Effectiveness of Malay rose apple (Syzygium malaccense) infusion as antidiarrheal in mice (Mus musculus)

Alfian  Santosa; Trioso Purnawarman; Aulia Andi Mustika; Anisa Rahma; Lina Noviyanti  Sutardi

doi:10.29244/currbiomed.2.1.21-28

Alfian Santosa Program Studi Sarjana Kedokteran Hewan, Sekolah Kedokteran Hewan dan Biomedis, IPB University, Bogor
Trioso Purnawarman Divisi Kesehatan Masyarakat Veteriner dan Epidemiologi, Sekolah Kedokteran Hewan dan Biomedis, IPB University, Bogor
Aulia Andi Mustika Divisi Farmakologi dan Toksikologi Veteriner, Sekolah Kedokteran Hewan dan Biomedis, IPB University, Bogor
Anisa Rahma Sub-divisi Farmasi, Sekolah Kedokteran Hewan dan Biomedis, IPB University, Bogor
Lina Noviyanti Sutardi Sub-divisi Farmasi, Sekolah Kedokteran Hewan dan Biomedis, IPB University, Bogor

DOI: https://doi.org/10.29244/currbiomed.2.1.21-28

Keywords: antidiarrheal, defecation, infusion, Malay rose apple fruit, mouse

Abstract

Background: Malay rose apple (Syzygium malaccense) fruit has been used for a long time as a traditional medicine for diarrhea by the community. Malay rose apple fruit contains active compounds such as flavonoids, tannins, and terpenoids and could be used as an antidiarrheal drug. Objective: This study aims to test the effectiveness of the infusion of Malay rose apple fruit as an antidiarrheal agent in mice (Mus musculus). Methods: This research uses the method of intestinal protection and intestinal transit. The experimental animals in this study were 25 mice, which were divided into 5 groups, consisting of negative control (1% Tween 80), positive control group (loperamide HCl), and treatment groups using infusion of Malay rose apple fruit at concentrations of 50%, 75%, and 100%. The parameters assessed in the intestinal protection method are the frequency of defecation and the consistency of the stool, while the intestinal transit method is the ratio of marker passages. Results: The results showed that the antidiarrheal effect occurred at all concentrations. The best concentration as an antidiarrhea is shown by infusion with a concentration of 50%. The 50% concentration group had the smallest average on defecation frequency, stool consistency, and marker passage ratio compared to the values of the other treatment groups and was significantly different (P<0.05) compared to the value in the negative control. Conclusion: It can be concluded that the antidiarrheal effect of the infusion of Malay rose apple fruit occurs at all concentrations, with the best effect at a concentration of 50%.