@article{Bahar_Wilffert_Harapan_Nainu_2021, title={Inflammation-mediated Phenoconversion: A Potential Threat to COVID-19 Pharmacotherapy}, volume={28}, url={https://journal.ipb.ac.id/index.php/hayati/article/view/35303}, DOI={10.4308/hjb.28.1.54}, abstractNote={<p>One of the important hallmarks of coronavirus disease 2019 (COVID-19) is the existence of severe inflammatory responses. Many reports indicated that inflammatory mediators might suppress the biological functions of some drug metabolizing enzymes and transporters, and therefore result in a transient mismatch between their genotype and phenotype expressions, a phenomenon which is called phenoconversion. The incidence might be clinically relevant to the COVID-19 patients with comorbidities. The patients are treated with multiple drugs that are prone to be altered pharmacokinetically by inflammation-mediated phenoconversion, leading to the modification of their effectiveness and safety. In this review, we discuss the regulation of inflammatory responses during COVID-19 infection and the evidence as well as potential mechanisms of inflammation-mediated phenoconversion. We also provide possible clinical implications of such phenoconversion events as a potential threat in the management of COVID-19 patients.</p&gt;}, number={1}, journal={HAYATI Journal of Biosciences}, author={BaharMuh. Akbar and WilffertBob and HarapanHarapan and NainuFirzan}, year={2021}, month={Jan.}, pages={54} }