ISWANTINI, DYAH, SILITONGARHOITO FROISTA, ELIZABETH MARTATILOFA, and DARUSMANLATIFAH KOSIM. “<strong><em><span style="font-size:9pt;line-height:115%;">Zingiber cassumunar</span></em><span style="font-size:9pt;line-height:115%;"> Roxb. (<em>Bangle</em>)<em>, Guazuma ulmifolia</em> Lamk.<em> </em>(<em>Jati belanda</em>), and<em> Murraya Paniculata </em>(<em>Kemuning</em>)<em> </em>have Been Used As Slimming Agents in <em>jamu</em>. A Few Researches Have Performed Studies on Their Potency As Antiobesity. The Aim of This Research Was to Investigate the Potency of <em>Z. Cassumunar </em>rhizome,<em> G. ulmifolia,</em> and <em>M. Paniculata </em>leaf Extracts As Antiobesity Agent Based on <em>in vitro</em> Inhibition Activity of the Extracts on Pancreatic Lipase Activity. In This Research, Water Content Determination, Phytochemical Assay, Toxicity Assay and <em>in Vitro </em>assay of Inhibition Activity on Pancreatic Lipase Were Performed Toward Single and Mixture Extracts of <em>Z. Cassumunar, G. Ulmifolia, </em>and<em> M. paniculata</em> Resulted by Water, Ethanol, and Saponin extractions<em>.</em> The Results Indicated That 100 Ppm of Ethanol Extraction of <em>Z. Cassumunar </em>had Highest Inhibition Effect on the Activity of Pancreatic Lipase (29.17%), Followed by 100 Ppm of Water Extraction of <em>M. paniculata<span>  </span></em>(25.66%), 60 Ppm of Ethanol Extraction of <em>G. ulmifolia</em> leaves<em> </em>(25.13%) and Ethanol Extraction Mixture of <em>Z. cassumunar</em>, <em>G. ulmifolia,</em> and <em>M. Paniculata </em><span> </span>leaves With Ratio of 25:25:25 (21.58%). These Inhibition Effects Were Higher Than Inhibitory Effect of 100 Ppm of Xenical®/orlistat As the Positive Control, With the Inhibition Value of 17.53%. Saponin Crude Extracts Had Lower Inhibitory Effect Than the Other Extractions. It Was Suggested That Ethanol Extraction of <em>Z. Cassumunar, </em>and <em>G. Ulmifolia </em>and<em> </em>water Extraction of <em>M. Paniculata </em>had Potency As Antiobesity agent</span></Strong&gt;”. HAYATI Journal of Biosciences 18, no. 1 (1): 6. Accessed May 4, 2024. https://journal.ipb.ac.id/index.php/hayati/article/view/%3Cstrong%3E%3Cem%3E%3Cspan%20style%3D%22font-size%3A9pt%3Bline-height%3A115%25%3B%22%3EZingiber%20cassumunar%3C%2Fspan%3E%3C%2Fem%3E%3Cspan%20style%3D%22font-size%3A9pt%3Bline-height%3A115%25%3B%22%3E%20Roxb.%20%28%3Cem%3EBangle%3C%2Fem%3E%29%3Cem%3E%2C%20Guazuma%20ulmifolia%3C%2Fem%3E%20Lamk.%3Cem%3E%20%3C%2Fem%3E%28%3Cem%3EJati%20belanda%3C%2Fem%3E%29%2C%20and%3Cem%3E%20Murraya%20paniculata%20%3C%2Fem%3E%28%3Cem%3EKemuning%3C%2Fem%3E%29%3Cem%3E%20%3C%2Fem%3Ehave%20been%20used%20as%20slimming%20agents%20in%20%3Cem%3Ejamu%3C%2Fem%3E.%20A%20few%20researches%20have%20performed%20studies%20on%20their%20potency%20as%20antiobesity.%20The%20aim%20of%20this%20research%20was%20to%20investigate%20the%20potency%20of%20%3Cem%3EZ.%20cassumunar%20%3C%2Fem%3Erhizome%2C%3Cem%3E%20G.%20ulmifolia%2C%3C%2Fem%3E%20and%20%3Cem%3EM.%20paniculata%20%3C%2Fem%3Eleaf%20extracts%20as%20antiobesity%20agent%20based%20on%20%3Cem%3Ein%20vitro%3C%2Fem%3E%20inhibition%20activity%20of%20the%20extracts%20on%20pancreatic%20lipase%20activity.%20In%20this%20research%2C%20water%20content%20determination%2C%20phytochemical%20assay%2C%20toxicity%20assay%20and%20%3Cem%3Ein%20vitro%20%3C%2Fem%3Eassay%20of%20inhibition%20activity%20on%20pancreatic%20lipase%20were%20performed%20toward%20single%20and%20mixture%20extracts%20of%20%3Cem%3EZ.%20cassumunar%2C%20G.%20ulmifolia%2C%20%3C%2Fem%3Eand%3Cem%3E%20M.%20paniculata%3C%2Fem%3E%20resulted%20by%20water%2C%20ethanol%2C%20and%20saponin%20extractions%3Cem%3E.%3C%2Fem%3E%20The%20results%20indicated%20that%20100%20ppm%20of%20ethanol%20extraction%20of%20%3Cem%3EZ.%20cassumunar%20%3C%2Fem%3Ehad%20highest%20inhibition%20effect%20on%20the%20activity%20of%20pancreatic%20lipase%20%2829.17%25%29%2C%20followed%20by%20100%20ppm%20of%20water%20extraction%20of%20%3Cem%3EM.%20paniculata%3Cspan%3E%C2%A0%20%3C%2Fspan%3E%3C%2Fem%3E%2825.66%25%29%2C%2060%20ppm%20of%20ethanol%20extraction%20of%20%3Cem%3EG.%20ulmifolia%3C%2Fem%3E%20leaves%3Cem%3E%20%3C%2Fem%3E%2825.13%25%29%20and%20ethanol%20extraction%20mixture%20of%20%3Cem%3EZ.%20cassumunar%3C%2Fem%3E%2C%20%3Cem%3EG.%20ulmifolia%2C%3C%2Fem%3E%20and%20%3Cem%3EM.%20paniculata%20%3C%2Fem%3E%3Cspan%3E%C2%A0%3C%2Fspan%3Eleaves%20with%20ratio%20of%2025%3A25%3A25%20%2821.58%25%29.%20These%20inhibition%20effects%20were%20higher%20than%20inhibitory%20effect%20of%20100%20ppm%20of%20Xenical%C2%AE%2Forlistat%20as%20the%20positive%20control%2C%20with%20the%20inhibition%20value%20of%2017.53%25.%20Saponin%20crude%20extracts%20had%20lower%20inhibitory%20effect%20than%20the%20other%20extractions.%20It%20was%20suggested%20that%20ethanol%20extraction%20of%20%3Cem%3EZ.%20cassumunar%2C%20%3C%2Fem%3Eand%20%3Cem%3EG.%20ulmifolia%20%3C%2Fem%3Eand%3Cem%3E%20%3C%2Fem%3Ewater%20extraction%20of%20%3Cem%3EM.%20paniculata%20%3C%2Fem%3Ehad%20potency%20as%20antiobesity%20agent%3C%2Fspan%3E%3C%2Fstrong%3E.