@article{Andre Giovanni_Hendrawan_Mahdi_2022, title={Effect Ulomoides dermestoides extract to TNF-α expression and kidney histopathology in diabetic rat model}, volume={6}, url={https://journal.ipb.ac.id/index.php/arshivetlett/article/view/39983}, DOI={10.29244/avl.6.2.33-34}, abstractNote={<p>Type 1 diabetes mellitus is a degenerative disease that often occurs, that is caused by impaired insulin production and damage to the cell β pancreas. This disease is characterized by increased levels of glucose in the blood, which interferes with insulin production in the body. <em>Rattus norvegicus</em> was used as an animal model of diabetes mellitus with streptozotocin 20 mg/kg and five experimental groups with three therapeutic doses of 2.3 mg/kg, 4.6 mg/kg, and 9.2 mg/kg. The total flavonoid equivalent contained in <em>Ulomoides dermetoides</em> was 1.48 g/mL. Immunohistochemistry results showed therapeutic doses of 2.3 mg/kg and 4.6 mg/kg can reduce TNF-α expression in kidney tissue, but a dose of 9.2 mg/kg had no effect when compared to the positive control. Necrosis and protein deposits were seen in the renal tubules in the four treatment groups compared with the negative control. A dose of 2.3 mg/kg was the best treatment with high TNF-α expression and can repair kidney tissues.</p&gt;}, number={2}, journal={ARSHI Veterinary Letters}, author={Andre Giovanni and HendrawanViski Fitri and Mahdi, Chanif}, year={2022}, month={Aug.}, pages={33-34} }