Nutritional Status, Physical Activity, Oxidative Stress, and Cognitive Function in Pre Elderly and Elderly

  • Nunung Cipta Dainy Faculty of Medicine and Health, University of Muhammadiyah Jakarta, Jakarta 15419
  • Clara Meliyanti Kusharto 2Department of Community Nutrition, Faculty of Human Ecology, Bogor Agricultural University, Bogor 16680
  • Siti Madanijah 2Department of Community Nutrition, Faculty of Human Ecology, Bogor Agricultural University, Bogor 16680
  • Martina Wiwie Setiawan Nasrun Department of Psychiatry, Faculty of Medicine, University of Indonesia, Jakarta 10430
  • Yuda Turana Department of Neurology, School of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta 12930
Keywords: cognitive function, elderly, oxidized low-density lipoprotein, pre-elderly


This study aimed to analyse the relation of nutritional status, physical activity or oxidative stress with cognitive function of pre-elderly and elderly. A comparative cross-sectional study was conducted on 40 pre-elderly and 35 elderly subjects who were admitted to the Integrated Development Post Program (Posbindu) between September 2014 and January 2015. Anthropometric measurements (weight and height), physical activity, and biochemical data (oxidized low-density lipoprotein[Ox-LDL] and serum malondialdehyd [MDA]) were obtained. Nutritional status was assessed through body mass index (BMI), while the cognitive function was measured by Rey Osterrieth Complex Figure (ROCF) and Digit Span Backward. The data were analysed using an independent t-test and Spearman’s test with a confidence level of 95%. The study showed that the prevalence of malnutrition among the pre-elderly and elderly were 60.0% and 80.0%, respectively. Concerning physical activity, those who belonged to inactive-sedentary activity based on physical activity level (PAL) ratio were 55.0% and 45.7%, respectively. There were no significant differences in Ox-LDL, MDA levels and cognitive function (p>0.05). Significant negative correlations existed between Ox-LDL and immediate visual memory function (r=-0.289; p<0.05), as well as between Ox-LDL and delayed visual memory function (r=-0.288; p<0.05). The conclusion that visual memory function was only correlated with Ox-LDL.