Proteogenomics: New Emerging Technology

  • Wasim Sajjad Key Laboratory of Petroleum Resources, Gansu Province/Key Laboratory of Petroleum Resources Research, Institute of Geology and Geophysics, Chinese Academy of Sciences, Lanzhou, PR China University of Chinese Academy of Sciences, Beijing, PR China
  • Muhammad Rafiq Department of Microbiology, Faculty of Biological Sciences, Quaid-I-Azam University, Islamabad, Pakistan
  • Barkat Ali Department of Microbiology, Faculty of Biological Sciences, Quaid-I-Azam University, Islamabad, Pakistan
  • Muhammad Hayat Department of Microbiology, Faculty of Biological Sciences, Quaid-I-Azam University, Islamabad, Pakistan
  • Sahib Zada Department of Microbiology, Faculty of Biological Sciences, Quaid-I-Azam University, Islamabad, Pakistan
  • Wasim Sajjad Department of Microbiology, Faculty of Biological Sciences, Quaid-I-Azam University, Islamabad, Pakistan
  • Tanweer Kumar State Key Laboratory of Grassland Agro-ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, PR China
Keywords: genomics, metabolomics, proteomics, proteogenomics, transcriptomics

Abstract

The term proteogenomics is basically the integration of proteomics with genomics and transcriptomics. Today, proteogenomics is developing on the way to combined understanding about overall cellular functions. At present globally, structure of genes, expression of genes (in the form of mRNA synthesis), synthesis of proteins (translation of mRNA) and post-translational modification (structural modification of proteins) have turn out to be technically practicable and act as a novel viewpoint to molecular procedures. Current research has proved the importance of proteogenomics technology in cancer for studying molecular signature of tumors particularly in human beings, and its treatment and prevention. Proteogenomics is not restricted to oncology but it also plays a vital role in other areas of life sciences and biomedicines and anticipation can make up these areas. Here in this minireview, we will discuss the latest progress made in recent years, challenges and viewpoints about proteogenomics technology.

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Published
2017-04-14
Section
Articles