mertaniasih NM, Rachmawati D. 2006. Antimicrobial activities of andrographolide and propolis against intracellular Mycobacterium tuberculosis phagocytosed by monocytes derived macrophages. Folia Medica Indones 42:22-27.
[WHO] World Health Organization, 2016. Global Tuberculosis Report 2016. World Health Organization, Geneva, Switzerland.
[WHO] World Health Organization, 2013. Global Tuberculosis Report 2013. World Health Organization, Geneva, Switzerland.
Cantrell CL, Franzblau SG, Fischer NH. 2001. Antimycobacterial plant terpenoids. Planta Med. 67:685-694.
Cevik MU, Acar A, Tanriverdi H, Varol S, Arikanoglu A, Yucel Y, Akil E, Yunce M, Ekinci A. 2012. Toxic Effects of Isoniazid and Rifampicin on Rat Brain Tissue: The Preventive Role of Caffeic Acid Phenethyl Ester. Int J Pharmacol 8:555-560.
Chow SC, Liu JP. 2004. Design and Analysis of Clinical Trials : Concepts and Methodologies. 2nd ed. John Wiley & Sons, Inc. New Jersey : Hoboken.
Chowdhury A, Santra A, Bhattacharjee K, GhatakS, Saha DR, Dhali GK. 2006. Mitochondrial oxidative stress and permeability transition in Isoniazid and Rifampicin induced liver injury in mice. J. Hepatol. 45, 117-126. doi:10.1016/j.jhep.2006.01.027
Chung-Delgado K, Revilla-Montag A, Guillén-Bravo S, Bernabe-Ortiz A. 2014. Weight variation over time and its relevance among multidrug-resistant tuberculosis patients. Int. J. Infect. Dis. 23, 20–24. doi:10.1016/j.ijid.2014.01.001
[Depkes] Departemen Kesehatan. 2009. Profil Kesehatan Indonesia 2008. Departemen Kesehatan Republik Indonesia, Jakarta.
Gershwin ME, Nestel P, Keen CL. 2004. Handbook of Nutrition and Immunity. Humana Press Inc. Totowa, New Jersey.
Halim E, Hardinsyah, Sutandyo N, Sulaeman A, Artika M, Harahap Y. 2012. Kajian Bioaktif dan Zat Gizi Propolis Indonesia dan Brasil. J Gizi Pangan 7(1):1-6.
Hashmi N, Muhammad F, Javed I, Khan JA, Khan MZ, Khaliq T, Aslam B. 2013. Nephroprotective effects of Ficus religiosa linn (peepal plant) stem bark against isoniazid and rifampicin induced nephrotoxicity in albino rabbits. Pak Vet J 33:330-334.
Katerere DR, Gray AI, Nash RJ, Waigh RD. 2012. Phytochemical and Antimicrobial Investigations of Stilbenoids and Flavonoids Isolated from Three Species of Combretaceae. Fitoterapia 83 (2012) 932–940
[Kemenkes] Kementerian Kesehatan Republik Indonesia. 2009. Keputusan Menteri Kesehatan Republik Indonesia Nomor 364/Menkes/Sk/V/2009 Tentang Pedoman Penanggulangan Tuberkulosis (Tb).
[Kemenkes] Kementerian Kesehatan Republik Indonesia. 2014. Pedoman Nasional Pengendalian Tuberkulosis. Kementerian Kesehatan Republik Indonesia. Direktorat Jenderal Pengendalian Penyakit dan Penyehatan Lingkungan.
Krol W, Scheller S, Shani J, Pietsz G, Czuba Z. 1993. Synergistic Effect of Ethanolic Extract of Propolis and Antibiotics on The Growth of Staphylococcus aureus. Arzneimittelforschung. 43(5):607-9.
Lombardo CC. 2012. The nutritional status of patients with tuberculosis in comparison with tuberculosis-free contacts in Delft, Western Cape. South Afr J Clin Nutr 25: 180-185.
Moses AO, Emmanuel OO, Ganiyu AO, Fidelis AA, Dickson AO. 2009. Assessment of antioxidants and nutritional status of pulmonary tuberculosis patients in Nigeria. Eur J Gen Med 5(4):208-211
Patra SK, Jain A, Sherwal BL, Khanna A. 2010. Nutritional Status in Multi Drug Resistance-Pulmonary Tuberculosis Patients . Int. J. Pharma and Bio Sciences V 1(2).
Pranandaru HA, Sembodo J, Choirina, Wijaya FK, Sewaka SW. 2011. Propolis Sebagai Suplemen Bagi Penderita Tuberkulosis Dewasa. PKM Penelitian. Dikti Kemendikbud.
Sari ID, Yuniar Y, Syaripuddin M, 2014. Studi Monitoring Efek Samping Obat Antituberkulosis Fdc Kategori 1 di Provinsi Banten dan Provinsi Jawa Barat. Media Penelitdan Pengemb Kesehat 24:28-35.
Scazzocchio F, D’Auria FD, Alessandrini D, Pantanella F. 2006. Multifactorial Aspects of Antimicrobial of Propolis. Microbiological Research 161(4):327-333.
Scheller S, Dworniczak S, Waldemar-Klimmek K, Rajca M, Tomczyk A, Shani J. 1999. Synergism between ethanolic extract of propolis (EEP) and anti-tuberculosis drugs on growth of mycobacteria. Naturforsch C 54(7-8):549-53.
Semba RD, Bloem MW. 2001. Nutrition and Health in Developing Countries. New Jersey: Humana Press.
Shetty P. 2010. Nutrition, Immunity and Infection. CABI Head Office Nosworthy Way 875.
Sudarsanam TD, Tharyan P. 2014. Rifampicin compared to isoniazid for preventing active Tb in HIV-negative people at risk of developing active Tb: Implications for public health. Clin. Epidemiol. Glob. Health 2, 28–36. doi:10.1016/j.cegh.2013.11.003
Sultan KM, Alobaidy MW, Al-Jubouri AM, Naser AA, Al-Sabah HA. 2012. Assessment of body mass index and nutritional status in pulmonary tuberculosis patients. J Fac Med Baghdad 54:204-208.
Syamsudin, Dewi RM, Kusmardi. 2008. Immunomodulatory and in vivo Antiplasmodial Activities of Propolis Extracts. Global Journal of Pharmacology 2(3):37-40.
Toreti VC, Sato HH, Pastore GM, Park YK. 2013. Recent Progress of Propolis for Its Biological and Chemical Compositions and Its Botanical Origin. Hindawi Publishing Corporation, Evidence-Based Complementary and Alternative Medicine. Volume 2013, Article ID 697390, 13 pages.
Tungdim MG, Kapoor S. 2008. Tuberculosis treatment and nutritional status among the tribals of Northeast India. Acta Biol. Szeged 52:323-327.
Wahyunitisari MR, Mertaniasih NM, Rachmawati D. 2006. Antimicrobial activities of andrographolide and propolis against intracellular Mycobacterium tuberculosis phagocytosed by monocytes derived macrophages. Folia Medica Indones 42:22-27.
[WHO] World Health Organization, 2016. Global Tuberculosis Report 2016. World Health Organization, Geneva, Switzerland.
[WHO] World Health Organization, 2013. Global Tuberculosis Report 2013. World Health Organization, Geneva, Switzerland.
Authors
MahaniM., SulaemanA., AnwarF., DamanikM. R. M., HardinsyahH., & PloegerA. (2018). Efficacy of propolis supplementation to accelerate healing process and body weight recovery of pulmonary tuberculosis patients. Jurnal Gizi Dan Pangan, 13(1), 1-10. https://doi.org/10.25182/jgp.2018.13.1.1-10
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