Hematologic profile in a Persian cat with osteosarcoma
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A three-year-old Persian cat presented to the West Java Provincial Veterinary Hospital with swelling in the left front leg and was diagnosed with osteosarcoma. This study aimed to evaluate the impact of osteosarcoma on the haematological profiles of cats. Humerus amputation is the standard treatment. A detailed haematological assessment was performed, including red blood cell count, white blood cells count, lymphocytes, monocytes, immature cells, mid-sized cells, granulocytes, haemoglobin, haematocrit, MCV, MCH, MCHC, and platelets. The findings revealed leukocytosis, granulocytosis, hypochromic macrocytic anaemia, and thrombocytopenia, indicating that osteosarcoma may disrupt the normal blood component production.
Beird HC, Bielack SS, Flanagan AM, Gill J, Heymann D, Janeway KA, Livingston JA, Roberts RD, Strauss SJ, Gorlick R. 2022. Osteosarcoma. Nature Reviews Disease Primers. 8(1):77. https://doi.org/10.1038/s41572-022-00409-y | PMid:36481668 DOI: https://doi.org/10.1038/s41572-022-00409-y
Childress MO. 2012. Hematologic abnormalities in the small animal cancer patient. Veterinary Clinics: Small Animal Practice. 42(1):123-55. https://doi.org/10.1016/j.cvsm.2011.09.009 | PMid:22285162 DOI: https://doi.org/10.1016/j.cvsm.2011.09.009
Cinti F, Martano M, Rossanese M, Selmic LE, Fontes GS, Cino M, Montinaro V, Tremolada G. 2024. Surgical treatment and outcome of primary rib tumours in cats: eight cases (2016‐2023). Journal of Small Animal Practice. 65(11):822-829. https://doi.org/10.1111/jsap.13770 | PMid:39113158 DOI: https://doi.org/10.1111/jsap.13770
Grigorakaki C, Morceau F, Chateauvieux S, Dicato M, Diederich M. 2011. Tumor necrosis factor alpha-mediated inhibition of erythropoiesis involves GATA-1/GATA-2 balance impairment and PU. 1 over-expression. Biochemical Pharmacology. 82(2):156-166. https://doi.org/10.1016/j.bcp.2011.03.030 | PMid:21501595 DOI: https://doi.org/10.1016/j.bcp.2011.03.030
Grindem CB, Breitschwerdt EB, Corbett WT, Page RL, Jans HE. 1994. Thrombocytopenia associated with neoplasia in dogs. Journal of Veterinary Internal Medicine. 8(6):400-405. https://doi.org/10.1111/j.1939-1676.1994.tb03258.x | PMid:7884725 DOI: https://doi.org/10.1111/j.1939-1676.1994.tb03258.x
Ma X, Zhao J, Feng H. 2023. Targeting iron metabolism in osteosarcoma. Discover Oncology. 14(1):31. https://doi.org/10.1007/s12672-023-00637-y | PMid:36897430 PMCid:PMC10006389 DOI: https://doi.org/10.1007/s12672-023-00637-y
Morrison WB. 2012. Inflammation and Cancer: A Comparative View. Journal of Veterinary Internal Medicine, 26(1):18-31. https://doi.org/10.1111/j.1939-1676.2011.00836.x | PMid:22151229 DOI: https://doi.org/10.1111/j.1939-1676.2011.00836.x
Nakano Y, Kagawa Y, Shimoyama Y, Yamagami T, Nomura K, Wakabayashi H, Sugiyama, Kobayashi T. 2022. Outcome of appendicular or scapular osteosarcoma treated by limb amputation in cats: 67 cases (1997-2018). Journal of the American Veterinary Medical Association. 260(S1):S24-S28. https://doi.org/10.2460/javma.21.04.0213 | PMid:34914624 DOI: https://doi.org/10.2460/javma.21.04.0213
Orosz Z, Athanasou NA. 2017. Giant cell-containing tumors of bone. Surgical Pathology Clinics. 10(3):553-573. https://doi.org/10.1016/j.path.2017.04.004 | PMid:28797502 DOI: https://doi.org/10.1016/j.path.2017.04.004
Roberts AW. 2005. G-CSF: a key regulator of neutrophil production, but that's not all!. Growth Factors. 23(1):33-41. https://doi.org/10.1080/08977190500055836 | PMid:16019425 DOI: https://doi.org/10.1080/08977190500055836
Watson J, Mounce L, Bailey SE, Cooper SL, Hamilton W. 2019. Blood markers for cancer. BMJ (Clinical Research ed). 367(15774):1-4. https://doi.org/10.1136/bmj.l5774 | PMid:31611235 DOI: https://doi.org/10.1136/bmj.l5774
Zlatanova I, Pinto C, Bonnin P, Mathieu JR, Bakker W, Vilar J, Lemitre M, Voehringer D, Vaulont S, Peyssonnaux C, Silvestre JS. 2019. Iron regulator hepcidin impairs macrophage-dependent cardiac repair after injury. Circulation. 139(12):1530-1547. https://doi.org/10.1161/CIRCULATIONAHA.118.034545 | PMid:30586758 DOI: https://doi.org/10.1161/CIRCULATIONAHA.118.034545
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