Urgensi Data Genomik dan Kapasitas Riset dalam Strategi Pengendalian Tuberkulosis di Indonesia
DOI:
https://doi.org/10.29244/agro-maritim.0802.1691-1695Keywords:
data, genomik, tuberkulosisAbstract
Setelah peningkatan kasus TB antara 2020 hingga 2023, Indonesia menjadi salah satu negara dengan TB resisten terbanyak di dunia. Data genomik dapat digunakan sebagai alat pemantau laju resistensi bakteri TB serta dampaknya terhadap efektivitas obat antibiotik di fasilitas kesehatan. Agar dapat mengumpulkan serta menganalisis data genomik secara optimal, kapasitas penelitian kesehatan nasional perlu diperkuat. Tidak hanya melalui pendanaan atau sumber daya manusia, penguatan kapasitas juga dilakukan melalui pengadaan alat, bahan, dan platform publikasi hasil penelitian. Tindak lanjut pengumpulan data adalah penerjemahan data menjadi program dan kebijakan yang spesifik bagi kelompok masyarakat yang disasar baik menurut strata sosial maupun ekonomi.
References
Al-Jardani, A., Al Yaquobi, F., Adikaram, C., Al Wahaibi, A., Al-Balushi, L., Al-Zadjali, S., Al Abri, B., Al-Thuhli, K., & Al-Abri, S. (2023). Genomic and geospatial epidemiology of Mycobacterium tuberculosis in Oman: first national insight using whole genome sequencing. International Journal of Infectious Diseases, 130, S4–S11. https://doi.org/10.1016/j.ijid.2023.04.001
Aslan, G. (2024). Diagnosing Tuberculosis: Traditional and New Methods Against an Old Enemy. Journal of Clinical Practice and Research, 46(5), 431–443. https://doi.org/10.14744/cpr.2024.95839
Black, A., & Dudas, G. (2024). The Applied Genomic Epidemiology Handbook. Chapman and Hall/CRC. https://doi.org/10.1201/9781003409809
BPS. (2024). Tuberculosis Incidence per 100,000 population 2021.
Cassini, A., Högberg, L. D., Plachouras, D., Quattrocchi, A., Hoxha, A., Simonsen, G. S., Colomb-Cotinat, M., Kretzschmar, M. E., Devleesschauwer, B., Cecchini, M., Ouakrim, D. A., Oliveira, T. C., Struelens, M. J., Suetens, C., Monnet, D. L., Strauss, R., Mertens, K., Struyf, T., Catry, B., … Hopkins, S. (2019). Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. The Lancet Infectious Diseases, 19(1), 56–66. https://doi.org/10.1016/S1473-3099(18)30605-4
Dartois, V. A., & Rubin, E. J. (2022). Anti-tuberculosis treatment strategies and drug development: challenges and priorities. Nature Reviews Microbiology, 20(11), 685–701. https://doi.org/10.1038/s41579-022-00731-y
Dashian, M. A., Shipulin, G. A., & Deviatkin, A. A. (2025). Genetic Susceptibility to Tuberculosis and the Utility of Polygenic Scores in Population Stratification. International Journal of Molecular Sciences, 26(19), 9544. https://doi.org/10.3390/ijms26199544
Kambli, P., Ajbani, K., Kazi, M., Sadani, M., Naik, S., Shetty, A., Tornheim, J. A., Singh, H., & Rodrigues, C. (2021). Targeted next generation sequencing directly from sputum for comprehensive genetic information on drug resistant Mycobacterium tuberculosis. Tuberculosis, 127, 102051. https://doi.org/10.1016/j.tube.2021.102051
Liyew, A. M., Clements, A. C. A., Akalu, T. Y., Gilmour, B., & Alene, K. A. (2024). Ecological-level factors associated with tuberculosis incidence and mortality: A systematic review and meta-analysis. PLOS Global Public Health, 4(10), e0003425. https://doi.org/10.1371/journal.pgph.0003425
Mboowa, G. (2025). Reimagining Tuberculosis Control in the Era of Genomics: The Case for Global Investment in Mycobacterium tuberculosis Genomic Surveillance. Pathogens, 14(10), 975. https://doi.org/10.3390/pathogens14100975
Meehan, C. J., Goig, G. A., Kohl, T. A., Verboven, L., Dippenaar, A., Ezewudo, M., Farhat, M. R., Guthrie, J. L., Laukens, K., Miotto, P., Ofori-Anyinam, B., Dreyer, V., Supply, P., Suresh, A., Utpatel, C., van Soolingen, D., Zhou, Y., Ashton, P. M., Brites, D., … Van Rie, A. (2019). Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues. Nature Reviews Microbiology, 17(9), 533–545. https://doi.org/10.1038/s41579-019-0214-5
National Academies of Sciences, Engineering, and Medicine. (2021). Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine. Palmer GH, Buckley GJ, editor. Washington (DC): National Academies Press.
Nasiri, M. J., & Venketaraman, V. (2025). Advances in Host–Pathogen Interactions in Tuberculosis: Emerging Strategies for Therapeutic Intervention. International Journal of Molecular Sciences, 26(4), 1621. https://doi.org/10.3390/ijms26041621
Nextstrain. (2026). Real-time tracking of Mycobacterium tuberculosis full genome evolution.
Pellini, A., Pramusinto, A., & Fatonie, I. (2018). Brokering Knowledge and Policy Analysis Within the Indonesian Public Sector. Dalam Knowledge, Politics and Policymaking in Indonesia (hlm. 47–64). Springer Singapore. https://doi.org/10.1007/978-981-13-0167-4_4
Saktiawati, A. M. I., & Probandari, A. (2025). Tuberculosis in Indonesia: challenges and future directions. The Lancet Respiratory Medicine, 13(8), 669–671. https://doi.org/10.1016/S2213-2600(25)00168-7
Silva, R. D. da, Farias, E. R. G. de, Graça, J. M. B. da, Pinheiro, E. M. N., & Cavalcante, E. F. de O. (2025). Approaches and results of intersectoral actions for tuberculosis control in the world: A scoping review. PLOS One, 20(6), e0326784. https://doi.org/10.1371/journal.pone.0326784
Sweeney, M. I., Carranza, C. E., & Tobin, D. M. (2025). Understanding Mycobacterium tuberculosis through its genomic diversity and evolution. PLOS Pathogens, 21(2), e1012956. https://doi.org/10.1371/journal.ppat.1012956
Varghese, B., Supply, P., Shoukri, M., Allix-Beguec, C., Memish, Z., Abuljadayel, N., Al-Hakeem, R., AlRabiah, F., & Al-Hajoj, S. (2013). Tuberculosis Transmission among Immigrants and Autochthonous Populations of the Eastern Province of Saudi Arabia. PLoS ONE, 8(10), e77635. https://doi.org/10.1371/journal.pone.0077635
Wee, B. A., Muloi, D. M., & van Bunnik, B. A. D. (2020). Quantifying the transmission of antimicrobial resistance at the human and livestock interface with genomics. Clinical Microbiology and Infection, 26(12), 1612–1616. https://doi.org/10.1016/j.cmi.2020.09.019
WHO. (2023). Use of targeted next-generation sequencing to detect drug-resistant tuberculosis. World Health Organization.
WHO. (2024). Global Tuberculosis Report 2024.
WHO. (2025). Health researchers in full-time equivalent as a proportion of all researchers.
Yanika, G., Alamanda, C. N. C., & Rachman, R. W. (2024). Comparison of Molecular Testing Methods in Detecting Drug Resistance Tuberculosis. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, 31(1), 88–94. https://doi.org/10.24293/ijcpml.v31i1.2295
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