The effect of sea grape (Caulerpa racemosa) powdered drink on oxidative stress and inflammation in diet-induced obesity rat models
Pengaruh minuman bubuk anggur laut (Caulerpa racemosa) terhadap stres oksidatif dan inflamasi pada model tikus obesitas yang diinduksi diet
DOI:
https://doi.org/10.17844/ms5t6f55Keywords:
Beta-oxidation, MDA, Obesity, power drink, TNF-αAbstract
The increasing incidence of obesity is a significant public health concern. The accumulation of excessive fat in obese individuals leads to an increase in beta-oxidation and esterification, which in turn causes inflammation and oxidative stress, eventually leading to cell death in the liver. This study aimed to examine the potential of a sea grape powder drink (SGPD) derived from Caulerpa racemosa in mitigating inflammation and oxidative stress in the livers of obese rats. This study employed an in vivo research design utilizing a complete randomized design (CRD) with 24 male Wistar rats weighing 150 – 250 g. The rats were divided into six groups, designated as follows: Standard Ration (SR), high-fat ration (HFR) + CMC, HFR + Orlistat 10.8 mg/kg, HFR + SGPD 1 g, HFR + SGPD 1.5 g, and HFR + SGPD 2 g. The results showed that the HFR + SGPD group exhibited the most pronounced obesity. The HFR + SGPD group administered a 2 g dose exhibited a reduction in TNF-α levels comparable to that of the RTL + Orlistat group (P < 0.05). Immunohistochemistry of TNF-α in rat liver elucidated the effect of SGPD on TNF-α-induced liver inflammation. Nevertheless, the effect of SGPD on superoxide dismutase (SOD) and malondialdehyde (MDA) showed only a tendency toward improvement across various treatment groups. The study concluded that SGPD can mitigate liver inflammation in obese rats. SGPD has antioxidant potential, making it a promising therapeutic alternative for obesity.
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Copyright (c) 2026 Dwi Santy Damayati, Evy Damayanthi, Hadi Riyadi, I Wayan Teguh Wibawan, Ekowati Handharyani, Ainulyakin Imlani, Caddoumy Zahrel Ben, Fahri Sinulingga
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