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Aktivitas inhibisi tirosinase ekstrak etanol rumput laut Ulva lactuca secara in vitro In vitro tyrosinase inhibitory activity of ethanol extract of seaweed Ulva lactuca
Abstract
Ulva lactuca is rich in bioactive compounds, which are beneficial to humans and other organisms. This study aimed to determine the tyrosinase inhibitory activity of an ethanol extract of U. lactuca seaweed in vitro. This research was carried out in stages, namely, the maceration process of U. lactuca with an ethanol solvent. The extract was liquid-liquid fractionated using n-hexane, chloroform, and water as solvents. The ethanol extracts and fractions were tested for total phenol, total flavonoid, and tyrosinase inhibitory activities. The highest total phenol and flavonoid values were obtained from the n-hexane fraction with values of 9.43±0.27 mgGAE/g and 9.20±0.49 mgQE/g. The highest tyrosinase inhibitory activity was obtained from the n-hexane fraction, with an IC50 value of 127.74±6.47 µg/mL. Active compounds that play an important role in tyrosinase inhibitory activity in the ethanol extract and n-hexane fraction include chalcone, ferulic acid, 4-nitrocinnamic acid, 4-aminobenzoic acid, 2TMS derivatives, 4-hydroxybenzoic acid, 4-tert-butylfenol, 1-tetradecanol, n-hexadecanoic acid methyl ester, palmitic acid, 2-(2-Aminophenyl)-1H-benzimidazole, and 5-methylsalicylic acid, which are thought to act as tyrosinase inhibitors in the ethanol extract and n-hexane fraction. Thus, the n-hexane fraction of U. lactuca could be used as a natural tyrosinase inhibitor.
References
Alagan, V., Valsala, R., & Rajesh, K. (2017). Bioactive chemical constituent analysis, in vitro antioxidant and antimicrobial activity of whole plant methanol extracts of Ulva Lactuca Linn. British Journal of Pharmaceutical Research, 15(1), 1–14.
Amri, E., Dharma, A., Armaini., & Tjong, D. H. (2017). Potency of microalgae as tyrosinase inhibitor. Journal of Pharmaceutical Biological and Chemical Sciences, 8(4), 577-581.
Arbi, B., Ma’ruf, W. F., & Romadhon, R. (2016). Aktivitas senyawa bioaktif selada laut (Ulva lactuca) sebagai antioksidan pada minyak ikan. Indonesian Journal of Fisheries Science and Technology (IJFST) Saintek Perikanan, 12(1), 12–18.
Arguelles, D. E., & Sapin, A. B. (2020). Bioactive properties of Sargassum siliquosum j. Agardh (fucales, ochrophyta) and its potential as source of skin-lightening active ingredient for cosmetic application. Journal of Applied Pharmaceutical Science, 10(7), 51–58.
Arguelles, E. D. L. R. (2021). Evaluation of antioxidant capacity, tyrosinase inhibition, and antibacterial activities of brown seaweed, Sargassum ilicifolium (Turner) C. Agardh 1820 for cosmeceutical application. Journal of Fisheries and Environment, 45(1): 64–77.
Arifianti, A. E., Anwar, E., & Nurjanah. (2017). Aktivitas penghambatan tirosinase dan antioksidan serbuk rumput laut dari Sargassum plagiophyllum segar dan kering. Jurnal Pengolahan Hasil Perikanan Indonesia, 20(3), 488–493.
Ashooriha, M., Khoshneviszadeh, M., Rafiei, A., Kardan, M., Yazdian-Robati, R., & Emami, S. (2020). Kojic acid–natural product conjugates as mushroom tyrosinase inhibitors. European Journal of Medicinal Chemistry, 201(1), 1-13
Aslan, E., Aksu, A., Korkmaz, N. E., Taskin, O. S., & Caglar, N. B. (2019). Monitoring the antioxidant activities by extracting the polyphenolic contents of algae collected from the bosphorus. Marine Pollution Bulletin, 141, 313–317.
Baek, S. H., Cao, L., Jeong, S. J., Kim, H. R., Nam, T. J., & Lee, S.G. (2021). The comparison of total phenolics, total antioxidant, and anti-tyrosinase activities of korean Sargassum species. Journal of Food Quality, 2012: 1-7
Badan Pengawas Obat dan Makanan Republik Indonesia (BPOM-RI). 2015. Peraturan Kepala Badan Pengawas Obat dan Makanan Republik Indonesia Nomor 18 Tahun 2015. Diakses pada Tanggal 12 Februari 2024 pada link: https://standar-otskk.pom.go.id/storage/uploads/9e774c2d-b936-4643-9ecf-30f9370d3f13/Perka-BPOM-No.-18-tahun-2015.pdf
Chan, Y. Y., Kim, K. H., & Cheah, S. H. (2011). Inhibitory effects of Sargassum polycystum on tyrosinase activity and melanin formation in b16f10 murine melanoma cells. Journal of Ethnopharmacology, 137(3), 1183–1188.
Chang, C., Yang, M.H., Wen, H. M., & Chern, J. C. (2002). Estimation of total flavonoid content in propolis by two complementary colorimetric methods. Journal of Food and Drug Analysis, 10(3), 178–182.
Cho, M. (2010). The antioxidant properties of ethanol extracts and their solvent-partitioned fractions from various green seaweeds. Journal of Medicinal Food, 13(5): 1232–1239.
Choosuwan, P., Praiboon, J., Boonpisuttinant, K., Klomjit, A., Muangmai, Ruangchuay, N., & Chirapart, A. (2023). Inhibitory Effects of Caulerpa racemosa, Ulva intestinalis, and Lobophora challengeriae on Tyrosinase Activity and α-MSH-Induced Melanogenesis in B16F10 Melanoma Cells. Life, 13(4), 3-16. https://doi.org/10.3390/LIFE13040934
Cui, Y., Hu, Y. H., Yu, F., Zheng, L. S., Chen, Q., Chen, X., & Q, Wang. (2017). Inhibition kinetics and molecular simulation of p-substituted cinnamic acid derivatives on tyrosinase. International Journal of Biological Macromolecules, 95: 1289–1297.
Di Petrillo, A., González-Paramás, A. M., Era, B. R., Medda, F., Pintus, C., Santos-Buelga., & Fais, A. (2016). Tyrosinase inhibition and antioxidant properties of asphodelus microcarpus extracts. BMC Complementary and Alternative Medicine, 16(1), 1-9
Dolorosa, M. T. (2019). Tyrosinase inhibitory activity of Sargassum plagyophyllum and Eucheuma cottonii methanol extracts. IOP Conference Series: Earth and Environmental Science, 278(1), 1–7.
Farasat, M., Khavari-Nejad, R. A., Nabavi, S. M. B., & Namjooyan, F. (2014). Antioxidant activity, total phenolics and flavonoid contents of some edible green seaweeds from Northern Coasts of The Persian Gulf. Iranian Journal of Pharmaceutical Research; 13(1): 163-170
Fathy, S. A., Mohamed, M. R., Emam, M. A., Mohamed, S. S., Ghareeb, D. A., Elgohary, S. A., & Abd-El Megeed, D. F. (2019). Therapeutic efficacy of seaweed extract (Ulva fasciata delile) against invasive candidiasis in mice. Tropical Biomedicine, 36(4): 972-986.
Fitri, A. C. K., & Proborini, W. D. (2018). Analisa komposisi minyak atsiri kulit jeruk manis hasil ekstraksi metode microwave hydrodiffusion and gravity dengan GC-MS. Jurnal Reka Buana, 3(1), 53-58.
Furi, M., Alfatma, A., Dona, R., Fernando, A., Aryani, F., Utami, R., & Octaviani, M. (2022). Uji inhibitor enzim tirosinase ekstrak dan fraksi daun kedabu (Sonneratia ovata backer) secara in vitro. Jurnal Ilmiah Manuntung, 8(2), 201-214.
Gazali, M., Nurjanah., Zamani, N. P. (2018). Eksplorasi senyawa bioaktif alga cokelat Sargassum sp. Agardh sebagai antioxidant dari Pesisir Barat Aceh. Jurnal Pengolahan Hasil Perikanan Indonesia. 21(1), 167-178.
Gazali, M., Nurjanah, Zamani, N.P. (2019a). The screening of bioactive compound of the green algae Halimeda macroloba (Decaisne, 1841) as an antioxidant agent from Banyak Island Aceh Singkil. IOP Conference. Series.: Earth Environmental. Science. 348 012043.
Gazali, M., Nurjanah, Zamani, N.P. (2019b). The potency of green algae Chaetomorpha crassa Agardh as antioxidant agent from the coastal of Lhok Bubon, West Aceh IOP Conference. Series.: Earth Environmental. Science. 278 012029
Gazali, M., Nurjanah., Zamani, N.P., Zuriat., & Nasution, M. A. (2020). A study on a potential bioactive compound in green seaweed Chaetomorpha antennina Kützing (1847) extract as antioxidant from the Gosong Telaga Coast, Aceh Singkil. IOP Conference. Series.: Earth Environmental. Science. 564 012058
Gazali, M., N.P. Zamani., M. Suriani., Alfitrah, R., Syafitri., R., Hanum, Z., Zurba, N., Febrina, C.D., Chermahini, S. H. (2020). Antioxidant activity of green seaweed Caulerpa racemosa (Försskal) J. Agardh from Balai Island Water, Aceh. IOP Conference. Series.: Earth Environmental. Science. IOP Conference. Series.: Earth Environmental. Science. 564 012058
Gazali, M., Nursid, M., Husni, A., Nurjanah., Zamani, N. P., Zuriat, Febrina, C. D., Zurba, N., Husin, H., & Hidayat. (2022). The effect of different drying methods on antioxidant compounds and fucoxanthin content of brown seaweed from the intertidal zone of West Aceh, Indonesia. AACL Bioflux. 15(6), 3212-3219.
Gazali, M., Jolanda, O., Husni, A., Nurjanah., Majid F.A.A., Zuriat., & Syafitri, R. (2023a). In Vitro α-Amylase and α-Glucosidase Inhibitory Activity of Green Seaweed Halimeda tuna Extract from the Coast of Lhok Bubon, Aceh. Plants. 12(2), 393. https://doi.org/10.3390/plants1202039
Gazali, M., A. Husni, Majid. F.A.A., Syafitri, R., Wahyuni, S., & Hidayat, D. (2023b). The evaluation of antioxidant action of green seaweed Boergesenia forbesii extracts. IOP Conference. Series.: Earth Environmental. Science. IOP Conference. Series.: Earth Environmental. Science. 1137 012044.
Gazali, M., Fatimah, A.N., Husni, A., Nurjanah, Zuriat, & Syafitri, R. (2024). Antioxidant and anti-arthritic activities of green seaweed Halimeda tuna methanolic extract. Squalen Bulletin Marine and Fisheries Postharvest Biotechnology. (2024) 19(1): 45-54.
Ghareeb, D. A., H. Zaatout, A. Abd-Elgwad., & Ismael, A. (2019). Phytochemical, antioxidant and anti-inflammatory screening of the egyptian Ulva lactuca methanolic extract. Pharmaceutical and Biomedical Science, 3(2), 33–38.
Ghulamahdi, M., Aziz, S. A, & Nirwan, N. (2008). Peningkatan laju pertumbuhan dan kandungan flavonoid klon daun dewa (Gynura pseudochina (L.) Dc) melalui periode pencahayaan. Indonesian Journal of Agronomy: 36(1), 40–48.
Girsang, E., Lister, I. N. E., Ginting, C. N., Bethasari, M., Amalia, A., & Widowati, W. (2020). Comparison of antiaging and antioxidant activities of protocatechuic and ferulic acids. Molecular and Cellular Biomedical Sciences, 4(2): 68-75.
Gromkowska-Kępka, K. J., Puścion-Jakubik, A., Markiewicz-Żukowska, R., & Socha, K. (2021). The impact of ultraviolet radiation on skin photoaging - review of in vitro studies. Journal of Cosmetic Dermatology, 20(11), 3427–3431. https://doi.org/10.1111/JOCD.14033
Hassan, S. M., & Ghareib, H. R. (2009). Bioactivity of Ulva lactuca L. acetone extract on germination and growth of lettuce and tomato plants. African Journal of Biotechnology, 8(16), 3832–3838.
Hoang, K. C., Tran, T. H. H., Truong, N. H., Tran, T. N. H., Le, M. H., & Le, H. C. (2022). Screening of algae collected from Nha Trang Bay, Vietnam, for potential cosmeceutical bioproducts. Vietnam Journal of Marine Science and Technology, 22(4), 415-422
Husni, A., Jeon, J. S., Um, B. H., Han, N. S., & Chung, D. (2011). Tyrosinase inhibition by water and ethanol extracts of a Far Eastern sea cucumber, Stichopus japonicus. Journal of the Science of Food and Agriculture, 91(9), 1541–1547. https://doi.org/10.1002/JSFA.4335
Husni, A., Gazali, M., Nurjanah, N., Syafitri, R., Matin, A. and Zuriat, Z. (2024) Cytotoxic Activity of Green Seaweed Halimeda tuna Methanolic Extract Against Lung Cancer Cells, Journal of Multidisciplinary Applied Natural Science. 4(1), 16-29. doi: 10.47352/jmans.2774-3047.172.
Johnson, O. O., G. A. Ayoola, G, & Adenipekun, T. (2013). Antimicrobial activity and the chemical composition of the volatile oil blend from Allium sativum (garlic clove) and Citrus reticulata (tangerine fruit). International Journal of Pharmaceutical Sciences and Drug Research, 5(4), 187-193.
Kang, H. S., Kim, H. R., Byun, D. S., Son, B. W., Nam, T. J., & Choi, J. S. (2004). Tyrosinase inhibitors isolated from the edible brown alga Ecklonia stolonifera. Pharmacal Research, 27(12), 1226–1232.
Keintjem, B. S., Wewengkang, D. S., & Fatimawali. (2019). Aktivitas penghambatan pertumbuhan mikroorganisme dari ekstrak dan fraksi alga Ulva lactuca terhadap Escherichia coli, Staphylococcus aureus, dan Candida albicans. Pharmacon: Jurnal Farmasi Indonesia, 8(2), 397–405.
Ko, D., Wang, R. F., Ozog, D., Lim, H. W., & Mohammad, T. F. (2023). Disorders of hyperpigmentation. Part II. Review of management and treatment options for hyperpigmentation. Journal of The American Academy of Dermatology, 88(2), 291–320.
Komala, P. T. H., & Husni, A. (2021). Pengaruh suhu ekstraksi, terhadap aktivitas antioksidan ekstrak metanolik Eucheuma spinosum. Jurnal Pengolahan Hasil Perikanan Indonesia, 24(1), 1–10.
Kurniasih, S. D., Pramesti, R., & Ridlo, A. (2014). Penentuan aktivitas antioksidan ekstrak rumput laut Ulva sp. dari Pantai Krakal Yogyakarta. Journal of Marine Research, 3(4): 617–626. Ko, D., Wang, R. F., Ozog, D., Lim, H. W., & Mohammad, T. F. (2023). Disorders of hyperpigmentation. Part II. Review of management and treatment options for hyperpigmentation. Journal of the American Academy of Dermatology, 88(2), 291–320. https://doi.org/10.1016/J.JAAD.2021.12.065
Lalopua, V. M. N. (2020). The yield of crude extract and fraction solvent of red algae (Kappaphycus Alvarezii Doty). Jurnal Kementerian Perindustrian Republik Indonesia, 16(1), 1–5.
Lee, S. Y., Choi, E. J., Bae, D. H., Lee, D. W., & Kim, S. (2015). Effects of 1-tetradecanol and β-sitosterol isolated from Dendropanax morbifera Lev. on skin whitening, moisturizing and preventing hair loss. Journal of The Society of Cosmetic Scientists of Korea, 41(1), 73–83.
Loho, R. E. M., Tiho, M., & Assa, Y. A. (2021). Kandungan dan aktivitas antioksidan pada rumput laut merah. Medical Scope Journal, 3(1), 113–120.
Manga, P., D. Sheyn, F., Yang, Sarangarajan, R., & Boissy, R. E. (2006). A role for tyrosinase-related protein 1 in 4-tert-butylphenol-induced toxicity in melanocytes: Implications for vitiligo. The American journal of pathology, 169(5), 1652-1662.
Maruyama, H., Kawakami, F., Lwin, T. T., Imai, M., & Shamsa, F. (2018). Biochemical characterization of ferulic acid and caffeic acid which effectively inhibit melanin synthesis via different mechanisms in B16 melanoma cells. Biological and Pharmaceutical Bulletin, 41(5), 806-810
Moulazadeh, A., Ranjbar, R., Hekmat, M., Sedaghat, F., Yousefzadi, M., & Najafipour, S. (2021). Comparison the cytotoxic effects of Ulva fasciata and Ulva lactuca on the MCF-7 and MDA-MB-231 breast cancer cell lines. Physiology and Pharmacology (Iran) Journal, 25(4), 373–383.
Mustarichie, R., Iskandar, Y., & Saptarini, N. M., (2022). Coleus atropurpureus (L) benth. leaves as a new promising drug for abscesses caused by methicillin-resistant Staphylococcus aureus and Staphylococcus aureus. Pharmacognosy Journal, 14(2), 439–443.
Namjoyan, F., Farasat, M., Alishahi, M., Jahangiri, A., & Mousavi, H. (2019). The anti-melanogenesis activities of some selected red macroalgae from northern coasts of the Persian Gulf. Iranian Journal of Pharmaceutical Research, 18(1): 383–390.
Nautiyal, A., & Wairkar, S. (2021). Management of hyperpigmentation: Current treatments and emerging therapies. Pigment Cell & Melanoma Research, 34(6), 1000–1014. https://doi.org/10.1111/PCMR.12986
Nurjanah, Abdullah. A., & Nufus, C. (2018). Karakteristik sediaan garam Ulva lactuca dari perairan sekotong Nusa Tenggara Barat bagi pasien hipertensi. Jurnal Pengolahan Hasil Perikanan Indonesia, 21(1), 109-117.
Nurjanah, Jacoeb, A.M., Ramlan, & Abdullah, A. (2020). Penambahan genjer (Limnocharis flava) pada pembuatan garam rumput laut hijau untuk penderita hipertensi. Jurnal Pengolahan Hasil Perikanan Indonesia, 23(3), 459-469.
Nurjanah, Ramlan, Jacoeb, A. M., & Seulalae, A.V. (2023). Komposisi kimia tepung dan aktivitas antioksidan ekstrak Ulva lactuca dan genjer (Limnocharis flava) sebagai bahan baku pembuatan garam rumput laut. Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan, 18(1), 63-74. http://dx.doi.org/10.15578/jpbkp.v18i1.931
Nurjanah, Jacoeb, A. M., Abdullah, A., Priyanto, J. A., Nurdin, N. M., & Seulalae, A. V. (2023). Study of Actinotrichia fragilis Indonesian red seaweed as raw material for healthy salt. Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology, 18(1), 1-8. https://doi.org/ 10.15578/squalen.753
Nurjanah, Nurilmala, M., Alfarizi, S., Rochima, E., Wahyuni, D. S., & Seulalae, A. V. (2024, June 6). Characterization of seaweed healthy salt from Indonesian Ulva lactuca and Chaetomorpha sp. flour [Conference session]. 6th EMBRIO International Symposium: “Ocean for Prosperity: Sustainably Use of the Ocean Resources for Economic Growth, Improvement of Livelihoods, and Preserve its Ocean Ecosystem Health” (EIS 2023). https://doi.org/10.1051/bioconf/202411209002
Nusaibah, Muhammad, T., Pangestika, W., Siregar, A.N., & Utami, K.D. (2023). Karakteristik serum wajah dari sediaan filtrat rumput laut Eucheuma cottonii dan Ulva lactuca. Jurnal Pengolahan Hasil Perikanan Indonesia, 26(3), 545-559. http://dx.doi.org/10.17844/jphpi.v26i3.46874
Pangaribuan, L. (2017). Efek samping kosmetik dan penangananya bagi kaum perempuan. Jurnal Keluarga Sehat Sejahtera, 15(2), 20–28.
Pannindriya, P., Safithri, M., & Tarman, K. (2021). Analisis in silico senyawa aktif Spirulina platensis sebagai inhibitor tirosinase. Jurnal Pengolahan Hasil Perikanan Indonesia. 24(1): 70-77. https://doi.org/10.17844/jphpi.v24i1.33122
Pappou, S., Dardavila, M. M., Savvidou, M. G.V, Louli, K., Magoulas, & Voutsas, E. (2022). Extraction of bioactive compounds from Ulva lactuca. Applied Sciences, 12(4), 1-17.
Phasha, V., Senabe, J., Ndzotoyi, P., Okole, B., Fouche, G., & Chuturgoon, A. (2022). Review on the use of kojic acid – a skin-lightening ingredient. Cosmetics, 9(64): 1-11
Prasedya, E. S., Martyasari, N. W., Apriani, R., Mayshara, S., Fanani, R. A., & Sunarpi, H. (2019). Antioxidant activity of Ulva lactuca L. from different coastal locations of Lombok Island, Indonesia. AIP Conference Proceedings, 2199, 1-8
Prasetyo, B. F. (2021). Uji aktivitas antioksidan dan daya hambat enzim tirosinase ekstrak etanol Azolla filiculoides Lam. Jurnal Sains Farmasi & Klinis, 8(1): 53-59.
Purwaningsih, S., & Deskawati, E. (2020). Karakteristik dan aktivitas antioksidan rumput laut Gracilaria sp. asal Banten. Jurnal Pengolahan Hasil Perikanan Indonesia, 23(3), 503–512.
Rahayu, S. T., Sari, R. Y., Mahayasih, M. W., Utami, T. P., & Eden, Y. (2023). Penentuan sun protection factor dan antioksidan ekstrak alga hijau (Ulva reticulata forsskal) sebagai tabir surya dengan spektrofotometer UV-VIS. Archives Pharmacia, 5(1), 50–62.
Rawa, A., M. S., Hassan, Z., Murugaiyah, V., Nogawa, T., & Wahab, H. A. (2019). Anti-cholinesterase potential of diverse botanical families from Malaysia: Evaluation of crude extracts and fractions from liquid-liquid extraction and acid-base fractionation. Journal of Ethnopharmacology, 245, 112160. https://doi.org/10.1016/J.JEP.2019.112160
Saeed, A. M., Abotaleb, S., Alam, N., El-Mehalawy, A., & Gheda, S. (2020). In vitro assessment of antimicrobial, antioxidant and anticancer activities of some marine macroalgae. Egyptian Journal of Botany, 60(1), 81–96.
Safithri, M., Setyaningsih, I., Tarman, K., Suptijah, P., Yuhendri, V. M., & Meydia. (2018). Potensi kolagen teripang emas sebagai inhibitor tirosinase. Jurnal Pengolahan Hasil Perairan Indonesia. 21(2): 295-303. https://doi.org/10.17844/jphpi.v21i2.23085
Sari, D. M., Anwar, E., & Arifianti, A. E. (2019). Antioxidant and tyrosinase inhibitor activities of ethanol extracts of brown seaweed (Turbinaria conoides) as lightening ingredient. Pharmacognosy Journal, 11(2), 379–382.
Seulalae, A. V., Prangdimurti, E., Adawiyah, D. R., & Nurjanah, N. (2023). Evaluasi tingkat keasinan relatif dan profil sensori garam rumput laut menggunakan metode magnitude estimation dan rate-all-that-apply (RATA). Jurnal Pengolahan Hasil Perikanan Indonesia, 26(1), 54–66. https://doi.org/10.17844/jphpi.v26i1.44466
Sihono, Sinurat, E., Fateha, Supriyanto, A., Suryaningrum, T. D., Nurhayati, Fransiska, D., Utomo, B. S. B., Subaryono, Sedayu, B.B., Waryanto, Nurjanah, Ramadhan, W., Fadillah, H.M., & Muzayyanah, A. L. (2023). Optimasi formula nori-like product dari Ulva spp., Gracilaria sp., dan gliserol menggunakan metode mixture design. Jurnal Pengolahan Hasil Perikanan Indonesia, 26(3), 433-447. http://dx.doi.org/10.17844/jphpi.v26i3.48337
Suryanto, E., & Momuat, L. I. (2017). Isolasi dan aktivitas antioksidan fraksi dari ekstrak tongkol jagung. Agritech, 37(2), 139–147
Tamat, S. R., Wikanta, T., & Maulina, L. S. (2007). Aktivitas antioksidan dan toksisitas senyawa bioaktif dari ekstrak rumput laut hijau Ulva reticulata Forsskal. Jurnal Ilmu Kefarmasian Indonesia, 5(1), 31–36.
Uchida, R., Ishikawa, S., & Tomoda, H. (2014). Inhibjition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol. Acta Pharmaceutica Sinica B, 4(2), 141–145. https://doi.org/10.1016/J.APSB.2013.12.008
Valentine, G., Sumardianto, & Wijayanti, I. (2020). Karakteristik nori dari rumput laut Ulva lactuca dan Gelidium sp. Jurnal Pengolahan Hasil Perikanan Indonesia, 23(2): 295-302. https://doi.org/10.17844/jphpi.v23i2.32340
Wang, R. F., Ko, D., Friedman, B. J., Lim, H. W., & Mohammad, T. F. (2023). Disorders of hyperpigmentation. Part I. Pathogenesis and clinical features of common pigmentary disorders. Journal of the American Academy of Dermatology, 88(2), 271–288. https://doi.org/10.1016/J.JAAD.2022.01.051
Wen, Y., Zhang, Y., Zhang, X., Wang, L., Pan, Q., Bai, Q., & Chai, W. (2023). Inhibition of albendazole and 2‐(2‐aminophenyl)‐1H‐benzimidazole against tyrosinase: mechanism, structure‐activity relationship, and anti‐browning effect. Journal of the Science of Food and Agriculture, 103(2), 2824
Windyaswari, A. S., Elfahmi, F., Faramayuda, S., Riyanti, O. M., Luthfi, I. P., Ayu, N. T. Pratiwi, M., Husna, K. H. N., & Maghfira, R. (2019). Profil fitokimia selada laut (Ulva lactuca) dan mikro alga filamen (Spirogyra sp) sebagai bahan alam bahari potensial dari perairan indonesia. Kartika: Jurnal Ilmiah Farmasi, 7(2), 88-101
Yoga, W. K., & Komalasari, H. (2022). Potensi alga hijau (Caulerpa racemosa) sebagai sumber antioksidan alami. Jurnal Teknologi dan Mutu Pangan, 1(1): 15–18.
Yu, Q., & Fan, L. (2021). Understanding the combined effect and inhibition mechanism of 4-hydroxycinnamic acid and ferulic acid as tyrosinase inhibitors. Food Chemistry, 352, 1-11
Yu, Q., Fan, L. & Ding, Z. (2022). The inhibition mechanisms between asparagus polyphenols after hydrothermal treatment and tyrosinase: A circular dichroism spectrum, fluorescence, and molecular docking. Food Bioscience, 48, 1-11
Zhang, J. P., Chen, Q. X., Song, K. K., & Xie, J. J. (2006). Inhibitory effects of salicylic acid family compounds on the diphenolase activity of mushroom tyrosinase. Food Chemistry, 95(4), 57.
Amri, E., Dharma, A., Armaini., & Tjong, D. H. (2017). Potency of microalgae as tyrosinase inhibitor. Journal of Pharmaceutical Biological and Chemical Sciences, 8(4), 577-581.
Arbi, B., Ma’ruf, W. F., & Romadhon, R. (2016). Aktivitas senyawa bioaktif selada laut (Ulva lactuca) sebagai antioksidan pada minyak ikan. Indonesian Journal of Fisheries Science and Technology (IJFST) Saintek Perikanan, 12(1), 12–18.
Arguelles, D. E., & Sapin, A. B. (2020). Bioactive properties of Sargassum siliquosum j. Agardh (fucales, ochrophyta) and its potential as source of skin-lightening active ingredient for cosmetic application. Journal of Applied Pharmaceutical Science, 10(7), 51–58.
Arguelles, E. D. L. R. (2021). Evaluation of antioxidant capacity, tyrosinase inhibition, and antibacterial activities of brown seaweed, Sargassum ilicifolium (Turner) C. Agardh 1820 for cosmeceutical application. Journal of Fisheries and Environment, 45(1): 64–77.
Arifianti, A. E., Anwar, E., & Nurjanah. (2017). Aktivitas penghambatan tirosinase dan antioksidan serbuk rumput laut dari Sargassum plagiophyllum segar dan kering. Jurnal Pengolahan Hasil Perikanan Indonesia, 20(3), 488–493.
Ashooriha, M., Khoshneviszadeh, M., Rafiei, A., Kardan, M., Yazdian-Robati, R., & Emami, S. (2020). Kojic acid–natural product conjugates as mushroom tyrosinase inhibitors. European Journal of Medicinal Chemistry, 201(1), 1-13
Aslan, E., Aksu, A., Korkmaz, N. E., Taskin, O. S., & Caglar, N. B. (2019). Monitoring the antioxidant activities by extracting the polyphenolic contents of algae collected from the bosphorus. Marine Pollution Bulletin, 141, 313–317.
Baek, S. H., Cao, L., Jeong, S. J., Kim, H. R., Nam, T. J., & Lee, S.G. (2021). The comparison of total phenolics, total antioxidant, and anti-tyrosinase activities of korean Sargassum species. Journal of Food Quality, 2012: 1-7
Badan Pengawas Obat dan Makanan Republik Indonesia (BPOM-RI). 2015. Peraturan Kepala Badan Pengawas Obat dan Makanan Republik Indonesia Nomor 18 Tahun 2015. Diakses pada Tanggal 12 Februari 2024 pada link: https://standar-otskk.pom.go.id/storage/uploads/9e774c2d-b936-4643-9ecf-30f9370d3f13/Perka-BPOM-No.-18-tahun-2015.pdf
Chan, Y. Y., Kim, K. H., & Cheah, S. H. (2011). Inhibitory effects of Sargassum polycystum on tyrosinase activity and melanin formation in b16f10 murine melanoma cells. Journal of Ethnopharmacology, 137(3), 1183–1188.
Chang, C., Yang, M.H., Wen, H. M., & Chern, J. C. (2002). Estimation of total flavonoid content in propolis by two complementary colorimetric methods. Journal of Food and Drug Analysis, 10(3), 178–182.
Cho, M. (2010). The antioxidant properties of ethanol extracts and their solvent-partitioned fractions from various green seaweeds. Journal of Medicinal Food, 13(5): 1232–1239.
Choosuwan, P., Praiboon, J., Boonpisuttinant, K., Klomjit, A., Muangmai, Ruangchuay, N., & Chirapart, A. (2023). Inhibitory Effects of Caulerpa racemosa, Ulva intestinalis, and Lobophora challengeriae on Tyrosinase Activity and α-MSH-Induced Melanogenesis in B16F10 Melanoma Cells. Life, 13(4), 3-16. https://doi.org/10.3390/LIFE13040934
Cui, Y., Hu, Y. H., Yu, F., Zheng, L. S., Chen, Q., Chen, X., & Q, Wang. (2017). Inhibition kinetics and molecular simulation of p-substituted cinnamic acid derivatives on tyrosinase. International Journal of Biological Macromolecules, 95: 1289–1297.
Di Petrillo, A., González-Paramás, A. M., Era, B. R., Medda, F., Pintus, C., Santos-Buelga., & Fais, A. (2016). Tyrosinase inhibition and antioxidant properties of asphodelus microcarpus extracts. BMC Complementary and Alternative Medicine, 16(1), 1-9
Dolorosa, M. T. (2019). Tyrosinase inhibitory activity of Sargassum plagyophyllum and Eucheuma cottonii methanol extracts. IOP Conference Series: Earth and Environmental Science, 278(1), 1–7.
Farasat, M., Khavari-Nejad, R. A., Nabavi, S. M. B., & Namjooyan, F. (2014). Antioxidant activity, total phenolics and flavonoid contents of some edible green seaweeds from Northern Coasts of The Persian Gulf. Iranian Journal of Pharmaceutical Research; 13(1): 163-170
Fathy, S. A., Mohamed, M. R., Emam, M. A., Mohamed, S. S., Ghareeb, D. A., Elgohary, S. A., & Abd-El Megeed, D. F. (2019). Therapeutic efficacy of seaweed extract (Ulva fasciata delile) against invasive candidiasis in mice. Tropical Biomedicine, 36(4): 972-986.
Fitri, A. C. K., & Proborini, W. D. (2018). Analisa komposisi minyak atsiri kulit jeruk manis hasil ekstraksi metode microwave hydrodiffusion and gravity dengan GC-MS. Jurnal Reka Buana, 3(1), 53-58.
Furi, M., Alfatma, A., Dona, R., Fernando, A., Aryani, F., Utami, R., & Octaviani, M. (2022). Uji inhibitor enzim tirosinase ekstrak dan fraksi daun kedabu (Sonneratia ovata backer) secara in vitro. Jurnal Ilmiah Manuntung, 8(2), 201-214.
Gazali, M., Nurjanah., Zamani, N. P. (2018). Eksplorasi senyawa bioaktif alga cokelat Sargassum sp. Agardh sebagai antioxidant dari Pesisir Barat Aceh. Jurnal Pengolahan Hasil Perikanan Indonesia. 21(1), 167-178.
Gazali, M., Nurjanah, Zamani, N.P. (2019a). The screening of bioactive compound of the green algae Halimeda macroloba (Decaisne, 1841) as an antioxidant agent from Banyak Island Aceh Singkil. IOP Conference. Series.: Earth Environmental. Science. 348 012043.
Gazali, M., Nurjanah, Zamani, N.P. (2019b). The potency of green algae Chaetomorpha crassa Agardh as antioxidant agent from the coastal of Lhok Bubon, West Aceh IOP Conference. Series.: Earth Environmental. Science. 278 012029
Gazali, M., Nurjanah., Zamani, N.P., Zuriat., & Nasution, M. A. (2020). A study on a potential bioactive compound in green seaweed Chaetomorpha antennina Kützing (1847) extract as antioxidant from the Gosong Telaga Coast, Aceh Singkil. IOP Conference. Series.: Earth Environmental. Science. 564 012058
Gazali, M., N.P. Zamani., M. Suriani., Alfitrah, R., Syafitri., R., Hanum, Z., Zurba, N., Febrina, C.D., Chermahini, S. H. (2020). Antioxidant activity of green seaweed Caulerpa racemosa (Försskal) J. Agardh from Balai Island Water, Aceh. IOP Conference. Series.: Earth Environmental. Science. IOP Conference. Series.: Earth Environmental. Science. 564 012058
Gazali, M., Nursid, M., Husni, A., Nurjanah., Zamani, N. P., Zuriat, Febrina, C. D., Zurba, N., Husin, H., & Hidayat. (2022). The effect of different drying methods on antioxidant compounds and fucoxanthin content of brown seaweed from the intertidal zone of West Aceh, Indonesia. AACL Bioflux. 15(6), 3212-3219.
Gazali, M., Jolanda, O., Husni, A., Nurjanah., Majid F.A.A., Zuriat., & Syafitri, R. (2023a). In Vitro α-Amylase and α-Glucosidase Inhibitory Activity of Green Seaweed Halimeda tuna Extract from the Coast of Lhok Bubon, Aceh. Plants. 12(2), 393. https://doi.org/10.3390/plants1202039
Gazali, M., A. Husni, Majid. F.A.A., Syafitri, R., Wahyuni, S., & Hidayat, D. (2023b). The evaluation of antioxidant action of green seaweed Boergesenia forbesii extracts. IOP Conference. Series.: Earth Environmental. Science. IOP Conference. Series.: Earth Environmental. Science. 1137 012044.
Gazali, M., Fatimah, A.N., Husni, A., Nurjanah, Zuriat, & Syafitri, R. (2024). Antioxidant and anti-arthritic activities of green seaweed Halimeda tuna methanolic extract. Squalen Bulletin Marine and Fisheries Postharvest Biotechnology. (2024) 19(1): 45-54.
Ghareeb, D. A., H. Zaatout, A. Abd-Elgwad., & Ismael, A. (2019). Phytochemical, antioxidant and anti-inflammatory screening of the egyptian Ulva lactuca methanolic extract. Pharmaceutical and Biomedical Science, 3(2), 33–38.
Ghulamahdi, M., Aziz, S. A, & Nirwan, N. (2008). Peningkatan laju pertumbuhan dan kandungan flavonoid klon daun dewa (Gynura pseudochina (L.) Dc) melalui periode pencahayaan. Indonesian Journal of Agronomy: 36(1), 40–48.
Girsang, E., Lister, I. N. E., Ginting, C. N., Bethasari, M., Amalia, A., & Widowati, W. (2020). Comparison of antiaging and antioxidant activities of protocatechuic and ferulic acids. Molecular and Cellular Biomedical Sciences, 4(2): 68-75.
Gromkowska-Kępka, K. J., Puścion-Jakubik, A., Markiewicz-Żukowska, R., & Socha, K. (2021). The impact of ultraviolet radiation on skin photoaging - review of in vitro studies. Journal of Cosmetic Dermatology, 20(11), 3427–3431. https://doi.org/10.1111/JOCD.14033
Hassan, S. M., & Ghareib, H. R. (2009). Bioactivity of Ulva lactuca L. acetone extract on germination and growth of lettuce and tomato plants. African Journal of Biotechnology, 8(16), 3832–3838.
Hoang, K. C., Tran, T. H. H., Truong, N. H., Tran, T. N. H., Le, M. H., & Le, H. C. (2022). Screening of algae collected from Nha Trang Bay, Vietnam, for potential cosmeceutical bioproducts. Vietnam Journal of Marine Science and Technology, 22(4), 415-422
Husni, A., Jeon, J. S., Um, B. H., Han, N. S., & Chung, D. (2011). Tyrosinase inhibition by water and ethanol extracts of a Far Eastern sea cucumber, Stichopus japonicus. Journal of the Science of Food and Agriculture, 91(9), 1541–1547. https://doi.org/10.1002/JSFA.4335
Husni, A., Gazali, M., Nurjanah, N., Syafitri, R., Matin, A. and Zuriat, Z. (2024) Cytotoxic Activity of Green Seaweed Halimeda tuna Methanolic Extract Against Lung Cancer Cells, Journal of Multidisciplinary Applied Natural Science. 4(1), 16-29. doi: 10.47352/jmans.2774-3047.172.
Johnson, O. O., G. A. Ayoola, G, & Adenipekun, T. (2013). Antimicrobial activity and the chemical composition of the volatile oil blend from Allium sativum (garlic clove) and Citrus reticulata (tangerine fruit). International Journal of Pharmaceutical Sciences and Drug Research, 5(4), 187-193.
Kang, H. S., Kim, H. R., Byun, D. S., Son, B. W., Nam, T. J., & Choi, J. S. (2004). Tyrosinase inhibitors isolated from the edible brown alga Ecklonia stolonifera. Pharmacal Research, 27(12), 1226–1232.
Keintjem, B. S., Wewengkang, D. S., & Fatimawali. (2019). Aktivitas penghambatan pertumbuhan mikroorganisme dari ekstrak dan fraksi alga Ulva lactuca terhadap Escherichia coli, Staphylococcus aureus, dan Candida albicans. Pharmacon: Jurnal Farmasi Indonesia, 8(2), 397–405.
Ko, D., Wang, R. F., Ozog, D., Lim, H. W., & Mohammad, T. F. (2023). Disorders of hyperpigmentation. Part II. Review of management and treatment options for hyperpigmentation. Journal of The American Academy of Dermatology, 88(2), 291–320.
Komala, P. T. H., & Husni, A. (2021). Pengaruh suhu ekstraksi, terhadap aktivitas antioksidan ekstrak metanolik Eucheuma spinosum. Jurnal Pengolahan Hasil Perikanan Indonesia, 24(1), 1–10.
Kurniasih, S. D., Pramesti, R., & Ridlo, A. (2014). Penentuan aktivitas antioksidan ekstrak rumput laut Ulva sp. dari Pantai Krakal Yogyakarta. Journal of Marine Research, 3(4): 617–626. Ko, D., Wang, R. F., Ozog, D., Lim, H. W., & Mohammad, T. F. (2023). Disorders of hyperpigmentation. Part II. Review of management and treatment options for hyperpigmentation. Journal of the American Academy of Dermatology, 88(2), 291–320. https://doi.org/10.1016/J.JAAD.2021.12.065
Lalopua, V. M. N. (2020). The yield of crude extract and fraction solvent of red algae (Kappaphycus Alvarezii Doty). Jurnal Kementerian Perindustrian Republik Indonesia, 16(1), 1–5.
Lee, S. Y., Choi, E. J., Bae, D. H., Lee, D. W., & Kim, S. (2015). Effects of 1-tetradecanol and β-sitosterol isolated from Dendropanax morbifera Lev. on skin whitening, moisturizing and preventing hair loss. Journal of The Society of Cosmetic Scientists of Korea, 41(1), 73–83.
Loho, R. E. M., Tiho, M., & Assa, Y. A. (2021). Kandungan dan aktivitas antioksidan pada rumput laut merah. Medical Scope Journal, 3(1), 113–120.
Manga, P., D. Sheyn, F., Yang, Sarangarajan, R., & Boissy, R. E. (2006). A role for tyrosinase-related protein 1 in 4-tert-butylphenol-induced toxicity in melanocytes: Implications for vitiligo. The American journal of pathology, 169(5), 1652-1662.
Maruyama, H., Kawakami, F., Lwin, T. T., Imai, M., & Shamsa, F. (2018). Biochemical characterization of ferulic acid and caffeic acid which effectively inhibit melanin synthesis via different mechanisms in B16 melanoma cells. Biological and Pharmaceutical Bulletin, 41(5), 806-810
Moulazadeh, A., Ranjbar, R., Hekmat, M., Sedaghat, F., Yousefzadi, M., & Najafipour, S. (2021). Comparison the cytotoxic effects of Ulva fasciata and Ulva lactuca on the MCF-7 and MDA-MB-231 breast cancer cell lines. Physiology and Pharmacology (Iran) Journal, 25(4), 373–383.
Mustarichie, R., Iskandar, Y., & Saptarini, N. M., (2022). Coleus atropurpureus (L) benth. leaves as a new promising drug for abscesses caused by methicillin-resistant Staphylococcus aureus and Staphylococcus aureus. Pharmacognosy Journal, 14(2), 439–443.
Namjoyan, F., Farasat, M., Alishahi, M., Jahangiri, A., & Mousavi, H. (2019). The anti-melanogenesis activities of some selected red macroalgae from northern coasts of the Persian Gulf. Iranian Journal of Pharmaceutical Research, 18(1): 383–390.
Nautiyal, A., & Wairkar, S. (2021). Management of hyperpigmentation: Current treatments and emerging therapies. Pigment Cell & Melanoma Research, 34(6), 1000–1014. https://doi.org/10.1111/PCMR.12986
Nurjanah, Abdullah. A., & Nufus, C. (2018). Karakteristik sediaan garam Ulva lactuca dari perairan sekotong Nusa Tenggara Barat bagi pasien hipertensi. Jurnal Pengolahan Hasil Perikanan Indonesia, 21(1), 109-117.
Nurjanah, Jacoeb, A.M., Ramlan, & Abdullah, A. (2020). Penambahan genjer (Limnocharis flava) pada pembuatan garam rumput laut hijau untuk penderita hipertensi. Jurnal Pengolahan Hasil Perikanan Indonesia, 23(3), 459-469.
Nurjanah, Ramlan, Jacoeb, A. M., & Seulalae, A.V. (2023). Komposisi kimia tepung dan aktivitas antioksidan ekstrak Ulva lactuca dan genjer (Limnocharis flava) sebagai bahan baku pembuatan garam rumput laut. Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan, 18(1), 63-74. http://dx.doi.org/10.15578/jpbkp.v18i1.931
Nurjanah, Jacoeb, A. M., Abdullah, A., Priyanto, J. A., Nurdin, N. M., & Seulalae, A. V. (2023). Study of Actinotrichia fragilis Indonesian red seaweed as raw material for healthy salt. Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology, 18(1), 1-8. https://doi.org/ 10.15578/squalen.753
Nurjanah, Nurilmala, M., Alfarizi, S., Rochima, E., Wahyuni, D. S., & Seulalae, A. V. (2024, June 6). Characterization of seaweed healthy salt from Indonesian Ulva lactuca and Chaetomorpha sp. flour [Conference session]. 6th EMBRIO International Symposium: “Ocean for Prosperity: Sustainably Use of the Ocean Resources for Economic Growth, Improvement of Livelihoods, and Preserve its Ocean Ecosystem Health” (EIS 2023). https://doi.org/10.1051/bioconf/202411209002
Nusaibah, Muhammad, T., Pangestika, W., Siregar, A.N., & Utami, K.D. (2023). Karakteristik serum wajah dari sediaan filtrat rumput laut Eucheuma cottonii dan Ulva lactuca. Jurnal Pengolahan Hasil Perikanan Indonesia, 26(3), 545-559. http://dx.doi.org/10.17844/jphpi.v26i3.46874
Pangaribuan, L. (2017). Efek samping kosmetik dan penangananya bagi kaum perempuan. Jurnal Keluarga Sehat Sejahtera, 15(2), 20–28.
Pannindriya, P., Safithri, M., & Tarman, K. (2021). Analisis in silico senyawa aktif Spirulina platensis sebagai inhibitor tirosinase. Jurnal Pengolahan Hasil Perikanan Indonesia. 24(1): 70-77. https://doi.org/10.17844/jphpi.v24i1.33122
Pappou, S., Dardavila, M. M., Savvidou, M. G.V, Louli, K., Magoulas, & Voutsas, E. (2022). Extraction of bioactive compounds from Ulva lactuca. Applied Sciences, 12(4), 1-17.
Phasha, V., Senabe, J., Ndzotoyi, P., Okole, B., Fouche, G., & Chuturgoon, A. (2022). Review on the use of kojic acid – a skin-lightening ingredient. Cosmetics, 9(64): 1-11
Prasedya, E. S., Martyasari, N. W., Apriani, R., Mayshara, S., Fanani, R. A., & Sunarpi, H. (2019). Antioxidant activity of Ulva lactuca L. from different coastal locations of Lombok Island, Indonesia. AIP Conference Proceedings, 2199, 1-8
Prasetyo, B. F. (2021). Uji aktivitas antioksidan dan daya hambat enzim tirosinase ekstrak etanol Azolla filiculoides Lam. Jurnal Sains Farmasi & Klinis, 8(1): 53-59.
Purwaningsih, S., & Deskawati, E. (2020). Karakteristik dan aktivitas antioksidan rumput laut Gracilaria sp. asal Banten. Jurnal Pengolahan Hasil Perikanan Indonesia, 23(3), 503–512.
Rahayu, S. T., Sari, R. Y., Mahayasih, M. W., Utami, T. P., & Eden, Y. (2023). Penentuan sun protection factor dan antioksidan ekstrak alga hijau (Ulva reticulata forsskal) sebagai tabir surya dengan spektrofotometer UV-VIS. Archives Pharmacia, 5(1), 50–62.
Rawa, A., M. S., Hassan, Z., Murugaiyah, V., Nogawa, T., & Wahab, H. A. (2019). Anti-cholinesterase potential of diverse botanical families from Malaysia: Evaluation of crude extracts and fractions from liquid-liquid extraction and acid-base fractionation. Journal of Ethnopharmacology, 245, 112160. https://doi.org/10.1016/J.JEP.2019.112160
Saeed, A. M., Abotaleb, S., Alam, N., El-Mehalawy, A., & Gheda, S. (2020). In vitro assessment of antimicrobial, antioxidant and anticancer activities of some marine macroalgae. Egyptian Journal of Botany, 60(1), 81–96.
Safithri, M., Setyaningsih, I., Tarman, K., Suptijah, P., Yuhendri, V. M., & Meydia. (2018). Potensi kolagen teripang emas sebagai inhibitor tirosinase. Jurnal Pengolahan Hasil Perairan Indonesia. 21(2): 295-303. https://doi.org/10.17844/jphpi.v21i2.23085
Sari, D. M., Anwar, E., & Arifianti, A. E. (2019). Antioxidant and tyrosinase inhibitor activities of ethanol extracts of brown seaweed (Turbinaria conoides) as lightening ingredient. Pharmacognosy Journal, 11(2), 379–382.
Seulalae, A. V., Prangdimurti, E., Adawiyah, D. R., & Nurjanah, N. (2023). Evaluasi tingkat keasinan relatif dan profil sensori garam rumput laut menggunakan metode magnitude estimation dan rate-all-that-apply (RATA). Jurnal Pengolahan Hasil Perikanan Indonesia, 26(1), 54–66. https://doi.org/10.17844/jphpi.v26i1.44466
Sihono, Sinurat, E., Fateha, Supriyanto, A., Suryaningrum, T. D., Nurhayati, Fransiska, D., Utomo, B. S. B., Subaryono, Sedayu, B.B., Waryanto, Nurjanah, Ramadhan, W., Fadillah, H.M., & Muzayyanah, A. L. (2023). Optimasi formula nori-like product dari Ulva spp., Gracilaria sp., dan gliserol menggunakan metode mixture design. Jurnal Pengolahan Hasil Perikanan Indonesia, 26(3), 433-447. http://dx.doi.org/10.17844/jphpi.v26i3.48337
Suryanto, E., & Momuat, L. I. (2017). Isolasi dan aktivitas antioksidan fraksi dari ekstrak tongkol jagung. Agritech, 37(2), 139–147
Tamat, S. R., Wikanta, T., & Maulina, L. S. (2007). Aktivitas antioksidan dan toksisitas senyawa bioaktif dari ekstrak rumput laut hijau Ulva reticulata Forsskal. Jurnal Ilmu Kefarmasian Indonesia, 5(1), 31–36.
Uchida, R., Ishikawa, S., & Tomoda, H. (2014). Inhibjition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol. Acta Pharmaceutica Sinica B, 4(2), 141–145. https://doi.org/10.1016/J.APSB.2013.12.008
Valentine, G., Sumardianto, & Wijayanti, I. (2020). Karakteristik nori dari rumput laut Ulva lactuca dan Gelidium sp. Jurnal Pengolahan Hasil Perikanan Indonesia, 23(2): 295-302. https://doi.org/10.17844/jphpi.v23i2.32340
Wang, R. F., Ko, D., Friedman, B. J., Lim, H. W., & Mohammad, T. F. (2023). Disorders of hyperpigmentation. Part I. Pathogenesis and clinical features of common pigmentary disorders. Journal of the American Academy of Dermatology, 88(2), 271–288. https://doi.org/10.1016/J.JAAD.2022.01.051
Wen, Y., Zhang, Y., Zhang, X., Wang, L., Pan, Q., Bai, Q., & Chai, W. (2023). Inhibition of albendazole and 2‐(2‐aminophenyl)‐1H‐benzimidazole against tyrosinase: mechanism, structure‐activity relationship, and anti‐browning effect. Journal of the Science of Food and Agriculture, 103(2), 2824
Windyaswari, A. S., Elfahmi, F., Faramayuda, S., Riyanti, O. M., Luthfi, I. P., Ayu, N. T. Pratiwi, M., Husna, K. H. N., & Maghfira, R. (2019). Profil fitokimia selada laut (Ulva lactuca) dan mikro alga filamen (Spirogyra sp) sebagai bahan alam bahari potensial dari perairan indonesia. Kartika: Jurnal Ilmiah Farmasi, 7(2), 88-101
Yoga, W. K., & Komalasari, H. (2022). Potensi alga hijau (Caulerpa racemosa) sebagai sumber antioksidan alami. Jurnal Teknologi dan Mutu Pangan, 1(1): 15–18.
Yu, Q., & Fan, L. (2021). Understanding the combined effect and inhibition mechanism of 4-hydroxycinnamic acid and ferulic acid as tyrosinase inhibitors. Food Chemistry, 352, 1-11
Yu, Q., Fan, L. & Ding, Z. (2022). The inhibition mechanisms between asparagus polyphenols after hydrothermal treatment and tyrosinase: A circular dichroism spectrum, fluorescence, and molecular docking. Food Bioscience, 48, 1-11
Zhang, J. P., Chen, Q. X., Song, K. K., & Xie, J. J. (2006). Inhibitory effects of salicylic acid family compounds on the diphenolase activity of mushroom tyrosinase. Food Chemistry, 95(4), 57.
Authors
Gazali M., Suhardani M. N., Husni A., Nurjanah N., Zuriat Z., Hasanah U., & Syafitri R. (2024). Aktivitas inhibisi tirosinase ekstrak etanol rumput laut Ulva lactuca secara in vitro: In vitro tyrosinase inhibitory activity of ethanol extract of seaweed Ulva lactuca . Jurnal Pengolahan Hasil Perikanan Indonesia, 27(7). https://doi.org/10.17844/jphpi.v27i7.53399
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