Return to Article Details <strong><em><span style="font-size:9pt;line-height:115%;">Zingiber cassumunar</span></em><span style="font-size:9pt;line-height:115%;"> Roxb. (<em>Bangle</em>)<em>, Guazuma ulmifolia</em> Lamk.<em> </em>(<em>Jati belanda</em>), and<em> Murraya paniculata </em>(<em>Kemuning</em>)<em> </em>have been used as slimming agents in <em>jamu</em>. A few researches have performed studies on their potency as antiobesity. The aim of this research was to investigate the potency of <em>Z. cassumunar </em>rhizome,<em> G. ulmifolia,</em> and <em>M. paniculata </em>leaf extracts as antiobesity agent based on <em>in vitro</em> inhibition activity of the extracts on pancreatic lipase activity. In this research, water content determination, phytochemical assay, toxicity assay and <em>in vitro </em>assay of inhibition activity on pancreatic lipase were performed toward single and mixture extracts of <em>Z. cassumunar, G. ulmifolia, </em>and<em> M. paniculata</em> resulted by water, ethanol, and saponin extractions<em>.</em> The results indicated that 100 ppm of ethanol extraction of <em>Z. cassumunar </em>had highest inhibition effect on the activity of pancreatic lipase (29.17%), followed by 100 ppm of water extraction of <em>M. paniculata<span>  </span></em>(25.66%), 60 ppm of ethanol extraction of <em>G. ulmifolia</em> leaves<em> </em>(25.13%) and ethanol extraction mixture of <em>Z. cassumunar</em>, <em>G. ulmifolia,</em> and <em>M. paniculata </em><span> </span>leaves with ratio of 25:25:25 (21.58%). These inhibition effects were higher than inhibitory effect of 100 ppm of Xenical®/orlistat as the positive control, with the inhibition value of 17.53%. Saponin crude extracts had lower inhibitory effect than the other extractions. It was suggested that ethanol extraction of <em>Z. cassumunar, </em>and <em>G. ulmifolia </em>and<em> </em>water extraction of <em>M. paniculata </em>had potency as antiobesity agent</span></strong> Download Download PDF