Emerging therapeutic strategies for precision reproductive management of repeat breeder cattle
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Repeat breeding in cattle is failure to establish pregnancy after three or more services or artificial inseminations despite cycling and no abnormalities. This causes losses from reduced conception, repeated insemination, prolonged calving interval, maintenance costs, and calf production. This review evaluates mechanisms and management, emphasizing fertilization failure, embryonic death, and uterine function. Evidence shows that it is multifactorial, involving poor oocyte competence, mistimed insemination, endocrine dysfunction, heat stress, sperm transport failure, subclinical endometritis, impaired embryo–maternal communication, endometrial gene expression, and inadequate receptivity. Management requires precise strategies tailored to the pathway.
Ağaoğlu AR, Korkmaz AÖ, Aslan S, Kocamüftüoğlu M, Köker A, Çetin Y, Güngör Ö, Öztürk D, Saatcı M. 2020. The effects of Pre-synch-10 and Ovsynch on some endometrial Toll- and Nod-like receptor gene expressions in repeat breeder cows. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 26(1):111-120.
Aghamiri SM, Ahmadi MR, Haghkhah M, Derakhshandeh A. 2020. Identification of pathogenic microorganisms of repeat breeder dairy cows and a hyperimmune treatment approach. Asian Pacific Journal of Reproduction. 9(1):44-48. https://doi.org/10.4103/2305-0500.275528
Carbonari A, Burgio M, Frattina L, Cicirelli V, Rizzo A. 2024. Repeat breeder syndrome therapies in dairy cows: a review. Reproduction in Domestic Animals. 59(10):e14732. https://doi.org/10.1111/rda.14732 | PMid:39392176
Kasimanickam RK, Kasimanickam VR. 2020. IFNT, ISGs, PPARs, RXRs and MUC1 in day 16 embryo and endometrium of repeat-breeder cows, with or without subclinical endometritis. Theriogenology. 158:39-49. https://doi.org/10.1016/j.theriogenology.2020.09.001 | PMid:32927199
Nowicki A. 2021. Embryo transfer as an option to improve fertility in repeat breeder dairy cows. Journal of Veterinary Research. 65(2):231-237. https://doi.org/10.2478/jvetres-2021-0018 | PMid:34250309 PMCid:PMC8256464
Pérez-Marín CC, Quintela LÁ. 2023. Current insights in the repeat breeder cow syndrome. Animals. 13(13):2187. https://doi.org/10.3390/ani13132187 | PMid:37443985 PMCid:PMC10340006
Pongkapadang KN, Amrin A, Suharto RH, Yusuf M, Komba EVG, Layos JK N, Purba FY, Yusuf S. 2025. Prevalence and risk factors of repeat breeding in dairy cows in Cendana District, Enrekang Regency, South Sulawesi, Indonesia. Open Veterinary Journal. 15(9):4548-4557. https://doi.org/10.5455/OVJ.2025.v15.i9.61 | PMid:41200358 PMCid:PMC12588012
Rizzo A, Lillo E, Ceci E, Maggiolino A, Cicirelli V, Sciorsci RL. 2023. Scopolamine administration in repeat breeder cows on the day of heat. Theriogenology. 195:1-6. https://doi.org/10.1016/j.theriogenology.2022.10.003 | PMid:36265407
Villar SL, Pérez-Marín CC, Álvarez J, Acción A, Barrionuevo R, Becerra JJ, Peña AI, Herradón PG, Quintela LA, Yáñez U. 2025. A prospective study of the prevalence and predictive risk factors of repeat breeder syndrome in dairy cattle in the North of Spain. Animals. 15(2):266. https://doi.org/10.3390/ani15020266 | PMid:39858265 PMCid:PMC11762659
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