The Activity of Wungu Leaf (<i>Graptophyllum pictum</i> (L) Griff) Extract in Reducing Blood Glucose Level of Hyperglycemic Mice

  • Hayatul Rahmi Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University
  • I Made Artika Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University
  • Norman Razief Azwar Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University
  • Djarot Sasongko Hami Seno Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University
  • Waras Nurcholis Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University
Keywords: Graptophyllum pictum (L.) Griff, partition extraction, ethyl acetate

Abstract

Wungu leaf (Graptophyllum pictum (L.) Griff) is a plant thought to have potential use in alleviating symptoms of diabetes mellitus. The purpose of the present study was to evaluate the activity of wungu leaf extracts in decreasing blood glucose level of alloxan (200 mg/kg BW)-induced hyperglycemic mice. Extracts of wungu leaf were obtained by macerating with ethanol and then partitioning the extract with diethyl ether, ethyl acetate, and butanol. Each extract obtained was used to treat hyperglycemic mice for 28 days. The results showed that wungu leaf extracts have the ability to decrease the blood glucose level of hyperglycemic mice (dose 50 mg/kg BW). The ethyl acetate extract showed the highest activity, bringing about a decrease of blood glucose of 37.6 %. The wungu leaf extract has the potential to be developed as a source of anti-diabetic agents.

References

Dalimartha, S. 1999. Atlas Tumbuhan Obat Indonesia. Jilid 1. Jakarta: Trubus Agriwidya.

Fahri C, Sutarno, Listyawati S. 2005. Kadar Glukosa dan Kolesterol Total Darah Tikus Putih (Rattus norvegicus L.) Hiperglikemik setelah Pemberian Ekstrak Metanol Akar Meniran (Phyllanthus niruri L.). Biofarmasi 3 : 1-6, Pebruari, ISSN: 1693-2242.

Nurcholis W, Andrianto D, Falah S, Katayama T. 2011. α-Glucosidase Inhibitor and cytotoxic activities and phytochemical sceening of Graptophyllum pictum (L.) griff. The 3rd International Symposium of Indonesian Wood Reseach Society, Yogyakarta- Indonesia, November 3rd to 4th, 2011.

Olagbende-Dada SO, Coker HAB, Ukpo GE, Adesina SA. 2009. Oxytocic and antiimplantation activities of the leaf extracts of Graptophyllum pictum (Linn.) Griff. (Acanthaceae). Afr. J. Biotechnol 8: 5979- 5984.

Olagbende-Dada SO, Ogbonia SO, Coker HAB, Ukpo GE. 2011. Blood glucose lowering effect of aqueous extract of Graptophyllum pictum (Linn.) Griff. On alloxan-induced diabetic rats and its acute toxicity in mice. Afr. J. Biotechnol 10: 1039-1043.

Rauter AP, Martin A, Lopes R, Ferreira J, Serralheiro LM, Araujo ME, Borges C, Justino J, Silva FV. 2009. Bioactivity studies and chemical profile of the antidiabetic plant genista terena. Journal of Enthopharmacology 122: 384-393.

Studiawan H and Santosa MH. 2005. Uji Aktivitas Penurunan Kadar Glukosa Darah Ekstrak Daun Eugenia polyantha pada Mencit yang Diinduksi Aloksan. Media Kedokteran Hewan 21: 62-65.

Suhargo L. 2005. Efek estrogenik ekstrak daun handeuleum (Graptophyllum pictum (L.) Griff) pada histologi uterus mencit betina ovariektomi. Berk. Penel. Hayati 10: 107-110.

Sunarsih ES, Djatmika, Utomo RS. 2007. Pengaruh pemberian infusa umbi gadung (Dioscorea hispida Densst) terhadap penurunan kadar glukosa darah tikus putih jantan diabetes yang diinduksi aloksan. Majalah Farmasi Indonesia 18: 29-33.

Widyowati R. 2011. Alkaline phosphatase activity of Graptophyllum pictum and Sphilanthes acmella fractions against MC3T3-E1 cells as marker of osteoblast differentiation cells. Int J Pharm Pharm Sci 3: 34-37.

Zuhra CF, Lenny S. 2005. Isolasi dan uji bioaktivitas kandungan utama pudding merah (Graptophyllum pictum (L.) Griff) dengan metode uji brine shrimp. Jurnal Komunikasi Penelitian 17: 56-59.

Published
2014-08-06
Section
Articles