Symmetry dimethylarginine (SDMA) assay for diagnosis of kidney disease in dogs and cats: a mini review of case reports in Indonesia
Abstract
Symmetry Dimethylarginine (SDMA) is an important biomarker for early diagnosis of kidney disease. Studies suggest that SDMA is a more sensitive indicator of kidney function compared to traditional markers such as blood urea nitrogen (BUN) and creatinine. Since 2015, the International Renal Interest Society (IRIS) has established SDMA as one of the indicators for diagnosis and determining the stage of chronic kidney disease (CKD) in dogs and cats. SDMA assay use in veterinary clinics in Indonesia has empirically become more common. The aim of this study was to identify scientific reports on SDMA assay use in the diagnosis of kidney disease in dogs and cats in Indonesia. We performed a literature search in the Garuda portal and Google Scholar using the following keywords: “SDMA” or “Symmetry Dimethylarginine”, “dogs”, “cats” and “Indonesia”. The search strategy utilized English and Bahasa Indonesia, and the results were screened for relevance to the topic, and limited to studies conducted in Indonesia. Seven scientific articles in national and international journals reported the use of SDMA assay in cases of kidney disease in dogs or cats in Indonesia, published between 2021-2023. It is expected that SDMA assay use will continue to increase in veterinary practice settings in the country, and it is therefore critical to have a proper understanding of the advantages and limitations of SDMA use for kidney disease diagnosis.
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References
Bennington J, Lankford S, Magalhaes RS, Shankle D, Fanning J, Kar-tini C, Suparto I, Kusumawardhani W, Putra MA, Mariya S, Badlani G. 2021. Chemokine therapy in cats with experimental renal fibrosis and in a kidney disease pilot study. Frontiers in Veterinary Science. 8:646087. https://doi.org/10.3389/fvets.2021.646087 | PMid:33748219 PMCid:PMC7969654
Braff J, Obare E, Elliott J, Yerramilli M. 2014. Relationship between serum symmetric dimethylarginine concentration and glomerular filtration rate in cats. Journal of Veterinary Internal Medicine. 28(6):1699-1701. https://doi.org/10.1111/jvim.12446 | PMid:25272985 PMCid:PMC4895615
Brown CA, Elliott J, Schmiedt CW, Brown SA. 2016. Chronic kidney disease in aged cats. Veterinary Pathology. 53(2):309-326. https://doi.org/10.1177/0300985815622975 | PMid:26869151
Gunawan M, Amelia F, Resyana NN, R.C.F Z, Zaenab S, Widyaputri T. 2023. IRIS-stage 4 CKD in a dog: diagnostic approaches and staging of chronic kidney disease: a case study. Journal of Experimental Biology and Agricultural Sciences. 11(1):216-125. https://doi.org/10.18006/2023.11(1).216.225
Hillaert A, Liu DJ, Daminet S, Broeckx BJ, Stock E, Paepe D, Hesta M, Vanderperren K. 2021. Serum symmetric dimethylarginine shows a relatively consistent long-term concentration in healthy dogs with a significant effect of increased body fat percentage. Plos one. 16(2):e0247049. https://doi.org/10.1371/journal.pone.0247049 | PMid:33596230 PMCid:PMC7888620
Hokamp JA, Nabity MB. 2016. Renal biomarkers in domestic species. Veterinary Clinical Pathology. 45(1):28-56. https://doi.org/10.1111/vcp.12333 | PMid:26918420
Kielstein JT, Fliser D, Veldink H. 2009. Progress in uremic toxin research: asymmetric dimethylarginine and symmetric dimethylarginine: axis of evil or useful alliance? Seminars in Dialysis. 22(4):346-50. https://doi.org/10.1111/j.1525-139X.2009.00578.x | PMid:19708979
Lo HC, Winter JC, Merle R, Gehlen H. 2021. Symmetric dimethylarginine and renal function analysis in horses with dehydration. Equine Veterinary Journal. 54(4):670-678. https://doi.org/10.1111/evj.13484 | PMid:34110650
Nabity MB, Lees GE, Boggess MM, Yerramilli M, Obare E, Yerramilli M, Rakitin A, Aguiar J, Relford R. 2015. Symmetric dimethylarginine assay validation, stability, and evaluation as a marker for the early detection of chronic kidney disease in dogs. Journal of Veterinary Internal Medicine. 29(4):1036-1044. https://doi.org/10.1111/jvim.12835 | PMid:26079532 PMCid:PMC4895368
O'neill DG, Elliott J, Church DB, McGreevy PD, Thomson PC, Brodbelt DC. 2013. Chronic kidney disease in dogs in UK veterinary practices: prevalence, risk factors, and survival. Journal of veterinary internal medicine. 27(4):814-821. https://doi.org/10.1111/jvim.12090 | PMid:23647231
Pelander L, Häggström J, Larsson A, Syme H, Elliott J, Heiene R, Ljungvall I. 2019. Comparison of the diagnostic value of symmetric dimethylarginine, cystatin C, and creatinine for detection of decreased glomerular filtration rate in dogs. Journal of veterinary internal medicine. 33(2):630-639. https://doi.org/10.1111/jvim.15445 | PMid:30791142 PMCid:PMC6430914
Permatasari SNI, Batan IW, Erawan IGMK. 2023. Laporan kasus: anaplasmosis dan ehrlichiosis pada anjing husky siberia penderita penyakit ginjal kronis. Indonesia Medicus Veterinus. 12(5):688-700. https://doi.org/10.19087/imv.2023.12.5.688
Pradnyani GAPI, Widiastuti SK, Erawan IGMK. 2021. Laporan kasus: menangani penyakit ginjal kronis pada anjing peranakan pomeranian. Indonesia Medicus Veterinus. 10(3):517-531. https://doi.org/10.19087/imv.2021.10.3.517
Pridayanti NKN, Anthara MS, Widyastuti SK. 2023. Infeksi saluran kemih bawah penyebab azotemia post-renal pada kucing persia campuran. Buletin Veteriner Udayana. 647. https://doi.org/10.24843/bulvet.2023.v15.i04.p17
Rysz J, Gluba-Brzózka A, Franczyk B, Jabłonowski Z, Ciałkowska-Rysz A. 2017. Novel biomarkers in the diagnosis of chronic kidney disease and the prediction of its outcome. International Journal of Molecular Sciences. 18(8):1702. https://doi.org/10.3390/ijms18081702 | PMid:28777303 PMCid:PMC5578092
Santis FD, Boari A, Dondi F, Crisi PE. 2022. Drug-dosing adjustment in dogs and cats with chronic kidney disease. Animals. 12(3):262. https://doi.org/10.3390/ani12030262 | PMid:35158584 PMCid:PMC8833495
Sargent HJ, Elliott J, Jepson RE. 2021. The new age of renal bi-omarkers: does SDMA solve all of our problems? Journal of Small Animal Practice. 62(2):71-81. https://doi.org/10.1111/jsap.13236 | PMid:33184865
Smith L, Bonde RK, Nau MR, Ball RL. 2023. Preliminary evaluation of symmetric dimethylarginine as a biomarker of renal insufficiency in wild and rehabilitated florida manatees (Trichechus manatus latirostris). Journal of Zoo and Wildlife Medicine. 54(2). https://doi.org/10.1638/2021-0133
Sulistiawati E, Zulfitra Utami Putri, Cucu K. Sajuthi. 2023. Analisis serum symmetric dimethylarginine dalam berbagai gejala klinis pada anjing. Acta VETERINARIA Indonesiana. 11(3):244-9. https://doi.org/10.29244/avi.11.3.244-249
Witoko MC, Suartha IN, Widyastuti S. 2022. Case report: chronic kidney failure in local dog. Journal of Veterinary and Animal Sciences. 5(2):53-64.
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