Hubungan Penggunaan Antimikroba terhadap Resistansi pada Peternakan Unggas Broiler Mandiri di Kabupaten Bogor

  • Nofita Nurbiyanti CIVAS
  • Imron Suandy Directorate of Veterinary Public Health, Director General of Livestock and Animal Health Services, Ministry of Agriculture Republic of Indonesia
  • Sunandar Center for Indonesian Veterinary Analytical Studies (CIVAS)
  • Riana Aryani Arief Center for Indonesian Veterinary Analytical Studies
  • Putik Allamanda Balai Veteriner Subang
  • Gian Pertela PT Medion Farma Jaya
  • Budi Purwanto PT Medion Ardhika Bhakti
  • Hanan Daradjat PT Medion Ardhika Bhakti
  • Nuraini Triwijayanti Direktorat Kesehatan Masyarakat Veteriner
  • Kanti Puji Rahayu Balai Pengujian Mutu dan Sertifikasi Produk Peternakan, Bogor
  • Oli Susanti Balai Pengujian Mutu dan Sertifikasi Produk Peternakan, Bogor
  • Riska Desitania Balai Pengujian Mutu dan Sertifikasi Produk Peternakan, Bogor
  • Rianna Anwar Sani Department Biomolecular Health Sciences, Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University
  • David Speksnijder Department Biomolecular Health Sciences, Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University
  • Tagrid Dinar Department Biomolecular Health Sciences, Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University
  • Tri Satya Putri Naipospos Center for Indonesian Veterinary Analytical Studies
  • Jaap Wagenaar Department Biomolecular Health Sciences, Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University
Keywords: antimicrobials use, antimicrobials resistance, broiler farm, Escherichia coli

Abstract

The use of antimicrobials in livestock selects for antimicrobials resistance in the livestock sector what is a potential threat for human health. This study aims to determine the association between antimicrobials use and the incidence of resistance in commensal Escherichia coli in Indonesian broiler farms. Data was collected on the use of antimicrobials for 4-6 production periods on 19 independent broiler farms in Bogor Regency from 2019 to 2022 (97 cycles). At the end of one of the last cycles, a boot swab sample of the bedding/litter was taken and 25 E. coli strains were isolated per farm. A total of 475 isolates of E. coli were tested with Susceptibility using the microdilution (Sensititre®) method for determining phenotypic resistance. The association between the antimicrobials used (Treatment Frequency Used Daily Dose/TFUDD) in the long term (97 cycles) and the short term (in the end cycle in which the sample was taken, 19 cycles) with the proportion of resistance was analyzed using linear regression. Farms most frequently used antimicrobials which were categorized as Highest Priority Critically Important Antimicrobials/HPCIA for human medicine (WHO, 2019). From 475 isolates of E. coli that were isolated, it was seen that the population of E. coli shows a high percentage of non-wildtype isolates (here called ‘resistant’). The highest resistance was seen to antimicrobials ciprofloxacin (93%), ampicillin (88%), tetracycline (83%), sulfamethoxazole (75%), and trimethoprim (71%). Of the 5 classes of antimicrobials analyzed, a significant association was found between the frequency of antimicrobials treatment and the proportion of resistance to quinolones and tetracyclines (p<0.05) in long-term use, and macrolides (p<0.05) and tetracyclines (p<0.01) in short-term use.

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Author Biographies

Nofita Nurbiyanti, CIVAS

Employed by: Center for Indonesian Veterinary Analytical Studies (CIVAS)

Jl. RSAU No.4 Atang Senjaya, Kemang, Bogor District, West Java 16310 Indonesia
Phone:  (+62) 251-7592868
Facsimile:  -

 

Nofita is the office manager of the Center for Indonesian Veterinary Analytical Studies (CIVAS) since 2018. She is responsible for the program management of an internal organisation and external projects in CIVAS. She is currently supporting of CIVAS activities project. Furthermore, she also is a consultant for WOAH MPTF Indonesia (2021-2023). He lives in Bogor City, West Java, Indonesia.

 

EDUCATION

BVM: IPB University, Indonesia, 2006

Imron Suandy, Directorate of Veterinary Public Health, Director General of Livestock and Animal Health Services, Ministry of Agriculture Republic of Indonesia

Employed by: Directorate of Veterinary Public Health, Director General of Livestock and Animal Health Services, Ministry of Agriculture Republic of Indonesia

Jl. Harsono RM. No. 3, Ragunan, Pasar Minggu, Jakarta 12550 Indonesia
Phone      :  (+62) 21-7806131 / 7804116
Facsimile  :  (+62) 21-7806305

 

Dr Suandy is a deputy director of animal product safety control in the Directorate of Veterinary Public Health. He is responsible for the national Indonesian monitoring-surveillance program of animal product safety and is the supervisor for all Veterinary Public Health laboratories across the country. He is currently the coordinator of antimicrobial resistance activities in the animal health sector. He is an active participant in communication and discussion on the Regional Technical Working Group on AMR and will be an AMR focal point for Indonesia. Furthermore, he also is an OIE focal point on food safety (2015). Finally, he is currently a PhD Student at Utrecht University. He lives in Bogor City, West Java, Indonesia.

 

EDUCATION

MVPH: 4th MVPH Program at Chiang Mai University, Thailand and Freie Universitat Berlin, 2011

DVM: IPB University, Indonesia, 2005

BVM:  IPB University, Indonesia, 2003

Sunandar, Center for Indonesian Veterinary Analytical Studies (CIVAS)

Employed by: Center for Indonesian Veterinary Analytical Studies (CIVAS)

Jl. RSAU No.4 Atang Senjaya, Kemang, Bogor District, West Java 16310 Indonesia
Phone      :  (+62) 251-7592868
Facsimile :  -

 

Sunandar is a director executive of the Center for Indonesian Veterinary Analytical Studies (CIVAS) since 2018. He is responsible for the implementation program of internal organisation and external projects in CIVAS. He currently is the field coordinator of CIVAS activities project. Furthermore, he also is a consultant for WOAH MPTF Indonesia (2021-2023). He lives in Bogor City, West Java, Indonesia.

 

EDUCATION

DVM: IPB University, Indonesia, 2007

BVM: IPB University, Indonesia, 2005

Published
2022-10-28
Section
Penelitian / Research