Efficacy of tamarind leaf infusion (Tamarindus indica L.) as an antidiarrheal agent in mice

Ratna Kristiani Nababan; Lina Noviyanti Sutardi; Anisa Rahma; Aulia Andi Mustika

doi:10.29244/currbiomed.3.2.53

Authors

Ratna Kristiani Nababan Study Program of Veterinary Medicine, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia
Lina Noviyanti Sutardi Sub-division of Veterinary Pharmacy, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia https://orcid.org/0000-0003-3618-0544
Anisa Rahma Sub-division of Veterinary Pharmacy, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia https://orcid.org/0000-0002-2714-6013
Aulia Andi Mustika Division of Pharmacology and Toxicology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia https://orcid.org/0000-0001-8462-7537

DOI:

https://doi.org/10.29244/currbiomed.3.2.53

Keywords:

antidiarrheal, infusion, tamarind leaves, mice, intestinal protection method

Abstract

Background Bacground Tamarind (Tamarindus indica L.) is an herbal plant that is used to treat various diseases, but there has been no scientific research on the activity of tamarind leaf infusion as an antidiarrheal.

Objectives This study aimed to analyze the effectiveness of tamarind leaf infusion preparation as an antidiarrheal agent through the intestinal protection method and determine the effective concentration for providing antidiarrheal effects in mice.

Methods This study used 30 mice were divided into five groups consisting of negative control (1% Tween 80), positive control (loperamide hydrochloride), and three groups treated with tamarind leaf infusion with graded concentrations (25%, 50%, and 100%). The parameters used in the intestinal protection method were frequency of defecation, stool consistency, time of onset of diarrhea, and duration and recovery time of diarrhea.

Results The phytochemical test results of tamarind leaf infusion contained flavonoids, steroids, and terpenoids. In vivo testing of tamarind leaf infusion in mice at concentrations of 25%, 50%, and 100% demonstrated the potential antidiarrheal activity of tamarind leaf infusion.

Conclusion Tamarind leaf infusion has antidiarrheal activity, with The best effectiveness at a concentration of 50%.