Antidiabetic and Hypolipidemic Potential of Cow’s Milk Yogurt with the Addition of Herbal Extracts in Diabetic Rats
Abstract
Yogurt, with the addition of herbal ingredients can add efficacy and value of its benefits. Several studies have proven that cinnamon, aloe vera, and fenugreek seeds have properties as antidiabetic and hypolipidemic. The purpose of this study was to evaluate the antidiabetic and hypolipidemic potential of yogurt with the addition of a combination of two or three types of herbal extracts, such as cinnamon, fenugreek seeds, and aloe vera, in diabetic rats. Diabetic rats were divided into six groups and given treatment for 21 days. Rats’ blood was taken to test blood glucose levels using glucometers, insulin with the ELISA method, blood lipid profiles, and kidney and liver functions using a chemistry analyzer. The data were statistically analyzed using one-way ANOVA followed by the Duncan test. The results showed that yogurt added with several combinations of herbal extracts such as cinnamon, aloe vera, and fenugreek seeds (III, IV, V, and VI) could significantly reduce blood glucose levels, increase insulin levels, improve lipid profiles, and improve kidney and liver functions in diabetic rats, as well as commercial administration of glibenclamide (II). Diabetic rats given yogurt with the addition of a combination of 3 herbal extracts (VI) and a combination of 2 herbal extracts (cinnamon +fenugreek seeds) (V) of 1% each showed better antidiabetic and hypolipidemic performances compared to the other groups (III, and IV). The combination of yogurt with some herbal extracts can add efficacy and value to the benefits of yogurt as a functional drink.
References
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Amnah & M. A. Alsuhaibani. 2016. Physicochemical, organoleptic, and antidiabetic, properties of yoghurt fortified with olive leaves. Middle East Journal Applied Sciences 6:341-348.
Barazzoni, R., C. G. Gortan, M. Ragni, & E. Nisoli. 2018. Insulin resistance in obesity: An overview of fundamental alterations. Eat Weight Disord. 23:149–157. https://doi.org/10.1007/s40519-018-0481-6
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Chaudhury, A., C. Duvoor, V. S. R. Dendi, S. Kraleti, A. Chada, R. Ravilla, A. Marco, N. S. Shekhawat, M. T. Montales, & K. Kuriakose. 2017. Clinical review of antidiabetic drugs: Implications for type 2 diabetes mellitus management. Front. Endocrinol. 8:1-12. https://doi.org/10.3389/fendo.2017.00006
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Devaraj, S., Y. Mesfin, A. B. Lidia, J. Ishwarlal, S. Sital, & J. Qi. 2013. Effects of Aloe vera supplementation in subjects with prediabetes/metabolic syndrome. Metab. Syndr. Relat. Disord. 11:35-40. https://doi.org/10.1089/met.2012.0066
Hamidpour, R., M. Hamidpour, S. Hamidpour, & M. Shahlari. 2015. Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of alzheimer’s disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities. J. Tradit. Complement. Med. 5:66–70. https://doi.org/10.1016/j.jtcme.2014.11.008
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Hsieh, F., C. Lee, C. Chai, W. Chen, Y. Lu, & C. Wu. 2013. Oral administration of Lactobacillus reuteri GMNL-263 improves insulin resistance and ameliorates hepatic steatosis in high fructose-fed rats. Nutr. Metab. 10:1–14. https://doi.org/10.1186/1743-7075-10-35
Hurrle, S. & W. H. Hsu. 2017. The etiology of oxidative stress in insulin resistance. Biomed. J. 40:257–262. https://doi.org/10.1016/j.bj.2017.06.007
Juniawati, Miskiyah, & A. Kusuma. 2020. Penambahan enkapsulan dalam proses pembuatan yoghurt powder probiotik dengan metode spray drying. Jurnal Penelitian Pascapanen Pertanian 16:56-63. https://doi.org/10.21082/jpasca.v16n2.2019.56-63
Kaminskas, A., J. A. Abaravičius, A. Liutkevičius, V. Jablonskienė, & J. Valiūnienė. 2013. Quality of yoghurt enriched by inulin and its influence on human metabolic syndrome. Veterinarija Ir Zootechnika 64:23-28.
Kang, H. S. & D. K. Yang. 2018. Anti-diabetic effect of cotreatment with quercetin and resveratrol in streptozotocin-induced diabetic rats. Biomol. Ther. 26:130–138. https://doi.org/10.4062/biomolther.2017.254
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Kottaisamy, C. P. D., D. S. Raj, P. Kumar, & U. Sankaran. 2021. Experimental animal models for diabetes and its related complications-a review. Lab. Anim. Res. 37:1-14. https://doi.org/10.1186/s42826-021-00101-4
Kumar, A., S. Aswal, A. Chauhan, R. B. Semwal, A. Kumar, & D. K. Semwal. 2019. Ethnomedicinal investigation of medicinal plants of Chakrata region (Uttarakhand) used in the traditional medicine for diabetes by Jaunsari tribe. Nat. Prod. Bioprospect. 9:175-200. https://doi.org/10.1007/s13659-019-0202-5
Kusumaningtyas, I. D., S. Fajariyah, & E. T. Utami. 2014. The effect of cinnamon (Cinnamomum burmanii) aqueous extract on pancreas structure of diabetic mice (Mus musculus) strain Balb-C. Jurnal Ilmu Dasar 15:69-73. https://doi.org/10.19184/jid.v15i2.813
Li, R., T. Liang, L. Xu, Y. Li, S. Zhang, & X. Duan. 2013. Protective effect of cinnamon polyphenols against stz diabetic mice fed high-sugar, high-fat diet and its underlying mechanism. Food Chem. Toxicol 51:419–425. https://doi.org/10.1016/j.fct.2012.10.024
Ligita, T., K. Wicking, K. Francis, N. Harvey, & I. Nurjannah. 2019. How people living with diabetes in Indonesia learn about their disease: A grounded theory study. PLoS One 14:1-19. https://doi.org/10.1371/journal.pone.0212019
Ma, W., L. Xiao, H. Liu, & X. Hao. 2022. Hypoglycemic natural products with in vivo activities and their mechanisms: a review. Food Science Human Wellness 11:1087-1100. https://doi.org/10.1016/j.fshw.2022.04.001
Mohamed, D. A., M. M. Hassanein, T. M. El-Messery, M. T. Fouad, M. M. El-Said, K. A. Fouda, & A. G. Abdel- Razek. 2017. Amelioration of diabetes in a rat model through yoghurt supplemented with probiotic and olive pomace extract. Int. J. Biol. Sci. 17:320-333. https://doi.org/10.3923/jbs.2017.320.333
Muhammad, D. R. A. & K. Dewettinck. 2017. Cinnamon and its derivatives as potential ingredient in functional food-a review. Int. J. Food Prop. 20:S2237–S2263.
Nagulapalli, V. K. C., A. Swaroop, D. Bagchi, & A. Bishayee. 2017. A small plant with big benefits: Fenugreek (Trigonella foenum graecum Linn.) for disease prevention and health promotion. Mol. Nutr. Food Res. 61:1600950. https://doi.org/10.1002/mnfr.201600950
National Research Council. 2011. Guide for The Care and Use of Laboratory Animals. 8th ed. National Academic Press, Washington, DC, US. p. 246.
National Research Council. 1995. Nutrient Requirements of Laboratory Animals. 4th ed. National Academy Press, Washington, DC, US. p. 29-30.
Ota, A. & N. P. Ulrih. 2017. An overview of herbal products and secondary metabolites used for management of type two diabetes. Front. Pharmacol. 8:1-14. https://doi.org/10.3389/fphar.2017.00436
Pal’chikova, N. A., V. G. Selyatitskaya, O. I. Kuz’minova, & K. V. Pasechnaya. 2018. Effects mifepristone on aminotransferase activities in the liver in rats with streptozotocin-induced diabetes mellitus. Bull. Exp. Biol. Med. 165:474–477. https://doi.org/10.1007/s10517-018-4197-4
Pothuraju, R., R. K. Sharma, S. K. Onteru, S. Singh, & S. A. Hussain. 2016. Hypoglycemic and hypolipidemic effects of aloe vera extract preparations: A review. Phytother. Res. 30:200–207. https://doi.org/10.1002/ptr.5532
Rustanti, N., V. Z. Nafsih, R. N. Avisha, D. M. Kurniawati, R. Purwanti, C. Nissa, H. S. Wijayanti, & D. N. Afifah. 2019. Pengaruh yoghurt dan soyghurt kayu manis (Cinnamomum burmannii) terhadap kadar glukosa darah, insulin serum, dan malondialdehyde tikus pra sindrom metabolik. Jurnal Gizi Indonesia 8:60-68. https://doi.org/10.14710/jgi.8.1.60-68
Saeedi, P., I. Petersohn, P. Salpea, B. Malanda, S. Karuranga, N. Unwin, S. Colagiuri, L. Guariguata, A. A. Motala, K. Orgutsowa, J. E. Shaw, D. Bright, & R. Williams. 2019. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the international diabetes federation diabetes atlas, 9th edition. Diabetes Res. Clin. Pract. 157:107843. https://doi.org/10.1016/j.diabres.2019.107843
Salehi, P., B. Asghari, M. A. Esmaeili, H. Dehghan, & I. Ghazi. 2013. α -Glucosidase and α -amylase inhibitory effect and antioxidant activity of ten plant extracts traditionally used in Iran for diabetes. Res. J. Medicinal Plant. 7:257–266.
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Authors
PazraD. F., PurwantiM., HandayaniK. S., Wahyuningsih, & WahyuwardaniS. (2023). Antidiabetic and Hypolipidemic Potential of Cow’s Milk Yogurt with the Addition of Herbal Extracts in Diabetic Rats. Tropical Animal Science Journal, 46(4), 494-501. https://doi.org/10.5398/tasj.2023.46.4.494
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